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Efficacy of topotecan nanoparticles for intravitreal chemotherapy of retinoblastoma.

Author: AghajanpourLeila, AmoliFahimeh Asadi, AtyabiFatemeh, DelrishElham, DinarvandRassoul, GhassemiFariba, JabbarvandMahmoud, LashayAlireza, SoleimaniMasoud

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Thiolated chitosan nanoparticles containing topotecan (TPH-TCs-NPs) were fabricated to enhance drug loading and release control for retinoblastoma treatment. TPH-TCs-NPs showed enhanced efficacy and association relative to free TPH in retinoblastoma cells and tumor in vitro and in vivo.
Paper Details　
Original Abstract of the Article :
Retinoblastoma (Rb) is the most common intraocular malignancy in children that accounts for approximately 4% of all pediatric malignancies. Since chemotherapy is a widely practiced treatment for Rb, there is a growing interest in developing new and effective drugs to overcome systemic and local side...See full text at original site
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引用元：
https://doi.org/10.1016/j.exer.2020.108423

データ提供：米国国立医学図書館（NLM）

Topotecan Nanoparticles for Retinoblastoma: A New Oasis in the Treatment of Childhood Cancer

Retinoblastoma (Rb), a rare but aggressive childhood cancer, requires effective treatment strategies. This study investigates the potential of topotecan nanoparticles as a novel approach to intravitreal chemotherapy for Rb. The study employs a modified ionic gelation method to fabricate topotecan-loaded nanoparticles and evaluates their efficacy in vitro and in vivo.

A New Dawn in Retinoblastoma Treatment: The Potential of Topotecan Nanoparticles

The study demonstrates that topotecan-loaded nanoparticles exhibit enhanced efficacy compared to free topotecan in both in vitro and in vivo models of Rb. The nanoparticles show improved cell association, increased treatment efficacy, and overcome the challenges associated with traditional intravitreal administration of topotecan. These findings offer a promising avenue for developing more effective and targeted treatments for Rb.

Hope for Children: A Journey Towards Better Treatments

This study represents a significant step forward in the fight against Rb. The potential of topotecan nanoparticles to improve treatment efficacy and overcome the limitations of traditional therapies offers a beacon of hope for children diagnosed with this aggressive cancer. The study underscores the importance of embracing innovative approaches to develop better treatments for childhood cancers.

Dr. Camel's Conclusion

This research is a beacon of hope in the vast desert of childhood cancers. The development of topotecan nanoparticles offers a promising new approach to treating Rb, potentially improving treatment outcomes and minimizing the side effects associated with traditional therapies. The study underscores the importance of embracing innovative approaches to develop better treatments for childhood cancers. Just as a camel navigates a challenging desert landscape, we must be persistent and adaptable in our pursuit of better treatments for children with cancer. We must continue our journey of discovery, seeking new oases of hope in the fight against these debilitating diseases.
Date :
  1. Date Completed 2021-08-27
  2. Date Revised 2021-08-27
Further Info :

Pubmed ID

33453276

DOI: Digital Object Identifier

10.1016/j.exer.2020.108423

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SNS
PICO Info
in preparation
Languages

English

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