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Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation.

Author: BelloSegun, DodmanSophie, HaighRichard C, HemamiMohsen Rezaei, HoyleMartin, JaniMeghna, KharechkoAndriy, McDonaldTimothy J, RobinsonSophie, SalmonAndrew, TikhonovaIrina A, YangHuiqin

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Rheumatoid arthritis is a chronic disease that causes inflammation and pain in the joints. People with severe RA may take biologic medications, but these can be less effective if the body develops antibodies against the drug. This study discusses how doctors monitor these treatments, using clinical assessments and blood tests, to determine if adjustments are needed or to understand why treatment isn't working.
Paper Details　
Original Abstract of the Article :
Rheumatoid arthritis is a chronic autoimmune disease that primarily causes inflammation, pain and stiffness in the joints. People with severe disease may be treated with biological disease-modifying anti-rheumatic drugs, including tumour necrosis factor-α inhibitors, but the efficacy of these drugs ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898084/

データ提供：米国国立医学図書館（NLM）

Monitoring TNF-alpha Inhibitors: A Vital Tool for Rheumatoid Arthritis Management

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects millions of people worldwide. This study examines the use of enzyme-linked immunosorbent assays (ELISAs) for monitoring TNF-alpha inhibitors and antibody levels in patients with RA. The researchers investigated the role of ELISAs in informing treatment decisions and understanding the reasons for treatment non-response or loss of response.

ELISAs: A Precise Way to Monitor Treatment

ELISAs offer a precise way to measure drug and antibody levels in the blood. This information can be invaluable in guiding treatment decisions and adjusting therapy as needed. The study found that ELISAs can be used to assess the response to TNF-alpha inhibitors, identify the presence of anti-drug antibodies, and help explain why some patients may not respond to treatment or experience a loss of response over time.

Ensuring Effective Treatment for Rheumatoid Arthritis

This study emphasizes the importance of monitoring TNF-alpha inhibitor levels and antibody levels in patients with RA. By using ELISAs, doctors can gain valuable insights into the effectiveness of treatment and make informed adjustments to therapy as needed. This can help ensure that patients receive the most effective treatment for their condition.

Dr.Camel's Conclusion

Managing rheumatoid arthritis can be like navigating a shifting desert landscape. This study highlights the critical role of ELISAs in helping doctors chart a course for effective treatment. By carefully monitoring drug and antibody levels, we can optimize treatment strategies and provide patients with the best possible care.

Date :
  1. Date Completed 2021-10-25
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

33555998

DOI: Digital Object Identifier

PMC7898084

Related Literature

Article Analysis
・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

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