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Analysis of serum tranexamic acid in patients undergoing open heart surgery.

Author: GauthierJeannette, IvicaJosko, LamyAndré, PotterMurray, PowerPatricia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A validated LC-MS/MS method was developed for measuring serum tranexamic acid, which is used to prevent blood loss during open cardiac surgery. The method will be used to measure serum concentrations in patients from the DEPOSITION Pilot trial, which is designed to evaluate the effectiveness of topical tranexamic acid administration in reducing serum concentrations.
Paper Details　
Original Abstract of the Article :
Tranexamic acid is a drug used during open cardiac surgery to prevent blood loss. The blood levels of 10-100 µg/mL are reported to be in the therapeutic range and higher levels are linked to increased incidence of adverse effects. The aim of this study was to optimize and validate an LC-MS/MS method...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinbiochem.2020.10.010

データ提供：米国国立医学図書館（NLM）

Analysis of Serum Tranexamic Acid in Patients Undergoing Open Heart Surgery

Open heart surgery is a complex and delicate procedure that often involves significant blood loss. This research focuses on the use of tranexamic acid, a medication that helps control blood loss during surgery. The researchers investigated the levels of tranexamic acid in the blood of patients undergoing open heart surgery, aiming to optimize the dosage and administration of this medication to ensure its effectiveness while minimizing potential side effects.

Tranexamic Acid: A Crucial Ingredient in the Cardiac Operating Room

This research, like a skilled surgeon navigating the delicate landscape of open heart surgery, explores the use of tranexamic acid to control blood loss during these complex procedures. The researchers were particularly interested in understanding the optimal levels of tranexamic acid in the blood, seeking to balance effectiveness with safety. Their findings suggest that topical administration of tranexamic acid may lead to lower serum concentrations compared to traditional methods.

Balancing Blood Loss and Safety: A Delicate Dance

The study highlights the importance of optimizing drug administration to maximize efficacy while minimizing potential risks. Dr. Camel recognizes that open heart surgery is a high-risk procedure, and ensuring the safe and effective use of medications like tranexamic acid is critical. This research underscores the need for continuous refinement of medical practices to improve patient outcomes.

Dr. Camel's Conclusion

This research demonstrates the meticulous attention to detail required in the world of cardiac surgery. Dr. Camel, with his deep respect for the precision and expertise of medical professionals, believes that this study will contribute to the development of safer and more effective treatment strategies for patients undergoing open heart surgery.
Date :
  1. Date Completed 2021-05-24
  2. Date Revised 2021-05-24
Further Info :

Pubmed ID

33188769

DOI: Digital Object Identifier

10.1016/j.clinbiochem.2020.10.010

SNS
PICO Info
in preparation
Languages

English

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