Side Effects of vortioxetine: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Main Research Findings

Vortioxetine is a novel antidepressant that has shown promise in treating major depressive disorder (MDD). It is generally well-tolerated and has a unique mechanism of action that targets multiple neurotransmitter systems. 7 , 22 , 13 , 6

Reasons for Side Effects

The side effects of vortioxetine are likely due to its modulation of serotonin activity. Serotonin is a neurotransmitter that plays a role in mood, appetite, sleep, learning, and memory. By regulating serotonin levels, vortioxetine can improve depressive symptoms, but it can also impact these functions. As a result, side effects such as mood changes, gastrointestinal problems, and sexual dysfunction can occur. 11

Common Side Effects

Gastrointestinal Side Effects

One of the most common side effects of vortioxetine is gastrointestinal problems. These side effects can include nausea, vomiting, diarrhea, constipation, and abdominal pain. Vortioxetine may affect the functions of the gastrointestinal tract by regulating serotonin activity. As a result, these side effects can occur when taking vortioxetine. These side effects typically lessen after a few weeks of treatment. 13 , 19

Other Side Effects

In addition to gastrointestinal side effects, vortioxetine can cause various other side effects. These side effects can include sexual dysfunction, sleepiness, headache, dizziness, dry mouth, and weight gain. 20 , 24 , 9 , 3

Side Effect Management

Gastrointestinal Side Effect Management

To reduce gastrointestinal side effects, you can try dietary changes and lifestyle modifications. Dietary changes include eating small meals more frequently, avoiding fatty foods, and eating foods high in fiber. Lifestyle modifications include maintaining a regular sleep schedule, getting enough sleep, and managing stress. If these measures don't help, consult your doctor. 13 , 19

Other Side Effect Management

To manage other side effects, consult your doctor. They can identify the cause of the side effects and recommend appropriate treatment. 20 , 24 , 9 , 3

Comparison Across Studies

Commonalities Across Studies

Numerous studies have shown that vortioxetine is effective in treating depression. It is also generally considered to have fewer side effects compared to other antidepressants. 7 , 22 , 13 , 6

Differences Across Studies

The effectiveness and side effects of vortioxetine can vary from person to person. Therefore, it is essential to consider each patient's individual circumstances when evaluating the effects and side effects of vortioxetine. 7 , 22 , 13 , 6

Considerations for Real-World Applications

Vortioxetine is an effective medication for treating depression, but it also carries the risk of side effects. When taking vortioxetine, it is crucial to discuss the risks and benefits thoroughly with your doctor. 7 , 22 , 13 , 6

Limitations of Current Research

Research on vortioxetine is still limited, and long-term effects and side effects are not fully understood. Therefore, it is essential to consult your doctor when taking vortioxetine. 7 , 22 , 13 , 6

Future Research Directions

Research is needed to evaluate the long-term effects and side effects of vortioxetine. Research is also needed to investigate how the effects and side effects of vortioxetine change due to interactions with other medications. 7 , 22 , 13 , 6

Conclusion

Vortioxetine is a new type of antidepressant that is effective for treating depression. It is generally considered to have fewer side effects compared to other antidepressants. However, research on vortioxetine is still limited, and long-term effects and side effects are not fully understood. When taking vortioxetine, it is crucial to discuss the risks and benefits thoroughly with your doctor. 7 , 22 , 13 , 6

Literature analysis of 24 papers
Positive Content
20
Neutral Content
1
Negative Content
3
Article Type
2
6
5
5
22
1.

Vigabatrin for refractory partial epilepsy.

Author: HemmingKarla, MaguireMelissa J, HuttonJane L, MarsonAnthony G

Epilepsy treatment
Visual field constriction

Vigabatrin, an antiepileptic drug for refractory epilepsy, is generally well-tolerated. However, long-term use has been associated with asymptomatic visual field constriction, highlighting the need for monitoring during treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Vigabatrin for refractory partial epilepsy.

Author: HemmingKarla, MaguireMelissa J, HuttonJane L, MarsonAnthony G

Refractory epilepsy treatment
Visual field constriction

Vigabatrin is an antiepileptic drug that is used for the treatment of refractory epilepsy. Although vigabatrin is generally well tolerated, it can cause asymptomatic visual field constriction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD).

Author: NgChong Guan, AbousheishaaAya Ahmed, LowSue Yin, ZainalNor Zuraida, ThongKai Shin, AwaluddinAzizul Bin, LooTsui Huei, YacobSapini Binti, Nik JaafarNik Ruzyanei, Abdul TaibNur Iwana Abdul, Mohamad KamalNurul Ain Binti, IsmailFuad, Zamaniah WiWan

Cognitive function improvement
Depression reduction
Quality of life improvement
Dry mouth
Headache
Insomnia
Somnolence

Vortioxetine seems promising in the management of depression and enhancement of cognitive function and quality of life of cancer patients with Major Depressive Disorder.

