MCCS: a novel recognition pattern-based method for fast track discovery of anti-SARS-CoV-2 drugs.

Author: ChenHui, ChenMaozi, FengZhiwei, LiangTianjian, NolinThomas D, SmithRandall B, XieXiang-Qun, XueYing, ZhouYuehan

Paper Details 
Original Abstract of the Article :
Given the scale and rapid spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or 2019-nCoV), there is an urgent need to identify therapeutics that are effective against COVID-19 before vaccines are available. Since the current rate...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665328/

データ提供:米国国立医学図書館(NLM)

Finding a Cure in the Sandstorm: A New Approach to Anti-SARS-CoV-2 Drug Discovery

The COVID-19 pandemic, like a raging desert sandstorm, swept across the globe, demanding a swift and effective response. The researchers in this study developed a novel method for identifying potential anti-SARS-CoV-2 drugs. They named this new approach the Molecular Complex Characterizing System (MCCS) and applied it to screen existing FDA-approved drugs for repurposing and combination therapies.

MCCS: A New Compass in the Desert of Drug Discovery

The MCCS approach is based on identifying key residues in the target protein and evaluating the binding affinity of potential drug candidates. The study found that several existing drugs, such as anti-HIV drugs, anti-flu drugs, and anti-HCV drugs, showed promising binding affinities to the 3CLPro protein of SARS-CoV-2. The researchers also identified potential drug combinations, such as remdesivir + chloroquine, which are currently undergoing clinical trials.

A Beacon of Hope in the Storm: New Tools for Fighting COVID-19

The MCCS approach is a significant step forward in the fight against COVID-19. By enabling the rapid identification and evaluation of potential drug candidates, this approach could accelerate the development of effective treatments. Just as a desert traveler relies on a compass to navigate, so do we rely on scientific advancements like the MCCS to guide us through the challenges of disease.

Dr.Camel's Conclusion

The COVID-19 pandemic was like a relentless desert storm, threatening to engulf the world. MCCS, like a sturdy camel, helps us navigate the challenges of drug discovery. This new approach has shown great promise in identifying potential anti-SARS-CoV-2 drugs, offering hope for a future where we can effectively combat this devastating disease.

Date :
  1. Date Completed 2021-04-14
  2. Date Revised 2021-04-14
Further Info :

Pubmed ID

33078827

DOI: Digital Object Identifier

PMC7665328

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English

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