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Cancer-Targeted Controlled Delivery of Chemotherapeutic Anthracycline Derivatives Using Apoferritin Nanocage Carriers.

Author: HepelMaria, HerschkowitzJason I, KurzątkowskaKatarzyna, PazosManuel A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the interactions of anthracycline drugs with apoferritin (APO), a nanocage protein used in controlled drug delivery systems. The study found that the lipophilicity of anthracycline drugs impacted their encapsulation efficiency and in vitro activity. The encapsulated drugs showed high apoptotic activity against targeted cancer cells and low activity against healthy cells, demonstrating their targeting ability.
Paper Details　
Original Abstract of the Article :
The interactions of chemotherapeutic drugs with nanocage protein apoferritin (APO) are the key features in the effective encapsulation and release of highly toxic drugs in APO-based controlled drug delivery systems. The encapsulation enables mitigating the drugs' side effects, collateral damage to h...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866407/

データ提供：米国国立医学図書館（NLM）

A Trojan Horse for Cancer Treatment: Apoferritin Nanocages Deliver Chemotherapeutic Drugs

The battle against [cancer] is an ongoing struggle, and researchers are constantly seeking new and innovative ways to attack this formidable foe. This research delves into the world of [nanotechnology], exploring the use of [apoferritin nanocages] as intelligent delivery vehicles for [chemotherapeutic anthracycline derivatives]. By encapsulating these potent drugs within these nanocages, researchers aim to enhance their effectiveness while minimizing side effects.

Targeting Cancer Cells: Apoferritin Nanocages Deliver Chemotherapeutic Drugs with Precision

This study showcases the potential of [apoferritin nanocages] as a promising approach for delivering [chemotherapeutic drugs] to cancer cells with greater precision. The study's findings highlight the ability of these nanocages to encapsulate drugs, mitigating their side effects and enhancing their therapeutic efficacy. This targeted delivery approach could potentially revolutionize cancer treatment, offering patients more effective and less toxic therapies.

A New Frontier in Cancer Treatment: Apoferritin Nanocages Offer Hope

This research offers a glimpse into the exciting future of cancer treatment, where nanotechnology plays a central role. Apoferritin nanocages offer a promising approach for delivering chemotherapeutic drugs with greater precision, minimizing side effects and maximizing therapeutic efficacy. This innovation holds the potential to revolutionize cancer treatment, offering patients more effective and less toxic therapies.

Dr.Camel's Conclusion

This study demonstrates the potential of apoferritin nanocages as a powerful tool for delivering chemotherapeutic drugs with greater precision. This innovative approach could lead to more effective and less toxic cancer treatments, offering hope for patients battling this formidable disease.

Date :
  1. Date Completed 2021-09-07
  2. Date Revised 2021-09-07
Further Info :

Pubmed ID

33572999

DOI: Digital Object Identifier

PMC7866407

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Languages

English

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