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A Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body Composition, and Metabolic Profile in Transmen.

Author: AlvisiStefania, ArmillottaFrancesca, GavaGiulia, GiagioSilvia, ManciniIlaria, MeriggiolaMaria Cristina, MorselliPaolo Giovanni, PillastriniPaolo, SeracchioliRenato

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This randomized, double-blind placebo-controlled pilot trial found that testosterone undecanoate (TU) combined with the 5α-reductase inhibitor dutasteride (DT) or placebo (PL) resulted in similar increases in muscle strength, decreases in fat mass, and increases in lean mass in ovariectomized transmen. These findings suggest that the conversion of testosterone to dihydrotestosterone may not be essential for muscle growth in transmen.
Paper Details　
Original Abstract of the Article :
BACKGROUND: While the effects of androgens on muscle are well described in hypogonadal men, literature is still scarce on muscular strength or size variations in transmen; in this population there are no data regarding the relative effect of testosterone (T) and its metabolite dihydrotestosterone on...See full text at original site
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引用元：
https://doi.org/10.1016/j.jsxm.2020.12.015

データ提供：米国国立医学図書館（NLM）

Muscle Strength and Body Composition in Transmen: A Study on Testosterone Undecanoate and Dutasteride

The world of [Transgender Healthcare] is constantly evolving, with new research emerging all the time. This study delves into the [impact of androgens on muscle strength and body composition] in transmen. This research, like finding a spring in the desert, offers valuable insights into this specific population. The authors [conducted a randomized double-blind placebo-controlled trial] to investigate the [effects of testosterone undecanoate (TU) and dutasteride (DT) on muscle strength, body composition, and metabolic profile]. It's like examining the effects of different types of fertilizers on a desert garden, carefully analyzing the growth and development of the plants.

A Deeper Understanding of Androgen Effects in Transmen

The results demonstrate that [TU combined with DT or placebo] significantly [increased handgrip and lower limb strength] in transmen. Interestingly, both groups also experienced [similar changes in body composition]. This is like observing the [growth of a desert plant] after applying different fertilizers - both fertilizers contribute to growth, but the specific impact may vary.

Living Well with Testosterone Therapy

This research offers [essential insights into the effects of testosterone therapy] in transmen. While the study shows [positive benefits in terms of muscle strength and body composition], it is crucial for individuals to [consult with healthcare professionals] for personalized guidance and monitoring.

Dr.Camel's Conclusion

This study is a significant step forward in our understanding of the effects of testosterone therapy in transmen. It highlights the potential benefits of TU with DT while also emphasizing the need for continued research and personalized care. As we continue to learn more about the vast desert of transgender healthcare, we can better support the unique needs of individuals transitioning.

Date :
  1. Date Completed 2021-04-20
  2. Date Revised 2021-04-20
Further Info :

Pubmed ID

33531255

DOI: Digital Object Identifier

10.1016/j.jsxm.2020.12.015

Related Literature

Article Analysis
・Effects of dutasteride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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