Guanabenz and methyldopa on hypertension and cardiac performance.

Author: HelfantR H, RamanathanK B, ShahR S, VanovS K, WalkerB R

Paper Details 
Original Abstract of the Article :
In previous placebo-controlled studies, guanabenz was shown to be a safe and effective antihypertensive drug without acute effects on cardiac function. In view of its therapeutic advantages, a double-blind comparison of guanabenz with methyldopa was performed in a group of 36 patients over 6 mo. Bot...See full text at original site
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引用元:
https://doi.org/10.1002/cpt1977226868

データ提供:米国国立医学図書館(NLM)

Guanabenz vs. Methyldopa: A Comparative Study in Hypertension Management

Hypertension, or high blood pressure, is a major health concern that affects millions of people worldwide. This research delves into the world of [cardiology], comparing the effectiveness and safety of two antihypertensive drugs, guanabenz and methyldopa. The authors conducted a double-blind study involving 36 patients over a 6-month period. Both drugs were found to effectively lower blood pressure, with similar side effect profiles. However, the study revealed that methyldopa was associated with a statistically significant increase in systolic time interval and the ratio of pre-ejection period to left ventricular ejection time, suggesting a potential impact on cardiac function.

Finding the Right Antihypertensive Medication

This study underscores the importance of considering the individual characteristics of each antihypertensive drug and its potential impact on cardiac function. While both guanabenz and methyldopa were effective in lowering blood pressure, the findings suggest that guanabenz may be a safer choice for patients who are concerned about potential effects on cardiac performance. This research emphasizes the need for personalized medicine approaches in hypertension management, taking into account individual patient needs and risk factors.

Managing Your Blood Pressure

If you have hypertension, it's important to work with your doctor to develop a personalized treatment plan that addresses your individual needs. There are many different antihypertensive medications available, and your doctor will help you choose the best option based on your medical history, lifestyle, and risk factors. Remember, managing your blood pressure is crucial for maintaining overall health and preventing serious complications.

Dr.Camel's Conclusion

This study provides valuable insights into the comparative effectiveness and safety of guanabenz and methyldopa in treating hypertension. It highlights the importance of considering the potential impact of antihypertensive medications on cardiac function, emphasizing the need for personalized medicine approaches in managing this common condition.

Date :
  1. Date Completed 1978-01-27
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

336257

DOI: Digital Object Identifier

10.1002/cpt1977226868

Related Literature

SNS
PICO Info
in preparation
Languages

English

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