Effects of dutasteride: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major Research Findings

Dutasteride is a medication used to treat various conditions such as male pattern baldness, benign prostatic hyperplasia (BPH), prostate cancer, and bladder cancer. 13 、 6 、 11 、 1 、 16 、 12 、 5 、 19 、 20 、 9 、 15 、 17 、 14 、 3 、 10 It works by inhibiting the enzyme 5α-reductase, which reduces the production of dihydrotestosterone (DHT), a hormone responsible for prostate growth and male pattern baldness. 13 、 6 、 11 、 1 、 16 、 12 、 5 、 19 、 20 、 9 、 15 、 17 、 14 、 3 、 10

Multiple studies have shown dutasteride to be effective in treating BPH. 16 、、 7 、 5 、 19 、 20 、 9 、 14 Dutasteride can reduce prostate size and improve urinary symptoms. 16 、、 7 、 5 、 19 、 20 、 9 、 14

Dutasteride may also be effective in treating male pattern baldness. 13 By inhibiting DHT production, dutasteride could potentially promote hair growth. 13

However, dutasteride can cause side effects such as sexual dysfunction. 13 、 18 、 15

Dutasteride is also used in the treatment of prostate cancer. 6 、 1 、 11 、 3 By reducing DHT production, it may slow down the progression of prostate cancer. 6 、 1 、 11 、 3

Dutasteride may also be beneficial in treating bladder cancer. 3 By reducing DHT levels, it could potentially slow down the progression of bladder cancer. 3

Benefits and Risks

Benefit Summary

Dutasteride has the potential to be effective in treating conditions such as BPH, male pattern baldness, prostate cancer, and bladder cancer. 16 、、 7 、 5 、 19 、 20 、 9 、 14 、 6 、 1 、 11 、 3 By reducing DHT production, dutasteride could potentially slow down the progression of these conditions. 16 、、 7 、 5 、 19 、 20 、 9 、 14 、 6 、 1 、 11 、 3 As a treatment for BPH, dutasteride may help improve urinary symptoms. 16 、、 7 、 5 、 19 、 20 、 9 、 14

Risk Summary

Dutasteride can cause side effects, including sexual dysfunction. 13 、 18 、 15

Comparison of Studies

Commonalities in Studies

Many studies show that dutasteride is effective in treating BPH. 16 、、 7 、 5 、 19 、 20 、 9 、 14

Many studies also indicate that dutasteride can cause side effects, such as sexual dysfunction. 13 、 18 、 15

Differences in Studies

Research on the effectiveness and side effects of dutasteride varies based on the targeted conditions and study designs. For example, in treating BPH, dutasteride effectiveness is assessed using urodynamic studies, serum hormone level measurements, and prostate volume measurements. Regarding side effects, sexual dysfunction has been reported, but the frequency and severity can differ across studies. 16 、、 7 、 5 、 19 、 20 、 9 、 14 、 13 、 18 、 15

Consistency and Contradictions in Results

The research findings on the effectiveness of dutasteride are consistent. Many studies show that dutasteride is effective in treating BPH. However, there are some contradictions in research findings on dutasteride side effects. Some studies show that dutasteride can cause side effects such as sexual dysfunction, while others do not report such side effects. 13 、 18 、 15

Points to Note Regarding Real-Life Application

Dutasteride is a medication used to treat BPH, male pattern baldness, and prostate cancer. 13 、 18 、 15 By reducing DHT production, dutasteride could potentially slow down the progression of these conditions. 13 、 18 、 15 However, dutasteride can cause side effects such as sexual dysfunction. 13 、 18 、 15

When using dutasteride, it is essential to discuss these side effects with your doctor and exercise caution. Dutasteride should not be used by pregnant or breastfeeding women. 13 、 18 、 15

Limitations of Current Research

There is still insufficient research on the effects of dutasteride. Long-term effects, in particular, need further investigation. 18

Furthermore, there are contradictions in the research findings on dutasteride side effects. Further research on dutasteride side effects is necessary. 13 、 18 、 15

Future Research Directions

Research is needed to investigate the long-term effects of dutasteride use. Also, research should address the contradictions in findings regarding dutasteride side effects. 18

Additionally, research is needed to investigate the interactions of dutasteride with other medications. 5

Conclusion

Dutasteride has the potential to be effective in treating BPH, male pattern baldness, prostate cancer, and bladder cancer. 16 、、 7 、 5 、 19 、 20 、 9 、 14 、 6 、 1 、 11 、 3

However, dutasteride can cause side effects such as sexual dysfunction. 13 、 18 、 15

When using dutasteride, it is essential to discuss these side effects with your doctor and exercise caution. 13 、 18 、 15

Literature analysis of 20 papers
Positive Content
16
Neutral Content
2
Negative Content
2
Article Type
3
2
2
3
20
1.

Effect of dutasteride on intraprostatic androgen levels in men with benign prostatic hyperplasia or prostate cancer.

Author: RittmasterRoger, HahnRobert G, RayPaul, ShannonJennifer B, WurzelRafael

Suppresses DHT

Dutasteride, a medication used to treat enlarged prostates, reduced levels of dihydrotestosterone (DHT) in the prostate and serum.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer.

Author: SeokJaekwon, KwakHee Jeong, KwakYeonjoo, LeeMoonjung, ParkKyoung Sik, KimAram, ChoSsang-Goo

BCa treatment development

Bladder cancer (BCa) is more common in men than women. This study aims to understand the differences in BCa control mechanisms based on gender. Previous clinical studies showed that androgen suppression therapy can affect BCa progression, but the underlying mechanisms are still unknown.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Inhibitory Effects of Dutasteride on TLR4: An In vitro Pain Study.

