Effective treatment of radiation therapy: A Synthesis of Findings from 37 Studies

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Original Abstract of the Article

Major Research Findings

Radiation therapy plays a crucial role in treating various types of cancer, including oral cancer, prostate cancer, breast cancer, Hodgkin's lymphoma, bone metastases, head and neck cancer, esophageal cancer, and brain tumors. These papers investigate different aspects of radiation therapy. For instance, in treating oral cancer, a study compared the effectiveness of twice-a-week radiation with five-times-a-week radiation, showing the latter to be more effective. 8 In treating prostate cancer, the effectiveness of different radiation therapy approaches was compared, but no definitive conclusions were drawn. 22 In breast cancer treatment, studies explored the connection between the number of radiation therapy fractions and effectiveness, suggesting that high-dose radiation delivered over a shorter period, known as "hypofractionated radiation therapy," could be effective compared to conventional methods. 19 Furthermore, comparisons were made regarding side effects resulting from different types of radiation therapy. 25

Treatment Summary

These papers highlight the ongoing research into various radiation therapy approaches. For example, oral cancer treatment involves different fractionation schedules like twice-a-week and five-times-a-week radiation. 8 Prostate cancer treatment explores various dose levels and fractionation methods. 22 Breast cancer treatment compares "hypofractionated radiation therapy" with conventional methods, where high-dose radiation is delivered over a shorter period. 19 Head and neck cancer treatment investigates the effectiveness of pre-operative radiation versus post-operative radiation. 7 Esophageal cancer treatment compares proton therapy with traditional radiation therapy. 35 Brain tumor treatment explores the use of "intraoperative radiation therapy," where radiation is delivered during surgery. 34

Benefits and Risks

Benefits Summary

These studies demonstrate that radiation therapy is an effective treatment option for various types of cancer. Notably, in oral and breast cancers, radiation therapy improves local tumor control rates. 8 19 29 Furthermore, the development of new radiation methods like hypofractionated radiation therapy holds promise for shorter treatment durations and fewer side effects. 19 25 33 Proton therapy potentially minimizes impact on healthy tissues compared to conventional radiation therapy, potentially reducing side effects. 35

Risks Summary

Radiation therapy carries the risk of various side effects, including skin inflammation, mouth sores, and digestive issues. These papers indicate that side effect severity can vary depending on the type and fractionation method of radiation therapy. 8 25 29 28 Minimizing side effect risk necessitates a well-defined treatment plan, early detection of potential side effects, and appropriate management. 20

Comparison of Studies

Commonalities

These papers explore various aspects of radiation therapy. They share the common goal of enhancing treatment effectiveness while minimizing side effects. Another shared characteristic is the vigorous development of new radiation therapy technologies and approaches.

Differences

These papers differ in terms of the type of cancer being studied, treatment methods employed, and evaluation criteria. Consequently, results obtained in each paper may not be identical. For instance, in oral cancer treatment, the effectiveness of twice-a-week and five-times-a-week radiation was compared, but similar comparative research wasn't conducted for other cancer types. 8 Additionally, while the effectiveness of various radiation therapies for prostate cancer is compared, the evaluation criteria used in each paper vary. 22

Consistency and Contradictions in Results

These papers reveal consistent findings regarding the effectiveness and side effects of radiation therapy. However, some papers present conflicting results. For example, the effectiveness of hypofractionated radiation therapy in breast cancer treatment shows variation across studies, with some indicating its effectiveness compared to conventional methods, while others don't show a significant difference. 19 24 These discrepancies could arise due to variations in the patient population, treatment methods, or evaluation criteria.

Real-World Applications and Cautions

Radiation therapy, while an effective treatment for various cancers, also involves side effect risks. Before undergoing radiation therapy, it's essential to have a detailed discussion with your doctor to select the treatment method most suitable for your situation. During treatment, be vigilant for side effects and consult your doctor immediately if any arise.

Current Research Limitations

Despite these studies exploring various aspects of radiation therapy, significant challenges remain. For instance, the long-term impacts of radiation therapy and variations in treatment effectiveness based on individual differences are yet to be fully understood. While the development of new radiation therapy technologies and approaches is advancing, further research is needed to thoroughly confirm their effectiveness and safety.

