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Progestogens or progestogen-releasing intrauterine systems for uterine fibroids (other than preoperative medical therapy).

Author: LumbiganonPisake, PattanittumPorjai, SangkomkamhangUssanee S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review assessed the effectiveness of progestogens or progestogen-releasing intrauterine systems (IUS) for treating premenopausal women with uterine fibroids. The evidence is very low quality and inconclusive due to limited studies and poor reporting of study methods. LNG-IUS may reduce abnormal uterine bleeding compared to combined oral contraceptive (COC) or norethisterone acetate, but there is insufficient evidence to determine if it reduces fibroid size. Oral progestogens may reduce abnormal uterine bleeding as effectively as goserelin acetate, but women reported fewer adverse events, such as hot flashes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Uterine fibroids can cause heavy menstrual bleeding. Medical treatments are considered to preserve fertility. It is unclear whether progestogens or progestogen-releasing intrauterine systems can reduce fibroid-related symptoms. This is the first update of a Cochrane Review published in 2...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094271/

データ提供：米国国立医学図書館（NLM）

Progestogens and Progestogen-Releasing IUDs: Treating Uterine Fibroids

Gynecology is a complex field, where doctors grapple with the intricate workings of the female reproductive system. This study explores the potential of progestogens and progestogen-releasing intrauterine systems (IUS) for treating uterine fibroids, which can cause heavy menstrual bleeding. The researchers conducted a systematic review to assess the effectiveness of these treatments in premenopausal women with uterine fibroids, aiming to provide evidence-based guidance for clinical practice.

Navigating the Treatment Landscape for Uterine Fibroids

The researchers found very low-quality evidence regarding the effectiveness of progestogens and progestogen-releasing IUDs in treating uterine fibroids. This is due to limitations in the available studies, including small sample sizes and poor reporting of study methods. Imagine a vast desert of research, with scattered oases of studies offering limited insights into the effectiveness of these treatments. The researchers urge for more robust research to clarify the role of these therapies in managing uterine fibroids.

Considerations for Women with Uterine Fibroids

The study emphasizes the need for more research to determine the optimal treatment approach for premenopausal women with uterine fibroids. While progestogens and progestogen-releasing IUDs may offer potential benefits, the current evidence is insufficient to provide definitive recommendations. This research underscores the importance of careful consideration and individualized decision-making in the management of uterine fibroids.

Dr.Camel's Conclusion

This research offers a glimpse into the complex world of uterine fibroids and their treatment. While the current evidence is limited, it highlights the need for further research to guide clinical practice. The researchers urge for a collaborative effort to navigate the vast desert of knowledge surrounding uterine fibroids, ultimately striving for better outcomes for women facing these challenging conditions.

Date :
  1. Date Completed 2020-12-21
  2. Date Revised 2023-07-01
Further Info :

Pubmed ID

33226133

DOI: Digital Object Identifier

PMC8094271

Related Literature

Article Analysis
・Effective treatment of uterine fibroids
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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