Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases.

Author: CrescimannoMarilena, FlandinaCarla, GiammancoMarco, LetoGaetano, SepportaMaria Vittoria

Paper Details 
Original Abstract of the Article :
Oleuropein (Ole) is the main bioactive phenolic compound present in olive leaves, fruits and olive oil. This molecule has been shown to exert beneficial effects on several human pathological conditions. In particular, recent preclinical and observational studies have provided evidence that Ole exhib...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.lfs.2020.118694

データ提供:米国国立医学図書館(NLM)

Oleuropein: A Potential Ally in the Fight Against Bone Diseases

Bone diseases, including metastatic bone diseases, are a significant health challenge. This research explores the potential therapeutic role of oleuropein, a bioactive compound found in olive leaves, fruits, and olive oil, in preventing and treating these diseases. The authors delve into the molecular mechanisms underlying oleuropein's effects on tumor cell growth and bone remodeling. They highlight the molecule's ability to interfere with key steps of malignant progression, including tumor cell proliferation, survival, angiogenesis, invasion, and metastasis. This multifaceted activity could potentially translate into a powerful tool for combating bone diseases.

Oleuropein's Promise for Bone Health

The research provides compelling evidence for oleuropein's potential to prevent and treat cancer-related bone diseases. Oleuropein's ability to modulate the expression and activity of various signaling molecules involved in tumor cell growth and bone remodeling suggests its therapeutic potential. The study emphasizes the role of oleuropein in thwarting the homing and growth of disseminating cancer cells in bones, ultimately contributing to the prevention and treatment of metastatic bone diseases.

Exploring a Natural Solution for Bone Health

This study highlights the importance of exploring natural compounds like oleuropein for their potential therapeutic applications. Oleuropein's ability to modulate cellular processes involved in bone health holds significant promise for developing new strategies to prevent and treat bone diseases. Further research is needed to translate these promising findings into clinical applications, potentially leading to new treatment options for patients.

Dr. Camel's Conclusion

In the vast and often unforgiving desert of bone diseases, oleuropein emerges as a potential oasis of hope. Its multifaceted activity, including its ability to suppress tumor cell growth and modulate bone remodeling, offers promising avenues for preventing and treating these diseases. Further research is needed to unravel the mysteries of this natural compound, potentially leading to new treatments for patients in need.

Date :
  1. Date Completed 2020-12-30
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

33130080

DOI: Digital Object Identifier

10.1016/j.lfs.2020.118694

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.