Future Research Directions

Future research on radiation therapy should focus on areas such as: ・ Comprehensive studies on the long-term effects of radiation therapy ・ Development of personalized treatment plans tailored to individual patient characteristics and conditions ・ Validation of the effectiveness and safety of new radiation therapy technologies and approaches ・ Research into new treatment methods for mitigating side effects of radiation therapy.

Conclusion

Radiation therapy is a valuable treatment option for numerous cancer types. However, it carries side effect risks, necessitating careful treatment planning and vigilance for side effects. Further research holds the promise of enhancing the safety and effectiveness of radiation therapy. It is crucial to discuss with your doctor and make informed decisions regarding your cancer treatment.

Treatment List

・ Twice-a-week radiation ・ Five-times-a-week radiation ・ Hypofractionated radiation therapy ・ Proton therapy ・ Intraoperative radiation therapy ・ Pre-operative radiation ・ Post-operative radiation

Keywords
Benefit Keywords
Improved tumor control
Reduced normal tissue damage
1
Lung cancer palliation
2
Pancreatic cancer treatment
3
Locoregional control improvement
4
Minor complications
No difference in effectiveness
5
Lung cancer treatment
6
Locoregional control
Survival
7
Palliative radiation therapy
8
Equivalent survival rates to mastectomy
Good cosmetic results
Improved local tumor control
9
Cancer control
10
Improved survival
Reduced late morbidity
12
Improved survival
Reduced chemotherapy dose
13
Reduced workload
14
Pain relief
15
Restenosis treatment
16
Improved locoregional control
Improved tumor control
17
Hodgkin's disease treatment
18
Improved access to radiation therapy
19
Improve radiation therapy
20
Improved survival rate
21
Biochemical control
22
Breast cancer treatment
23
Efficacy
Outcome
24
Prostate cancer treatment
25
Improved survival
Local control of disease
26
Reduced side effects
Reduced toxicity
27
Improved quality of life
28
Reduced dermatitis
Reduced desquamation
29
Improved local control
Improved survival
Reduced late toxicities
30
Head and neck cancer treatment
31
Improved disease control
Prostate cancer treatment
32
Improved breast cancer treatment
33
GBM treatment
34
Esophageal cancer treatment
35
High CR rate
Minimal toxicities
36
Reduced neuropsychological sequelae
37
Risk Keywords
Radiation therapy complications
Surgical complications
7
Tumor regression less effective
8
Increased early toxicity
12
Long-term toxicity
13
Increased late effects
Poorer cosmetic outcome
14
No difference between 6 Gy and 8 Gy
15
Accelerated vascular disease
Aneurysm formation
Perforation
16
Late toxicity
25
Infection
Radiation necrosis
34
Literature analysis of 37 papers
Positive Content
36
Neutral Content
1
Negative Content
0
Article Type
25
7
8
9
37
1.

Optimized radiotherapy for head and neck cancer.

Author: RussellN S, BartelinkH

Improved tumor control
Reduced normal tissue damage

Optimizing radiation therapy for head and neck tumors requires combining radiation biology and physics to maximize tumor control while minimizing normal tissue damage. Techniques to predict treatment response based on tumor sensitivity and growth characteristics are gaining importance. Three-dimensional treatment planning allows for dose escalation and reduced normal tissue damage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

2.

Palliative radiotherapy.

Author: AwanA M, WeichselbaumR R

Lung cancer palliation

Radiation therapy effectively alleviates symptoms associated with non-small cell lung cancer, including pain, shortness of breath, and neurologic complications. It is a widely applicable treatment that offers prompt relief with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Future prospects of radiotherapy in pancreatic cancer.

Author: FietkauR, SauerR

Pancreatic cancer treatment

Radiation therapy is not effective for inoperable pancreatic cancer alone, but combining it with chemotherapy or interventional techniques can improve outcomes. Adjuvant radio-chemotherapy may also improve survival after surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Innovative techniques in radiation oncology. Clinical research programs to improve local and regional control in cancer.

Author: BradyL W, MarkoeA M, MicailyB, FisherS A, LammF R

Locoregional control improvement

This review highlights the importance of preventing cancer from spreading locally (locoregional control) in many types of cancers, including head and neck, gynecologic, and genitourinary cancers. The review discusses various research efforts to improve locoregional control, including different radiation therapy techniques (brachytherapy, intraoperative radiation, hyperthermia, particle radiation), and combinations of radiation with chemotherapy or targeted therapies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The use of a specific hypofractionated radiation therapy regimen versus classical fractionation in the treatment of breast cancer: a randomized study of 230 patients.

