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Perils of prolonged ovarian suppression and hypoestrogenism in the treatment of breast cancer: Is the risk of treatment worse than the risk of recurrence?

Author: CastracaneV Daniel, KauffmanRobert P, YoungChristina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Prolonged ovarian suppression in premenopausal women with estrogen receptor positive breast cancer is standard practice for reducing recurrence risk. While it benefits disease-free survival, it also carries risks of long-term hypoestrogenism, including quality of life issues and increased mortality.
Paper Details　
Original Abstract of the Article :
Premenopausal breast cancer is usually estrogen receptor positive, and hence, prolonged ovarian suppression by medical or surgical means to prevent recurrence has become standard of management to improve disease-free survival. Ten-year adjuvant tamoxifen therapy is associated with 3.5% fewer recurre...See full text at original site
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引用元：
https://doi.org/10.1016/j.mce.2021.111181

データ提供：米国国立医学図書館（NLM）

Prolonged Ovarian Suppression: Navigating the Complexities of Breast Cancer Treatment

Breast cancer, a formidable desert landscape, requires a carefully planned strategy for treatment. This study, like a wise guide navigating the complexities of breast cancer management, examines the potential risks and benefits of prolonged ovarian suppression in premenopausal women. The researchers, like skilled cartographers, explore the impact of prolonged hypoestrogenism on both cancer recurrence and overall health.

Balancing Risks and Benefits: A Delicate Equation in Breast Cancer Treatment

The study highlights the delicate balance between reducing cancer recurrence and preserving long-term health in premenopausal breast cancer patients. While prolonged ovarian suppression can significantly reduce the risk of recurrence, it can also lead to a range of adverse effects related to hypoestrogenism, such as cardiovascular disease, bone loss, and cognitive decline.

Personalized Treatment Strategies: A Path Towards Better Outcomes

This research, like a beacon guiding towards a more personalized approach, underscores the need for individualized treatment plans for premenopausal breast cancer patients. By carefully weighing the risks and benefits of prolonged ovarian suppression, clinicians can develop treatment strategies that optimize outcomes while minimizing long-term health consequences.

Dr.Camel's Conclusion

This study, like a map illuminating the intricate pathways of breast cancer treatment, emphasizes the importance of balancing the risks and benefits of prolonged ovarian suppression. The findings provide valuable insights for developing personalized treatment strategies that prioritize both cancer control and long-term well-being.

Date :
  1. Date Completed 2021-10-06
  2. Date Revised 2021-10-06
Further Info :

Pubmed ID

33529690

DOI: Digital Object Identifier

10.1016/j.mce.2021.111181

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English

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