Paper Details

  1. Home
  2. Paper Details

Interaction of cannabidiol with other antiseizure medications: A narrative review.

Author: DowdZoya, GilmartinChristopher G S, HarijanPooja, ParkerAlasdair P J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review of 30 studies found that pharmacokinetic and pharmacodynamic interactions exist between cannabidiol (CBD) and antiseizure medications (ASMs). The cytochrome p450 system is particularly involved in pharmacokinetic interactions. More research is needed to fully understand these interactions.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Cannabidiol is efficacious as an adjunctive treatment in children with epilepsy associated with Dravet and Lennox-Gastaut syndromes. As its role is currently adjunctive, we reviewed the interactions of cannabidiol with other antiseizure medications (ASMs). METHODS: A search of Cochrane, ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.seizure.2020.09.010

データ提供：米国国立医学図書館（NLM）

Cannabidiol and Antiseizure Medications: A Complex Interplay

Cannabidiol (CBD) has emerged as a promising adjunctive treatment for children with epilepsy. This research investigates the potential interactions between CBD and other antiseizure medications (ASMs), examining both pharmacokinetic and pharmacodynamic mechanisms. The authors conduct a narrative review to synthesize the available evidence on these interactions.

A Complex Dance: CBD's Interactions with ASMs

The review identifies potential for both pharmacokinetic and pharmacodynamic interactions between CBD and various ASMs, including brivaracetam, clobazam, eslicarbazepine, lacosamide, gabapentin, oxcarbazepine, phenobarbital, potassium bromide, pregabalin, rufinamide, sirolimus/everolimus, stiripentol, tiagabine, topiramate, and zonisamide. The cytochrome p450 system plays a significant role in these interactions, but other mechanisms may also be involved.

Navigating the Interactions: Ensuring Safe and Effective Treatment

This review underscores the importance of careful monitoring for interactions between CBD and ASMs. Clinicians should be aware of the potential for these interactions and adjust treatment accordingly. Monitoring blood levels may be necessary to ensure safe and effective treatment for patients using both CBD and ASMs.

Dr. Camel's Conclusion

Just as a camel navigates a maze of shifting sand dunes, we must carefully consider the complex interactions between CBD and ASMs. This review provides valuable insights into these interactions, highlighting the importance of vigilance and collaboration between clinicians and patients to ensure safe and effective treatment for individuals with epilepsy.

Date :
  1. Date Completed 2021-07-12
  2. Date Revised 2021-07-12
Further Info :

Pubmed ID

33541771

DOI: Digital Object Identifier

10.1016/j.seizure.2020.09.010

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.