Author: BailletF, HoussetM, MaylinC, BoisserieG, BettaharR, DelanianS, HabibF

Minor complications
No difference in effectiveness

This study compared the effectiveness of two radiation therapy regimens for breast cancer: a standard regimen (IC) and a shorter, more intense regimen (IHF). After following 230 patients for 4-7 years, there was no significant difference in the rates of local recurrence or complications between the two groups. While the study is ongoing, these preliminary findings suggest that both regimens are equally effective in treating breast cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Radical radiation therapy for lung cancer.

Author: SeagrenS L

Lung cancer treatment

Despite early trials suggesting a wait-and-see approach for non-resectable lung cancer, advancements in staging, treatment planning, and understanding of prognostic factors have led to a 20-30% 2-year survival rate with radical radiotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group.

Author: KramerS, GelberR D, SnowJ B, MarcialV A, LowryL D, DavisL W, ChandlerR

Locoregional control
Survival
Radiation therapy complications
Surgical complications

This study compared the effectiveness of giving radiation therapy before or after surgery in 320 patients with advanced cancers of the larynx, hypopharynx, oral cavity, or oropharynx. For cancers of the larynx and hypopharynx, post-operative radiation therapy was significantly more effective in controlling the cancer locally, with a 65% success rate compared to 48% for pre-operative radiation. Post-operative radiation also showed a trend towards better survival. While the study also compared pre-operative, post-operative, and definitive radiation therapy for cancers of the oral cavity and oropharynx, the small number of patients made it difficult to draw definitive conclusions. The study suggests that post-operative radiation therapy may be a better option for treating advanced cancers of the larynx and hypopharynx, but further research is needed to determine the best approach for cancers of the oral cavity and oropharynx.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

A radiotherapeutic clinical trial of twice per week vs. five times per week in oral cancer.

Author: HandaK, EdoliyaT N, PandeyR P, AgarwalY C, SinhaN

Palliative radiation therapy
Tumor regression less effective

A study of 250 patients with oral cancer compared the effectiveness of daily radiation therapy to twice-weekly radiation therapy. Daily radiation therapy resulted in significantly better tumor regression, acute and late side effects, and tumor control at one year, particularly for patients receiving radical treatment. While daily radiation therapy was still preferable for palliative treatment, the difference in outcomes was less pronounced. The study concludes that twice-weekly radiation therapy may be a suitable alternative only for palliative treatment of advanced oral cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Primary radiation therapy for early breast cancer.

Author: HarrisJ R, HellmanS

Equivalent survival rates to mastectomy
Good cosmetic results
Improved local tumor control

A review of studies using primary radiation therapy for early breast cancer found that it achieved high levels of local tumor control with good cosmetic results. A randomized clinical trial suggested that primary radiation therapy is as effective as mastectomy in terms of survival rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparison of preoperative and postoperative radiation therapy for patients with carcinoma of the head and neck. Interim report.

Author: SnowJ B, GelberR D, KramerS, DavisL W, MarcialV A, LowryL D

Cancer control

This interim report on 320 patients with squamous cell carcinoma of the head and neck found that surgery followed by postoperative radiation therapy was significantly better for local control in patients with supraglottic larynx cancer. There were no statistically significant treatment differences in local control or survival for other sites, including oral cavity, oropharynx, and hypopharynx.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Randomized preoperative and postoperative radiation therapy for patients with carcinoma of the head and neck: preliminary report.

Author: SnowJ B, GelberR D, KramerS, DavisL W, MarcialV A, LowryL D

This interim report on 243 patients with squamous cell carcinoma of the head and neck found that there were no statistically significant differences in local control or survival between the three treatment groups at this time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Randomised multicentre trials of CHART vs conventional radiotherapy in head and neck and non-small-cell lung cancer: an interim report. CHART Steering Committee.

Author: SaundersM I, DischeS, BarrettA, ParmarM K, HarveyA, GibsonD

Improved survival
Reduced late morbidity
Increased early toxicity

CHART, a type of accelerated radiotherapy, significantly improved survival in patients with non-small-cell lung cancer compared to conventional radiotherapy. However, it showed only a small, non-significant improvement in the disease-free interval for patients with head and neck cancer. CHART resulted in earlier and more troublesome mucosal reactions, but these quickly subsided, and no difference in long-term morbidity has been observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Hodgkin's disease--the role of radiation therapy in advanced disease.

