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Triumeq Increases Excitability of Pyramidal Neurons in the Medial Prefrontal Cortex by Facilitating Voltage-Gated Ca<sup>2+</sup> Channel Function.

Author: Al-HarthiLena, ChenLihua, HuXiu-Ti

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of Triumeq, a combination antiretroviral therapy (cART) regimen, on pyramidal neurons in rat brain slices. The study found that both acute and chronic Triumeq treatment increased neuronal firing and calcium influx, suggesting that cART may contribute to HIV-associated neurocognitive disorders by inducing neuronal hyperexcitability.
Paper Details　
Original Abstract of the Article :
Combination antiretroviral therapy (cART) suppresses HIV-1 replication, improves immune function, and prolongs the life of people living with HIV (PLWH). However, cART also induces neurotoxicity that could complicate HIV-induced neurodegeneration while reduce its therapeutic efficacy in treating HIV...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876243/

データ提供：米国国立医学図書館（NLM）

Triumeq: Navigating the Desert of HIV Treatment

HIV treatment is a complex desert, with many challenges along the way. This study explores the impact of Triumeq, a first-line combination antiretroviral therapy (cART) regimen, on the brain. The researchers investigated the effects of Triumeq and its component drugs, lamivudine, abacavir, and dolutegravir, on pyramidal neurons in the medial prefrontal cortex (mPFC) of rat brain slices. Their findings reveal that Triumeq significantly increases the excitability of these neurons by enhancing calcium influx through voltage-gated calcium channels.

The Oasis of cART: Navigating Potential Neurotoxicity

This study underscores the potential for cART to influence neuronal activity in the brain. The researchers found that Triumeq, a common cART regimen, increases the excitability of pyramidal neurons in the mPFC, a brain region essential for cognitive function. This finding highlights the need for further research to understand the potential neurotoxic effects of cART and to develop strategies for mitigating these effects.

Navigating the Desert of HIV: Understanding the Brain's Impact

The study's findings emphasize the importance of understanding the potential impact of HIV treatment on the brain. It's crucial to engage with a healthcare professional to discuss the benefits and risks of cART and to monitor for any potential neurocognitive side effects. By working together, we can navigate the desert of HIV treatment with greater awareness and personalized care.

Dr.Camel's Conclusion

This research serves as a reminder that the desert of HIV treatment is constantly shifting, and we must remain vigilant in understanding the potential impact of treatments on the brain. The study's findings provide valuable insights into the complexities of cART and the need for continued research and personalized care.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-04-16
Further Info :

Pubmed ID

33584297

DOI: Digital Object Identifier

PMC7876243

SNS
PICO Info
in preparation
Languages

English

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