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Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis.

Author: BrambillaPaolo, De RonchiDiana, Del FabroLorenzo, DelvecchioGiuseppe, FanelliGiuseppe, LippiMatteo, OlivaVincenzo, PaciRiccardo, SerrettiAlessandro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis evaluated short-term rates of gastrointestinal side effects (SEs) in major depressive disorder (MDD) patients treated with second-generation antidepressants. Escitalopram and sertraline showed the highest rates of SEs, while mirtazapine had fewer gastrointestinal side effects.
Paper Details　
Original Abstract of the Article :
Gastrointestinal side effects (SEs) are frequently observed in patients with major depressive disorder (MDD) while taking antidepressants and may lead to treatment discontinuation. The aim of this meta-analysis is to provide quantitative measures on short-term rates of gastrointestinal SEs in MDD pa...See full text at original site
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引用元：
https://doi.org/10.1016/j.pnpbp.2021.110266

データ提供：米国国立医学図書館（NLM）

Gastrointestinal Side Effects of Antidepressants: A Systematic Review

The world of mental health is constantly evolving, with research consistently uncovering new insights into treatment approaches. This study dives into the realm of antidepressant therapy, examining the common gastrointestinal side effects associated with different types of antidepressants in patients with major depressive disorder (MDD).

The researchers conducted a systematic review and meta-analysis of 304 studies, focusing on the gastrointestinal side effects of 15 commonly used second-generation antidepressants. The meta-analysis aimed to quantify the short-term rates of these side effects, providing valuable information for clinicians prescribing antidepressants.

Understanding the Gastrointestinal Impact

The meta-analysis revealed that all the considered antidepressants were associated with higher rates of gastrointestinal side effects compared to placebo. Escitalopram and sertraline were identified as the antidepressants with the highest rates of gastrointestinal side effects, while mirtazapine was associated with fewer side effects on the gut.

Balancing Benefits and Side Effects

Antidepressants play a crucial role in managing major depressive disorder, but it is essential to consider the potential side effects, particularly gastrointestinal issues. This research highlights the importance of individualized treatment approaches, taking into account each patient's unique needs and potential risks. By carefully considering the gastrointestinal tolerability profiles of different antidepressants, clinicians can make informed decisions that maximize treatment effectiveness while minimizing discomfort.

Dr.Camel's Conclusion

Navigating the desert of depression treatment can feel like traversing a labyrinth of options and potential side effects. This research sheds light on the gastrointestinal landscape of antidepressant therapy, emphasizing the importance of understanding the individual tolerability of different medications. By carefully considering this information, clinicians can help patients find the oasis of effective treatment with minimal side effects.

Date :
  1. Date Completed 2022-02-07
  2. Date Revised 2022-02-07
Further Info :

Pubmed ID

33549697

DOI: Digital Object Identifier

10.1016/j.pnpbp.2021.110266

SNS
PICO Info
in preparation
Languages

English

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