Author: HoppeR T

Improved survival
Reduced chemotherapy dose
Long-term toxicity

This study reviewed the various roles of radiation therapy (XRT) in the management of advanced Hodgkin's disease (HD). It discussed the use of XRT as an adjuvant after chemotherapy, to convert partial responders to complete responders, as an integrated component of combined modality therapy, as a salvage treatment after chemotherapy failure, and in high-dose therapy programs with autologous stem cell rescue.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Late cosmetic results of short fractionation for breast conservation.

Author: OlivottoI A, WeirL M, Kim-SingC, BajdikC D, TrevisanC H, DollC M, LamW Y, BascoV E, JacksonS M

Reduced workload
Increased late effects
Poorer cosmetic outcome

The study discusses the different approaches to radiation therapy after breast-conserving surgery for breast cancer, exploring the advantages and concerns related to shorter radiation schedules.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

A randomized trial of three single-dose radiation therapy regimens in the treatment of metastatic bone pain.

Author: JeremicB, ShibamotoY, AcimovicL, MilicicB, MilisavljevicS, NikolicN, AleksandrovicJ, IgrutinovicI

Pain relief
No difference between 6 Gy and 8 Gy

Single-fraction radiation therapy for painful bone metastasis was most effective with 8 Gy, with significantly higher response rates and faster pain relief compared to 4 Gy. While 6 Gy also showed significant improvement, further research is needed to determine the optimal single dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Two-year follow-up after catheter-based radiotherapy to inhibit coronary restenosis.

Author: TeirsteinP S, MassulloV, JaniS, RussoR J, CloutierD A, SchatzR A, GuarneriE M, SteutermanS, SirkinK, NormanS, TripuraneniP

Restenosis treatment
Accelerated vascular disease
Aneurysm formation
Perforation

This study discusses the potential long-term consequences of using radiation therapy to treat restenosis, highlighting the need for further research on the durability of the treatment's benefits and the potential for late complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers.

Author: DobrowskyW, NaudéJ

Improved locoregional control
Improved tumor control

Radiation therapy is a common treatment for advanced head and neck cancers that cannot be surgically removed. However, the success rate of controlling the cancer in the local area is low, leading to the development of new approaches, including different radiation schedules and combination with chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

ABVD plus subtotal nodal versus involved-field radiotherapy in early-stage Hodgkin's disease: long-term results.

Author: BonadonnaGianni, BonfanteValeria, VivianiSimonetta, Di RussoAnna, VillaniFabrizio, ValagussaPinuccia

Hodgkin's disease treatment

While radiation therapy (RT) alone can cure a significant proportion of patients with early-stage Hodgkin's disease, combined-modality approaches have improved outcomes. Further evaluation is needed to determine the optimal extent of RT fields when combined with chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Fraction size in radiation treatment for breast conservation in early breast cancer.

Author: JamesMelissa L, LehmanMargot, HiderPhil N, JefferyMark, FrancisDaniel P, HickeyBrigid E

Improved access to radiation therapy

This study explores the potential of shortening radiation therapy for women with early breast cancer who are having breast conservation surgery. The study acknowledges that shorter treatment could improve patient experience and potentially increase access to care, but emphasizes the need to ensure that shorter treatment is equally effective and safe as traditional radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Accurate accumulation of dose for improved understanding of radiation effects in normal tissue.

Author: JaffrayDavid A, LindsayPatricia E, BrockKristy K, DeasyJoseph O, ToméW A

Improve radiation therapy

This article discusses the need for robust methods to track the accumulation of radiation dose within various tissues in the body to improve radiation outcomes modeling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Postoperative chemo-radiotherapy with temodal in patients with glioblastoma multiforme--survival rates and prognostic factors.

Author: YanevaMarianna P, SemerdjievaMaria L, RadevLyudmil R, VlaikovaMaria I

Improved survival rate

This study compared the survival rate of patients with glioblastoma multiforme (GM) who received radiation therapy only to those who received simultaneous treatment with Temodal and radiation therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Comparative evaluation of radiation treatments for clinically localized prostate cancer: an updated systematic review.

Author: BannuruRaveendhara R, DvorakTomas, ObadanNdidiamaka, YuWinifred W, PatelKamal, ChungMei, IpStanley

Biochemical control

A higher EBRT dose was associated with increased rates of long-term biochemical control compared with lower EBRT dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Simultaneous integrated boost for adjuvant treatment of breast cancer--intensity modulated vs. conventional radiotherapy: the IMRT-MC2 trial.