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Exploring depression in Alzheimer's disease: an Italian Delphi Consensus on phenomenology, diagnosis, and management.

Author: PadovaniAlessandro, AntoniniAngelo, BaronePaolo, BellelliGiuseppe, FagioliniAndrea, Ferini StrambiLuigi, SorbiSandro, StocchiFabrizio

Depression treatment

The aim of this Delphi study is to reach a shared point of view among different Italian specialists on depression in Alzheimer's disease (AD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

A comprehensive review and meta-analysis of neurological side effects related to second-generation antidepressants in individuals with major depressive disorder.

Author: ZhouQi, LiXinming, YangDejiang, XiongChongyu, XiongZhenrong

Depression treatment
Neurological side effects

This meta-analysis found that most second-generation antidepressants increase the risk of neurological side effects compared to placebo. Agomelatine, bupropion, and vortioxetine showed a reduced risk of specific neurological side effects.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Vortioxetine Induced Hypomania: A Case Presentation and Review of the Literature.

Author: TuncEce Buyuksandalyaci, TuncSerhat

Hypomania risk
Mania risk

This case report presents a case of vortioxetine-induced hypomania in a major depressive disorder patient. The report adds to the literature on vortioxetine-induced mania and hypomania.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

8.

Case Report: Vortioxetine in the Treatment of Depressive Symptoms in Patients With Epilepsy-Case Series.

Author: SiwekMarcin, GorostowiczAleksandra, BosakMagdalena, DudekDominika

Depression remission
Good tolerability
Low interaction risk
Safe for comorbidities
Pregnancy planning
Seizures

Epilepsy and depression often occur together, and this study reports on nine patients with epilepsy and depression who were treated with the antidepressant vortioxetine. The results suggest that vortioxetine may be a safe and effective treatment option for depression in patients with epilepsy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

10.

A Taiwanese study on real-world evidence with vortioxetine in patients with major depression in Asia (TREVIDA).

Author: YangYen Kuang, ChenCheng-Sheng, TsaiChia-Fen, ChangChia-Ming, LaiTe-Jen, LeeChun-Te, LinChih-Chien, LanTsuo-Hung, HerrKeira Joann

Improved cognitive function
Improved functioning
Improved work productivity
Reduced depression severity

This non-interventional, prospective, multi-site study evaluated the efficacy and safety of vortioxetine for the treatment of major depressive disorder (MDD) in Taiwanese adults. The study found that vortioxetine significantly reduced depression severity and improved cognitive function, work productivity, and functioning. Vortioxetine was well-tolerated in this Taiwanese population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Vortioxetine Derivatives with Amino Acid as Promoiety: Synthesis, Activity, Stability and Preliminary Pharmacokinetic Study.

Author: MoXianwei, LiYuanyuan, ZhuXinying, LiXiaolei, ZhouHaiyan, BiXinzhou, LiJing

Improved pharmacokinetics
Longer half-life
Reduced nausea

This study investigated eight amino acid modified derivatives of vortioxetine (Vot), an antidepressant, to potentially reduce gastrointestinal side effects. The study found that some derivatives showed improved pharmacokinetic properties and lower activity toward the serotonin transporter.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Focus on Depression in Parkinson's Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics.

Author: Agüera-OrtizLuis, García-RamosRocío, Grandas PérezFrancisco J, López-ÁlvarezJorge, Montes RodríguezJosé Manuel, Olazarán RodríguezF Javier, Olivera PueyoJavier, Pelegrín ValeroCarmelo, Porta-EtessamJesús

Improved depression symptoms
Side effects

This study used a modified Delphi survey to assess the knowledge and understanding of depression in Parkinson’s disease among experts in the field. The results provide guidance for the diagnosis and treatment of depression in patients with Parkinson’s disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis.

Author: OlivaVincenzo, LippiMatteo, PaciRiccardo, Del FabroLorenzo, DelvecchioGiuseppe, BrambillaPaolo, De RonchiDiana, FanelliGiuseppe, SerrettiAlessandro

Antidepressant efficacy
Gastrointestinal side effects

This meta-analysis evaluated short-term rates of gastrointestinal side effects (SEs) in major depressive disorder (MDD) patients treated with second-generation antidepressants. Escitalopram and sertraline showed the highest rates of SEs, while mirtazapine had fewer gastrointestinal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Clinical Switching Strategies of Various Antidepressants to Vortioxetine in the PREDDICT Trial.