Author: TaheranLeila, ZaliHakimeh, SharifiKazem, YazdaniMohsen, AjoudanianMohammad, SafariMir-Shahram, RajaeiSamira, DabbaghAli

Anti-inflammatory
Pain control

Dutasteride, a 5α-reductase inhibitor, demonstrated anti-inflammatory properties by inhibiting Toll-Like Receptor 4 (TLR4) signaling in LPS-stimulated U-87 MG cells. It reduced the levels of TLR4, MyD88, and NF-κBp65, suggesting its potential analgesic effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Effects of Curcumin Combined With the 5-alpha Reductase Inhibitor Dutasteride on LNCaP Prostate Cancer Cells.

Author: NakayamaAkinori, IdeHisamitsu, LuYan, TakeiAyano, FukudaKazunori, OsakaAkiyoshi, AraiGaku, HorieShigeo, OkadaHiroshi, SaitoKazutaka

Inhibits prostate cancer

Curcumin, a turmeric compound, has been shown to inhibit prostate cancer cell growth. This study investigated the effects of combining curcumin with dutasteride, a 5-alpha reductase inhibitor, on prostate cancer cell proliferation and testosterone/dihydrotestosterone levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Effects of dutasteride on sex hormones and cerebrospinal steroids in patients treated for benign prostatic hyperplasia.

Author: FavillaVincenzo, CannarellaRossella, TrovatoFederica, Li VoltiGiovanni, DistefanoAlfio, GrimaldiEnrico, La CameraGiuseppa, La VigneraSandro, CondorelliRosita A, CalogeroAldo E, CiminoSebastiano

ED
HSD

This case-control study assessed whether dutasteride, a 5α-reductase inhibitor, impacts the levels of neuroactive steroids, leading to erectile dysfunction (ED) and/or hypoactive sexual desire (HSD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body Composition, and Metabolic Profile in Transmen.

Author: GavaGiulia, ArmillottaFrancesca, PillastriniPaolo, GiagioSilvia, AlvisiStefania, ManciniIlaria, MorselliPaolo Giovanni, SeracchioliRenato, MeriggiolaMaria Cristina

Fat mass reduction
Lean mass increase
Muscle strength improvement
Cutaneous androgenic effects

This randomized, double-blind placebo-controlled pilot trial found that testosterone undecanoate (TU) combined with the 5α-reductase inhibitor dutasteride (DT) or placebo (PL) resulted in similar increases in muscle strength, decreases in fat mass, and increases in lean mass in ovariectomized transmen. These findings suggest that the conversion of testosterone to dihydrotestosterone may not be essential for muscle growth in transmen.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effects of dutasteride in a rat model of chemically induced prostatic inflammation-Potential role of estrogen receptor β.

Author: MizoguchiShinsuke, MoriKenichi, ShinToshitaka, WangZhou, DeFrancoDonald B, YoshimuraNaoki, MimataHiromitsu

Lower urinary tract symptoms improvement

Dutasteride has been shown to improve lower urinary tract symptoms in men with prostatic inflammation. This study investigates the effect of dutasteride on intraprostatic inflammatory responses and bladder activity in a rat model of prostatic inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Concentration-dependent effects of dutasteride on prostate-specific membrane antigen (PSMA) expression and uptake of <sup>177</sup> Lu-PSMA-617 in LNCaP cells.

Author: KranzbühlerBenedikt, SalemiSouzan, UmbrichtChristoph A, DeberleLuisa M, MüllerCristina, BurgerIrene A, HermannsThomas, SulserTullio, EberliDaniel

Dutasteride effects
PSMA expression increase
Low PSMA surface expression

Dutasteride, a 5α-reductase inhibitor, has been shown to increase PSMA expression in vitro. This study further investigates the concentration- and time-dependent effects of dutasteride on PSMA expression in LNCaP cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Computer vision detects subtle histological effects of dutasteride on benign prostate.

Author: SethiAmit, ShaLingdao, KumarNeeraj, MaciasVirgilia, DeatonRyan J, GannPeter H

Dutasteride response detection

A computer vision approach can detect subtle histological effects attributable to dutasteride.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

A Systematic Review and Meta-Analysis of the Effects on Dutasteride Treatment for Reducing Surgical Blood Loss during Transurethral Resection of the Prostate.

Author: RenJian, LaiShicong, JiangZhaoqiang, XuXin, DiaoTongxiang, ThiruchelvamNikesh, ZhangGuan

Reduced bleeding

This systematic review and meta-analysis evaluated the efficacy of preoperative dutasteride treatment for reducing surgical blood loss in patients undergoing transurethral resection of the prostate (TURP). The study found that preoperative treatment with dutasteride could reduce surgical bleeding during TURP, but the findings of this study should be further confirmed by well-designed prospective RCTs with a larger patient series.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review.

Author: HirshburgJason M, KelseyPetra A, TherrienChelsea A, GavinoA Carlo, ReichenbergJason S

Hair loss treatment
Prostate cancer
Psychological effects
Sexual health

Finasteride and dutasteride, 5-alpha reductase inhibitors, are commonly used to treat androgenetic hair loss in men and women. This abstract reviews the adverse effects of these drugs, including possible risks of prostate cancer, psychological effects, sexual health issues, and potential risks for women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Effects of dutasteride on lower urinary tract symptoms: a prospective analysis based on changes in testosterone/dihydrotestosterone levels and total prostatic volume reduction.

Author: ShigeharaKazuyoshi, MiyagiTohru, NakashimaTakao, IzumiKoji, KitagawaYasuhide, MizokamiAtsushi, KohEitetsu, ShimamuraMasayoshi, NamikiMikio

Improved voiding symptoms

Dutasteride treatment reduced total prostate volume (TPV) in patients with benign prostatic hyperplasia. Some patients with smaller TPV reductions experienced improvement in voiding symptoms due to increased testosterone levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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