Author: AskoxylakisVasileios, JensenAlexandra D, HäfnerMatthias F, FetznerLeonie, SterzingFlorian, HeilJoerg, SohnChristof, HüsingJohannes, TiefenbacherUta, WenzFrederik, DebusJürgen, HofHolger

Breast cancer treatment

Radiation therapy is a crucial part of breast cancer treatment, improving outcomes and survival. However, it can cause side effects like tissue scarring and vascular problems. Intensity modulated radiotherapy (IMRT) allows for faster treatment by combining a higher dose to the tumor area, but it's unclear whether this approach can be used without affecting treatment outcomes or causing cosmetic issues.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Similar Outcomes of Standard Radiotherapy and Hypofractionated Radiotherapy Following Breast-Conserving Surgery.

Author: HouHai-Ling, SongYong-Chun, LiRui-Ying, ZhuLi, ZhaoLu-Jun, YuanZhi-Yong, YouJin-Qiang, ChenZhong-Jie, WangPing

Efficacy
Outcome

Adjuvant radiation therapy is a standard treatment for breast cancer patients who have undergone breast-conserving surgery. This study compares the efficacy and outcomes of standard radiotherapy to hypofractionated radiotherapy in these patients.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From 2 Prospective Cohorts.

Author: WortelRuud C, IncrocciLuca, PosFloris J, van der HeideUulke A, LebesqueJoos V, AluwiniShafak, WitteMarnix G, HeemsbergenWilma D

Prostate cancer treatment
Late toxicity

This study compares late side effects of image-guided intensity modulated radiation therapy (IG-IMRT) to three-dimensional conformal radiation therapy (3D-CRT) in men treated for prostate cancer.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Intraoperative radiation therapy (IORT) in head and neck cancer: A systematic review.

Author: KyrgiasGeorge, HajiioannouJiannis, ToliaMaria, KoulouliasVassilios, LachanasVasileios, SkoulakisCharalambos, SkarlatosIoannis, RapidisAlexandros, BizakisIoannis

Improved survival
Local control of disease

This review summarizes recent research on the use of intraoperative radiation therapy (IORT) as an adjuvant treatment for head and neck cancer. IORT offers a potential benefit by delivering a high dose of radiation directly to the tumor bed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial.

Author: MeyerhofEva, SpraveTanja, WelteStefan Ezechiel, NicolayNils H, FörsterRobert, BostelTilman, BrucknerThomas, SchlamppIngmar, DebusJürgen, RiefHarald

Reduced side effects
Reduced toxicity

Radiation therapy (RT) is an important treatment for cancer that has spread to the bones (bone metastases). However, radiation can cause side effects that affect quality of life. This study aims to reduce these side effects by using intensity-modulated radiation therapy (IMRT), which is a more precise way to deliver radiation, sparing healthy tissues.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial) : First results of a randomized controlled trial.

Author: SpraveTanja, VermaVivek, FörsterRobert, SchlamppIngmar, BrucknerThomas, BostelTilman, WelteStefan Ezechiel, Tonndorf-MartiniEric, El ShafieRami, NicolayNils Henrik, DebusJürgen, RiefHarald

Improved quality of life

This study compared the toxicity profiles of intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy (3DCRT) in the palliative care of vertebral metastases, considering the potential impact on quality of life in patients with advanced disease.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Side Effects Associated with the Use of Intensity-Modulated Radiation Therapy in Breast Cancer Patients Undergoing Adjuvant Radiation Therapy: A Systematic Review and Meta-Analysis.

Author: JensenKatherine E, SorilLesley J J, StelfoxHenry T, ClementFiona M, LinYongtao, MarshallDeborah A

Reduced dermatitis
Reduced desquamation

Intensity-modulated radiation therapy (IMRT) is a viable treatment option for women undergoing external beam RT after breast-conserving surgery, potentially protecting against dermatitis and moist desquamation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

The effectiveness of intensity-modulated radiation therapy versus 2D-RT for the treatment of nasopharyngeal carcinoma: A systematic review and meta-analysis.

