Side Effects of guanabenz: A Synthesis of Findings from 33 Studies

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Original Abstract of the Article

Main Research Findings

Guanabenz is an α2-adrenergic receptor agonist that has been used to treat high blood pressure. Some studies have shown that guanabenz is effective in treating high blood pressure. 1 , 12 , 16 , 11 , 33 , 26 , 27 , 23 , 18 , 21 , 31 , 8 , 24 , 32 , 13 , 17 , 20 , 14 , 4 , 30 , 25 , 22 , 28 , 19 , 15 , 29 , 10

Reasons for Side Effects

Guanabenz works by affecting the α2-adrenergic receptors in the central nervous system, which reduces sympathetic nerve activity and lowers blood pressure. 8 This action works by suppressing sympathetic nerve activity in the central nervous system, which in turn inhibits the effects on the heart and blood vessels, thus lowering blood pressure. 8 This action plays an important role in regulating blood pressure, but it can also potentially affect various parts of the central nervous system, which may lead to side effects.

Common Side Effects

Drowsiness

The most common side effect of guanabenz is drowsiness. 12 , 6 , 11 , 26 , 31 , 8 , 20 , 29 , 10 This is caused by guanabenz acting on the central nervous system and suppressing sympathetic nerve activity.

Dry Mouth

Another common side effect of guanabenz is dry mouth. 12 , 11 , 26 , 31 , 8 , 30 , 25 , 29 , 10 This is caused by guanabenz suppressing saliva production.

Weakness

Guanabenz can cause weakness or fatigue. 26 , 29

Dizziness

Guanabenz can cause dizziness. 26 , 30 , 29

Gastrointestinal Symptoms

Guanabenz can cause gastrointestinal symptoms. 31 , 19 For example, nausea, vomiting, and abdominal pain may occur.

Cardiovascular Symptoms

Guanabenz may cause cardiovascular symptoms. 33 For example, changes in heart rate and decreased blood pressure may occur.

Others

Guanabenz can cause various side effects other than those mentioned above. 13 Specific side effects vary depending on the patient, so it is important to consult with a doctor.

Side Effects Countermeasures

Drowsiness

Drowsiness is the most common side effect of guanabenz. 12 Avoid driving or operating machinery while taking guanabenz. 12 Also, take a rest if you feel drowsy.

Dry Mouth

Dry mouth is another common side effect of guanabenz. 12 Make sure you drink enough water. 12 If your dry mouth is severe, consult your doctor.

Weakness

If you feel weak, take a rest. 26 If your weakness is severe, consult your doctor.

Dizziness

If you feel dizzy, get up slowly. 26 If your dizziness is severe, consult your doctor.

Gastrointestinal Symptoms

If you experience gastrointestinal symptoms, consult your doctor. 31 Dietary therapy and lifestyle changes may also be helpful.

Cardiovascular Symptoms

If you experience cardiovascular symptoms, consult your doctor immediately. 33

Others

If you have any concerns about the side effects of guanabenz, consult your doctor.

Comparison Between Studies

Similarities Between Studies

Many studies have shown that guanabenz is effective in treating high blood pressure. 1 , 12 , 16 , 11 , 33 , 26 , 27 , 23 , 18 , 21 , 31 , 8 , 24 , 32 , 13 , 17 , 20 , 14 , 4 , 30 , 25 , 22 , 28 , 19 , 15 , 29 , 10 Also, guanabenz has been reported to cause side effects such as drowsiness and dry mouth. 12 , 11 , 26 , 31 , 8 , 30 , 25 , 29 , 10

Differences Between Studies

There are differences in the effectiveness, frequency, and severity of side effects of guanabenz depending on the study. 12 , 1 , 25 This is thought to be due to differences in the patient population studied, the dosage of guanabenz, and the duration of the study. 12 , 1 , 25

Notes on Applying Research to Real Life

Guanabenz is an effective drug for treating high blood pressure, but it comes with the risk of side effects. 12 , 11 , 26 , 31 , 8 , 30 , 25 , 29 , 10 When taking guanabenz, follow your doctor's instructions and consult your doctor immediately if you experience any side effects.

Limitations of Current Research

There is still not enough research on the side effects of guanabenz. 12 , 1 , 25 In particular, long-term side effects are still not fully understood. 12 , 1 , 25 Also, not enough research has been done on how guanabenz affects various diseases and conditions. 12 , 1 , 25

Future Research Directions

Research on the long-term side effects of guanabenz and the effects it has on various diseases and conditions is needed. 12 , 1 , 25 Also, by studying the mechanism of action of guanabenz in more detail, it may be possible to reduce side effects. 12 , 1 , 25

Conclusion

Guanabenz is an effective drug for treating high blood pressure, but it comes with the risk of side effects. 12 , 11 , 26 , 31 , 8 , 30 , 25 , 29 , 10 When taking guanabenz, follow your doctor's instructions and consult your doctor immediately if you experience any side effects.

