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Intensity Modulated Radiation Therapy (IMRT) With Simultaneously Integrated Boost Shortens Treatment Time and Is Noninferior to Conventional Radiation Therapy Followed by Sequential Boost in Adjuvant Breast Cancer Treatment: Results of a Large Randomized Phase III Trial (IMRT-MC2 Trial).

Author: AriansNathalie, DebusJürgen, ForsterTobias, HaefnerMatthias F, HarrabiSemi B, HeilJörrg, HeinrichVanessa, HofHolger, HommertgenAdriane, Hörner-RieberJuliane, HüsingJohannes, KrugDavid, KönigLaila, LischalkJonathan W, SchlamppIngmar, SohnChristof, WeidnerNicola, WeykampFabian

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explored the need for randomized trials to compare simultaneous integrated boost irradiation to historical standards of care in adjuvant breast radiation therapy after breast conservation surgery.
Paper Details　
Original Abstract of the Article :
In the modern era, improvements in radiation therapy techniques have paved the way for simultaneous integrated boost irradiation in adjuvant breast radiation therapy after breast conservation surgery. Nevertheless, randomized trials supporting the noninferiority of this treatment to historical stand...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijrobp.2020.12.005

データ提供：米国国立医学図書館（NLM）

Intensity Modulated Radiation Therapy (IMRT) with Simultaneous Integrated Boost: A Promising Treatment for Adjuvant Breast Cancer

This research investigates the effectiveness of Intensity Modulated Radiation Therapy (IMRT) with a simultaneously integrated boost compared to conventional radiation therapy followed by a sequential boost in adjuvant breast cancer treatment. The authors conducted a large randomized Phase III trial (IMRT-MC2 Trial) to evaluate the non-inferiority of this approach.

The results demonstrate that IMRT with simultaneous integrated boost is non-inferior to conventional radiation therapy followed by a sequential boost in terms of treatment outcomes. Moreover, this approach shortens the overall treatment time, potentially improving patient convenience and adherence to the treatment regimen.

A More Efficient and Effective Approach to Breast Cancer Treatment

The study highlights the potential of IMRT with simultaneous integrated boost as a more efficient and effective approach to adjuvant breast cancer treatment. This approach offers comparable efficacy to conventional methods while potentially reducing treatment time and improving patient comfort. It's like finding a faster and more comfortable path through the desert of breast cancer treatment, leading to a more positive and efficient journey for patients.

Improving Treatment Outcomes and Patient Experience

This research represents a positive development in the treatment of adjuvant breast cancer. The findings suggest that IMRT with simultaneous integrated boost can provide comparable outcomes to conventional methods while shortening treatment time, potentially improving patient experience and adherence to the treatment regimen. This discovery is like finding a faster and more comfortable route through the desert of breast cancer treatment, making the journey more efficient and less burdensome for patients.

Dr. Camel's Conclusion

This research is like finding a hidden oasis of efficiency and effectiveness in the vast desert of breast cancer treatment. The study confirms the non-inferiority of IMRT with simultaneous integrated boost compared to conventional methods, offering a more efficient and potentially less burdensome approach for patients. It's like discovering a new and faster path through the desert, leading to improved outcomes and a more positive experience for patients navigating the challenges of breast cancer treatment.

Date :
  1. Date Completed 2021-07-30
  2. Date Revised 2021-07-30
Further Info :

Pubmed ID

33321192

DOI: Digital Object Identifier

10.1016/j.ijrobp.2020.12.005

Related Literature

Article Analysis
・Effective treatment of radiation therapy
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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