Author: DuTaifeng, XiaoJiefeng, QiuZhaolong, WuKusheng

Improved local control
Improved survival
Reduced late toxicities

A meta-analysis of 10 studies involving 13,304 patients with nasopharyngeal carcinoma (NPC) revealed that intensity-modulated radiotherapy (IMRT) provided improved long-term overall survival, local control, and progression-free survival compared to 2D-RT. IMRT also resulted in a lower incidence of late toxicities.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Implementation of meta-analysis approach, comparing conventional radiotherapy, and proton beam therapy treating head and neck cancer.

Author: ShaikhFirdous, SodhiSonia Kaur, KaleLata M, TalibYusuf A, SaleemHuma Md

Head and neck cancer treatment

Radiation therapy is a common treatment for head and neck cancer. Proton therapy, a newer type of radiation, can target the cancer more precisely while reducing the amount of radiation exposure to healthy tissues.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

32.

Tumor Control Probability Modeling and Systematic Review of the Literature of Stereotactic Body Radiation Therapy for Prostate Cancer.

Author: RoyceTrevor J, MavroidisPanayiotis, WangKyle, FalchookAaron D, SheetsNathan C, FullerDonald B, CollinsSean P, El NaqaIssam, SongDaniel Y, DingGeorge X, NahumAlan E, JacksonAndrew, GrimmJimm, YorkeEllen, ChenRonald C

Improved disease control
Prostate cancer treatment

Ultrahypofractionation with stereotactic body radiation therapy allows for increased biological dose escalation and shortened treatment times for localized prostate cancer, potentially improving disease control.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Intensity Modulated Radiation Therapy (IMRT) With Simultaneously Integrated Boost Shortens Treatment Time and Is Noninferior to Conventional Radiation Therapy Followed by Sequential Boost in Adjuvant Breast Cancer Treatment: Results of a Large Randomized Phase III Trial (IMRT-MC2 Trial).

Author: Hörner-RieberJuliane, ForsterTobias, HommertgenAdriane, HaefnerMatthias F, AriansNathalie, KönigLaila, HarrabiSemi B, SchlamppIngmar, WeykampFabian, LischalkJonathan W, HeinrichVanessa, WeidnerNicola, HüsingJohannes, SohnChristof, HeilJörrg, HofHolger, KrugDavid, DebusJürgen

Improved breast cancer treatment

This study explored the need for randomized trials to compare simultaneous integrated boost irradiation to historical standards of care in adjuvant breast radiation therapy after breast conservation surgery.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Intraoperative radiotherapy for glioblastoma: A systematic review of techniques and outcomes.

Author: YlananAveline Marie D, PascualJuan Silvestre G, Cruz-LimElla Mae D, IgnacioKatrina Hannah D, CañalJohanna Patricia A, KhuKathleen Joy O

GBM treatment
Infection
Radiation necrosis

This systematic review examined the oncologic outcomes and toxicities of intraoperative radiation therapy (IORT) for glioblastoma (GBM). IORT resulted in improved local control and comparable overall survival rates with the Stupp protocol. While photon-based IORT showed better results than electron-based IORT, further research is needed to confirm its efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

[The role of proton therapy in esophageal cancer].

Author: CréhangeG, GoudjilF, KrhiliS L, MinsatM, de MarziL, DendaleR

Esophageal cancer treatment

Proton beam radiation therapy (PT) has potential advantages over photon radiation therapy for esophageal cancer (EC). PT may reduce dose to healthy tissue and allow for safer treatment of tumors near critical organs.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

36.

Clinical impact of extended field radiation therapy in Stage III carcinoma cervix versus conventional field techniques: A comparative study.

Author: DagaPrateek, KumarH S, SharmaNeeti, JakharShankar Lal, HarshKamlesh Kumar, DhakaSaroj

High CR rate
Minimal toxicities

This study of 50 patients with stage III carcinoma cervix treated with concurrent computed tomography (injection cisplatin 40 mg/m2) and radiation therapy found that both extended and conventional field irradiation resulted in a high complete response rate with minimal acute and late toxicities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

A systematic review of pediatric neuropsychological outcomes with proton <i>versus</i> photon radiation therapy: A call for equity in access to treatment.

Author: PetersonRachel K, KingTricia Z

Reduced neuropsychological sequelae

Proton beam radiation therapy (PRT) is increasingly used to treat pediatric brain tumors due to its presumed advantages over traditional photon radiation therapy (XRT). This systematic review aimed to provide an overview of published studies comparing neuropsychological outcomes between PRT and XRT.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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