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Effects of chronic administration of codeine and promethazine on breathlessness and exercise tolerance in patients with chronic airflow obstruction.

Author: HedemarkL L, KronenbergR S, NiewoehnerD E, RiceK L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Chronic treatment with codeine or promethazine was not found to be more effective than placebo in treating 11 patients with chronic airflow obstruction. Four patients had to withdraw from the study due to worsening symptoms.
Paper Details　
Original Abstract of the Article :
It has been reported that short-term treatment with relatively high doses of opiates or promethazine causes improvements in dyspnoea and exercise tolerance in patients with chronic airflow obstruction (CAO). This study was designed to determine whether initial benefits were sustained during chronic ...See full text at original site
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引用元：
https://doi.org/10.1016/0007-0971(87)90163-x

データ提供：米国国立医学図書館（NLM）

Codeine and Promethazine: A Double-Edged Sword for Chronic Airflow Obstruction

Chronic airflow obstruction (CAO) is a serious respiratory condition that can significantly impact quality of life. This study investigates the effects of long-term codeine and promethazine treatment on breathlessness and exercise tolerance in patients with CAO. Imagine these drugs as two different paths through the desert, each offering potential benefits but also carrying risks.

Limited Benefits

The study found that chronic treatment with codeine or promethazine did not provide sustained benefits in terms of improving breathlessness or exercise tolerance. In fact, some patients experienced worsening of their CAO symptoms during treatment. It's like discovering that the desert oasis isn't as welcoming as you initially thought.

Weighing the Risks and Benefits

This research highlights the need for careful consideration when using codeine and promethazine for long-term treatment of CAO. The potential risks may outweigh the limited benefits, especially in patients with severe CAO.

Dr. Camel's Conclusion

The search for effective treatments for chronic airflow obstruction is an ongoing journey through the desert. This study reminds us that even medications that offer potential benefits can have unexpected side effects, and that careful evaluation is necessary before embarking on long-term treatment.

Date :
  1. Date Completed 1987-11-30
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

3311120

DOI: Digital Object Identifier

10.1016/0007-0971(87)90163-x

Related Literature

Article Analysis
・Effects of promethazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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