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Differential effects of quinine adulteration of alcohol on seeking and drinking.

Author: AutersonCurtis D, CzachowskiCristine L, DeLoryMichael J, LapishChristopher C, McCaneAqilah M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigates the relationship between genetic vulnerability to alcohol dependence and alcohol-seeking and drinking behaviors in alcohol-preferring P rats compared to Wistar rats. Results indicate that genetically vulnerable rats (P rats) learned faster and consumed more alcohol, highlighting the potential utility of P rats in examining neural mechanisms associated with alcohol dependence.
Paper Details　
Original Abstract of the Article :
Alcohol dependence is characterized by compulsive alcohol use. Alcohol-paired stimuli can drive compulsive alcohol use, induce craving, and lead to relapse. Alcohol dependence is highly heritable, and individuals with a family history are at elevated risk to develop an alcohol use disorder. Understa...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/33465465

データ提供：米国国立医学図書館（NLM）

Alcohol Dependence: A Journey Through the Desert of Addiction

This study explores the genetic and neural mechanisms underlying alcohol dependence, a complex condition characterized by compulsive alcohol use. The researchers investigated the behavior of alcohol-preferring rats (P rats) and their progenitor strain, Wistar rats, to understand how genetic predisposition influences alcohol-seeking and drinking behaviors. The study delves into the neural pathways that contribute to addiction, revealing clues about the desert of alcohol dependence.

Unveiling Genetic Differences: A Desert of Diverse Landscapes

The study found that P rats, genetically predisposed to alcohol dependence, exhibited increased motivated behaviors and consumed more alcohol than their Wistar counterparts. This is like finding two different oases in the desert, each with its own unique flora and fauna. The study highlights the importance of considering genetic factors in understanding the complexities of alcohol dependence.

Targeting Addiction: A Desert Survival Guide for the Mind

This study provides valuable insights into the neural mechanisms underlying alcohol dependence. The research underscores the importance of understanding how genetic predisposition and environmental factors interact to shape addictive behaviors. This is like navigating a treacherous desert, requiring a deep understanding of the landscape and the ability to adapt to changing conditions.

Dr. Camel's Conclusion

This study offers a glimpse into the complex world of alcohol dependence. The research highlights the importance of considering genetic factors and the need to develop targeted interventions for individuals at risk of developing alcohol use disorder. It is like a camel caravan traversing a vast and challenging desert, requiring knowledge, resilience, and a commitment to finding a path to recovery.
Date :
  1. Date Completed 2021-09-23
  2. Date Revised 2022-05-03
Further Info :

Pubmed ID

33465465

DOI: Digital Object Identifier

NIHMS1665008

Related Literature

Article Analysis
・Effects of quinine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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