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Rivastigmine Transdermal Patch Treatment for Moderate to Severe Cognitive Impairment in Veterans with Traumatic Brain Injury (RiVET Study): A Randomized Clinical Trial.

Author: ArciniegasDavid B, BizienMarcel, Brawman-MintzerOlga, DonovanKeaveny, HamnerMark, HarveyPhilip D, HornerMichael D, Johnson-GreeneLisa, JorgeRicardo E, KindyArianne Z, MartineauR Jared, McGaritySuzanne, MintzerJacobo, RaskindMurray, RedaDomenic, Rodriguez-SuarezMercedes, SindowskiTom, TangX Charlene, WeiYongliang, WortzelHal S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Rivastigmine patches were tested in veterans with traumatic brain injuries (TBI) and memory impairment. The trial showed no improvement in memory function compared to placebo. However, this study involved the largest sample of veterans with TBI enrolled in a pharmacological trial to date.
Paper Details　
Original Abstract of the Article :
Cognitive impairment is common in veterans with histories of traumatic brain injury (TBI). Cholinergic deficits have been hypothesized as contributors to this impairment. We report the effects of cholinesterase inhibitor rivastigmine transdermal patch treatment in veterans with TBI and post-traumati...See full text at original site
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引用元：
https://doi.org/10.1089/neu.2020.7146

データ提供：米国国立医学図書館（NLM）

Rivastigmine Patch Treatment for Traumatic Brain Injury: A Randomized Clinical Trial

This research evaluates the efficacy and safety of [rivastigmine transdermal patches] for treating [cognitive impairment] in veterans with [traumatic brain injury (TBI)]. The authors conducted a [randomized clinical trial] to assess the impact of rivastigmine on [memory impairment] in this specific population. Despite a large sample size, the study found no significant difference in treatment effects between rivastigmine and placebo groups. This suggests that rivastigmine patches, while generally safe, may not be an effective treatment for cognitive impairment in veterans with TBI.

Seeking Solutions for TBI: Challenges and Future Directions

This research highlights the ongoing challenge of finding effective treatments for [cognitive impairment] in veterans with [traumatic brain injury (TBI)]. The results, while not conclusive, provide valuable data for further investigation. The study's large sample size and thorough methodology contribute to the understanding of the complexities of TBI and the need for more targeted treatments.

Navigating the Aftermath of Trauma: Finding Hope for Cognitive Recovery

The desert of traumatic brain injury (TBI) can be vast and unforgiving, leaving many veterans struggling with cognitive impairments. This research, while not offering a definitive solution, provides important insights into the challenges and potential avenues for treatment. It is a step towards understanding the complex interplay of brain injury, cognitive function, and the search for effective therapies.

Dr. Camel's Conclusion

This research sheds light on the ongoing challenges of treating cognitive impairment in veterans with TBI. It's like navigating a vast, shifting desert of symptoms and treatments, searching for a pathway to recovery. While the results do not offer a definitive solution, they provide valuable information for future research and highlight the ongoing need for effective therapies.
Date :
  1. Date Completed 2022-02-21
  2. Date Revised 2022-02-21
Further Info :

Pubmed ID

33514274

DOI: Digital Object Identifier

10.1089/neu.2020.7146

Related Literature

Article Analysis
・Effects of rivastigmine transdermal patch
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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