Author: MillsNatalie T, SampsonEmma, FourrierCélia, BauneBernhard T

This abstract describes the PREDDICT study, which investigates the efficacy of augmenting vortioxetine with celecoxib for patients with major depressive disorder (MDD) who experience partial response, relapse, or treatment resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases.

Author: BehlkeLauren M, LenzeEric J, CarneyRobert M

Depression treatment
Cardiovascular side effects

Depression is a common mental health condition that can affect people of all ages, including older adults. While selective serotonin reuptake inhibitors (SSRIs) are often the first-line treatment for depression, many patients do not respond to these medications. This review summarizes what is known about the cardiovascular side effects of some of the newer antidepressants, including venlafaxine, desvenlafaxine, duloxetine, milnacipran, levomilnacipran, mirtazapine, bupropion, vilazodone, vortioxetine, agomelatine, moclobemide, and ketamine-esketamine. While some of these drugs may be safe and effective alternatives for older adults and patients with cardiovascular disease, more research is needed to fully understand their safety and efficacy in these patient populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Vortioxetine versus other antidepressants in the treatment of burning mouth syndrome: An open-label randomized trial.

Author: AdamoDaniela, PecoraroGiuseppe, CoppolaNoemi, CalabriaElena, AriaMassimo, MignognaMichele

Improved BMS symptoms

This randomized open-label trial compared the efficacy and tolerability of vortioxetine with other antidepressants for the treatment of burning mouth syndrome (BMS). 150 BMS patients were randomized to receive vortioxetine, paroxetine, sertraline, escitalopram, or duloxetine. All antidepressants showed significant improvements in symptoms, but vortioxetine demonstrated a shorter latency of action and fewer adverse events compared to other antidepressants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Effectiveness, tolerability, and dropout rates of vortioxetine in comorbid depression: A naturalistic study.

Author: De CarloVera, VismaraMatteo, GranciniBenedetta, BenattiBeatrice, BosiMonica Francesca, ColomboAnna, ViganòCaterina Adele, Dell'OssoBernardo

Improved effectiveness
Gastrointestinal side effects

Vortioxetine, a novel antidepressant, showed effectiveness and tolerability in real-world settings. However, larger sample studies are needed to better characterize its effects and potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

19.

Vortioxetine in the Treatment of Mood Disorders Associated with Burning Mouth Syndrome: Results of an Open-Label, Flexible-Dose Pilot Study.

Author: AdamoDaniela, PecoraroGiuseppe, AriaMassimo, FaviaGianfranco, MignognaMichele Davide

BMS improvement
Well tolerated

Vortioxetine (VO) was efficacious and well tolerated in the treatment of burning mouth syndrome (BMS) in both first-line therapy and second-line treatment for patients who have only partially responded or have reported adverse effects to previous treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis.

Author: KrauseMarc, GutsmiedlKatharina, BighelliIrene, Schneider-ThomaJohannes, ChaimaniAnna, LeuchtStefan

Antidepressant efficacy
Limited evidence
Multiple side effects

This systematic review and network meta-analysis examined the effectiveness and safety of various treatments for major depressive disorder in older adults. The review found that several antidepressants and quetiapine (an antipsychotic medication) were effective in treating depression in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults.

Author: SobierajDiana M, MartinezBrandon K, HernandezAdrian V, ColemanCraig I, RossJoseph S, BergKarina M, SteffensDavid C, BakerWilliam L

Adverse events
Falls

A systematic review and meta-analysis of antidepressant use in adults aged 65 years or older with major depressive disorder (MDD) revealed that serotonin-norepinephrine reuptake inhibitors (SNRIs) were associated with a statistically greater number of overall adverse events compared to placebo, while selective serotonin reuptake inhibitors (SSRIs) had a statistically similar frequency of adverse events to placebo. Both SSRI and SNRI groups showed a greater number of study withdrawals due to adverse events compared to placebo. Duloxetine, an SNRI, was linked to a higher risk of falls.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis.

Author: TomlinsonAnneka, EfthimiouOrestis, BoadenKatharine, NewEmma, MatherSarah, SalantiGeorgia, ImaiHissei, OgawaYusuke, TajikaAran, KishimotoSanae, KikuchiSino, ChevanceAstrid, FurukawaToshi A, CiprianiAndrea

Major depression treatment
Adverse events

This study presents a protocol for a network meta-analysis comparing the efficacy, adverse events, and tolerability of all second-generation and selected first-generation antidepressants in the acute treatment of major depression in adults. The study aims to extend previous findings and update the evidence base for antidepressant treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Selective Serotonin Reuptake Inhibitors.

Author: LochmannDee, RichardsonTara

More tolerable antidepressants
Safer antidepressants

SSRIs, rationally designed to be safer than previous antidepressants, are a class of psychotropic medications with varying pharmacokinetic profiles and effects on CYP450 enzymes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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