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9-cis Retinoic acid and 1.25-dihydroxyvitamin D<sub>3</sub> drive differentiation into IgA<sup>+</sup> secreting plasmablasts in human naïve B cells.
Author: GrünJoachim, HeineGuido, RadbruchAndreas, ScholzJosephine, TreptowSandra, WormMargitta
Original Abstract of the Article :
Calcitriol and 9-cis retinoic acid (9cRA) play a fundamental role in shaping the adaptive immune response by altering the Ig profile and the differentiation of B cells, controlled by their corresponding nuclear receptors, VDR and RAR. Herein, after the establishment of a plasmablast differentiation ...See full text at original site
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引用元：
https://doi.org/10.1002/eji.202048557
データ提供：米国国立医学図書館（NLM）
The Immune System's Orchestra: Calcitriol and 9-cis Retinoic Acid in IgA Production
Our immune system is a complex orchestra, with various players working in harmony to protect us from disease. This study investigates the roles of calcitriol and 9-cis retinoic acid (9cRA), two key players in this orchestra, in the production of IgA antibodies. The researchers explored how these molecules influence the differentiation of human naïve B cells into IgA-secreting plasmablasts. Their findings suggest that both calcitriol and 9cRA play important roles in promoting IgA production, acting in a synergistic manner.
Calcitriol and 9cRA: A Duo for IgA Production
The study highlights the complex interplay of various factors in shaping our immune responses. Calcitriol and 9cRA, acting in concert, play a crucial role in driving the differentiation of B cells into IgA-producing cells. This is a significant finding, as IgA is a vital antibody involved in mucosal immunity, protecting us from pathogens entering through our digestive and respiratory systems.
Strengthening Our Immune Defenses: Calcitriol and 9cRA
Imagine a camel navigating the desert, protected by a layer of strong and resilient skin. Just as the camel's skin shields it from the harsh environment, IgA antibodies act as our first line of defense against invading pathogens. Calcitriol and 9cRA, acting like a desert oasis, provide the necessary resources for our immune system to produce these crucial antibodies, strengthening our defenses against disease.
Dr.Camel's Conclusion
This study delves into the intricacies of our immune system, revealing the complex symphony of molecules and cells that work together to protect us. Calcitriol and 9cRA, like two important instruments in this orchestra, play critical roles in promoting IgA production, safeguarding our health and well-being. It's a reminder that by understanding the intricate mechanisms of our immune system, we can work towards strengthening our defenses and navigating the challenges of a complex world.
Date :
- Date Completed 2021-04-22
- Date Revised 2021-12-04
Further Info :
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