Paper Details

  1. Home
  2. Paper Details

Starting stiripentol in adults with Dravet syndrome? Watch for ammonia and carnitine.

Author: AndradeDanielle M, MarquesPaula, SadowayTara, SelvarajahArunan, TabarestaniSepideh, Zulfiqar AliQuratulain

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Stiripentol (STP) is a treatment for Dravet syndrome (DS), a rare epileptic encephalopathy. While STP is beneficial in children, its use in adults can lead to encephalopathy. This study investigated the cause and treatment of encephalopathic manifestations associated with STP in adults.
Paper Details　
Original Abstract of the Article :
Dravet syndrome (DS) is a rare cause of severe and pharmacoresistant epileptic encephalopathy. Stiripentol (STP) has a significant therapeutic benefit in the pediatric DS population. However, STP effects on adult patients have not been well studied. In our adult STP-naive DS patient population, STP ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/epi.16684

データ提供：米国国立医学図書館（NLM）

Dravet Syndrome: Navigating the Desert of Epilepsy

Dravet syndrome, a rare and challenging form of epilepsy, can feel like navigating a vast and unforgiving desert of seizures and cognitive impairments. This research examines the use of stiripentol in adults with Dravet syndrome, a medication that has shown promise in managing seizures in children with this condition. The study investigated the effects of stiripentol on adults with Dravet syndrome, focusing on potential complications and treatment strategies.

Stiripentol: A Potential Oasis in the Desert of Epilepsy

The study highlights the potential benefits and challenges of using stiripentol in adults with Dravet syndrome. The researchers discovered that stiripentol can be effective in reducing seizures, but it can also lead to complications like encephalopathy, requiring careful monitoring and management. This research provides valuable insights into the potential of stiripentol for managing Dravet syndrome in adults.

Navigating the Desert of Epilepsy Treatment

This research emphasizes the importance of personalized treatment approaches for epilepsy, especially in the context of rare and complex disorders like Dravet syndrome. It underscores the need for close collaboration between patients and healthcare professionals to ensure the most effective management of seizures and minimize potential complications. By working together, individuals can find a more manageable path through the desert of epilepsy treatment.

Dr.Camel's Conclusion

The desert of Dravet syndrome can be a challenging landscape, but stiripentol offers a glimmer of hope, like an oasis in the sand. This research highlights the potential of this medication for reducing seizures in adults with Dravet syndrome, while also acknowledging the need for careful monitoring and management. By working closely with healthcare professionals, individuals can navigate the desert of epilepsy treatment more effectively and find a more comfortable journey through the desert of discomfort.

Date :
  1. Date Completed 2021-02-03
  2. Date Revised 2021-02-03
Further Info :

Pubmed ID

33084037

DOI: Digital Object Identifier

10.1111/epi.16684

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.