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An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen.
Author: HansenElsa, JacksonLindsey M, KinnearClare L, MorleyValerie J, OlsonSamantha N, PaiManjunath P, ReadAndrew F, ShowalterScott A, SimDerek G, UsherGrace A, WoodsRobert J
Original Abstract of the Article :
A key challenge in antibiotic stewardship is figuring out how to use antibiotics therapeutically without promoting the evolution of antibiotic resistance. Here, we demonstrate proof of concept for an adjunctive therapy that allows intravenous antibiotic treatment without driving the evolution and on...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707840/
データ提供:米国国立医学図書館(NLM)
Antibiotic Resistance: A Desert of Evolving Threats
In the relentless desert of antibiotic resistance, the battle against bacterial infections is constantly evolving. This study explores a novel approach to combating this challenge, like a desert explorer seeking a new and effective way to navigate the treacherous landscape. Researchers investigated the potential of using an adjunctive therapy, cholestyramine, a bile acid sequestrant, alongside daptomycin, an antibiotic, to prevent the emergence of antibiotic-resistant bacterial clones. They found that cholestyramine, by binding to daptomycin, could disable its systemic reach, allowing targeted treatment in the bloodstream while minimizing the selection pressure for antibiotic resistance in the gut. This approach could be a promising strategy for preventing the evolution and spread of antibiotic resistance.
A New Oasis in the Desert: Combating Antibiotic Resistance
This study presents a promising new approach to combating the challenge of antibiotic resistance. The researchers found that an adjunctive therapy, cholestyramine, could prevent the emergence of antibiotic-resistant clones by disabling daptomycin's reach to the gut. This could be a significant breakthrough in the fight against antibiotic resistance, potentially reducing the spread of these harmful bacteria.
Navigating the Desert of Antibiotic Resistance: A Collective Effort
The desert of antibiotic resistance is a challenging one to navigate, requiring a collective effort to find effective solutions. This study highlights the importance of developing innovative strategies to prevent the emergence of antibiotic resistance. Through continued research and development of new approaches, we can combat this threat and ensure the effectiveness of antibiotics for future generations.
Dr.Camel's Conclusion
This study offers a glimmer of hope in the desert of antibiotic resistance. The use of cholestyramine as an adjunctive therapy could potentially prevent the emergence of antibiotic-resistant clones, giving us a new weapon in the fight against these evolving threats. This research highlights the importance of exploring new and innovative strategies to combat antibiotic resistance, a challenge that requires a collective effort to overcome.
Date :
- Date Completed 2021-03-08
- Date Revised 2021-03-08
Further Info :
Related Literature
English
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