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Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis.

Author: GeShuai, HeHuaizhen, HeLangchong, HouYajing, LiXiaowei, WangCheng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Loratadine (LOR) and desloratadine (DES), histamine H1 antagonists, were found to inhibit SARS-CoV-2 spike pseudotyped virus entry into ACE2-overexpressing HEK293T cells, with DES showing greater effectiveness. Binding experiments revealed that both antagonists bind to ACE2, with DES exhibiting a stronger binding affinity than LOR. Molecular docking results suggested that both LOR and DES bind to ACE2 at the SARS-CoV-2 binding site interface.
Paper Details　
Original Abstract of the Article :
Currently, there is an urgent need to find a treatment for the highly infectious coronavirus disease (COVID-19). However, the development of a new, effective, and safe vaccine or drug often requires years and poses great risks. At this critical stage, there is an advantage in using existing clinical...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889471/

データ提供：米国国立医学図書館（NLM）

Loratadine and Desloratadine: Potential Weapons Against COVID-19?

This research delves into the exciting world of [virology] and [drug repurposing], exploring the possibility of using existing medications to combat the [COVID-19 pandemic]. The study found that loratadine and desloratadine, commonly used [antihistamines], can inhibit the entry of a [SARS-CoV-2 spike pseudotyped virus] into cells. Interestingly, desloratadine demonstrated a stronger inhibitory effect than loratadine. The study further revealed that both antihistamines can bind to [ACE2], the entry point for the virus, with desloratadine exhibiting stronger binding affinity.

Antihistamines: A New Frontier in Viral Defense?

This is a potential game changer in the fight against COVID-19. Imagine, a desert traveler finding a hidden oasis amidst scorching sands, providing much-needed relief. This research offers a similar promise of hope by potentially repurposing existing medications to combat the virus.

Implications for COVID-19 Treatment

These findings are very promising, but more research is needed before loratadine and desloratadine can be used to treat COVID-19. However, the potential of these antihistamines as a therapeutic option is definitely worth exploring.

Dr. Camel's Conclusion

This study showcases the exciting potential of drug repurposing in the fight against COVID-19. Loratadine and desloratadine may offer a new strategy for treating the virus. Just as camels have adapted to the harsh desert environment, researchers are constantly seeking ways to adapt existing resources to combat new challenges.

Date :
  1. Date Completed 2021-03-31
  2. Date Revised 2021-03-31
Further Info :

Pubmed ID

33609497

DOI: Digital Object Identifier

PMC7889471

Related Literature

Article Analysis
・Effects of desloratadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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