Keywords
Benefit Keywords
Reduces neuronal death
1
Therapeutic development
2
Blood pressure reduction
Metabolic improvement
3
Analgesia sparing
Anesthesia sparing
Hypertension treatment
4
Neuropathic pain relief
6
Reduced blood pressure
Selective I1-receptor agonists
7
Lower blood pressure
8
Blood pressure control
9
Blood pressure control
No severe side effects
10
Hypertension treatment
Lipid safety
11
Lower blood pressure
Well tolerated
12
Effective treatment
Well tolerated
13
Effective for heroin addiction
14
Blood pressure reduction
15
Blood pressure reduction
Cholesterol reduction
16
Blood pressure reduction
17
Hypertension treatment
18
Opioid withdrawal suppression
19
Blood pressure reduction
Lowered cholesterol
20
Blood pressure reduction
No effect on diabetes
21
Blood pressure reduction
Improved sodium excretion
22
Lowered blood pressure
23
Natriuretic properties
Potential for treating hypertension
24
Treats hypertension
25
Enhances diuretic efficacy
Treats hypertension
26
Blood pressure control
Effective antihypertensive
27
Lowers blood pressure
Treats hypertension
28
Effective antihypertensive
Well-tolerated
29
Reduced blood pressure
30
Blood pressure control
31
Blood pressure reduction
32
Effective antihypertensive
No acute cardiac effects
Paucity of side effects
Safe antihypertensive
33
Risk Keywords
Drug-related side effects
1
Salt and water retention
4
Memory impairment
5
Hyperactivity
6
Drowsiness
Sedation
8
Reduced efficacy in long term patients
10
Drowsiness
Dry mouth
12
Side effects
15
Edema
Tolerance
Weight gain
17
Cardiac arrhythmias
Drug sensitivity increase
Left ventricular dysfunction
18
Side effects
19
Side effects
20
Edema
Sodium retention
22
Drowsiness
Dry mouth
23
Sodium retaining side effects
24
Drowsiness
Dry mouth
25
Dizziness
Drowsiness
Dry mouth
Weakness
26
Dizziness
Drowsiness
Dry mouth
27
Dry mouth
Sedation
28
Dry mouth
Sedation
29
Dry mouth
Sedation
30
Depression
Dry mouth
Nausea
Urticaria
31
Drowsiness
Dry mouth
32
Positive Coombs' tests
33
Literature analysis of 33 papers
Positive Content
32
Neutral Content
0
Negative Content
1
Article Type
7
0
0
6
33
1.

The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial.

Author: Dalla BellaEleonora, BersanoEnrica, AntoniniGiovanni, BorgheroGiuseppe, CapassoMargherita, CaponnettoClaudia, ChiòAdriano, CorboMassimo, FilostoMassimiliano, GianniniFabio, SpataroRossella, LunettaChristian, MandrioliJessica, MessinaSonia, MonsurròMaria Rosaria, MoraGabriele, RivaNilo, RizziRomana, SicilianoGabriele, SilaniVincenzo, SimoneIsabella, SorarùGianni, TugnoliValeria, VerrielloLorenzo, VolantiPaolo, FurlanRoberto, NolanJohn M, AbgueguenEmmanuelle, TramacereIrene, LauriaGiuseppe

Reduces neuronal death
Drug-related side effects

This study investigated the safety and efficacy of guanabenz, an endoplasmic reticulum stress inhibitor, in patients with amyotrophic lateral sclerosis (ALS). The results suggest that guanabenz may slow disease progression, particularly in patients with bulbar onset, but with potential side effects.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype.

Author: GaleottiNicoletta, BartoliniAlessandro, GhelardiniCarla

Memory impairment

Clonidine and guanabenz, alpha2-adrenergic agonists, have been shown to impair memory function in rats and humans. This study found that these drugs induced amnesia in mice through the selective activation of the alpha2A-adrenoceptor subtype. The amnesia was preventable by pretreatment with alpha2-antagonists.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats.

Author: Jevtovic-TodorovicV, MeyenburgA P, OlneyJ W, WozniakD F

Neuropathic pain relief
Hyperactivity

Procyclidine and ethopropazine, when combined with an alpha(2) adrenergic agonist, effectively and long-lastingly relieved neuropathic pain in rats without neurotoxic side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Central imidazoline (I1) receptors as targets of centrally acting antihypertensives: moxonidine and rilmenidine.

Author: van ZwietenP A

Reduced blood pressure
Selective I1-receptor agonists

Moxonidine and rilmenidine, selective I1-receptor agonists, offer potential for antihypertensive therapy with fewer side effects than alpha2-receptor agonists.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

[Centrally acting sympathetic inhibitors for therapy of patients with hypertension].

Author: KawasakiH

Lower blood pressure
Drowsiness
Sedation

Centrally acting antihypertensive drugs, like clonidine, effectively lower blood pressure by acting as alpha 2-adrenoceptor agonists in the brain. Newer imidazoline compounds, like rilmenidine and moxonidine, may offer a similar benefit without sedation and drowsiness.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

9.

Why imidazoline receptor modulator in the treatment of hypertension?

Author: SchäferS G, KaanE C, ChristenM O, Löw-KrögerA, MestH J, MolderingsG J

Blood pressure control

Moxonidine, a second-generation centrally acting antihypertensive drug, selectively targets I1-imidazoline receptors, leading to blood pressure lowering with fewer side effects than first-generation drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

[Clinical and fundamental study of guanabenz in hypertensive patients with renal failure].

Author: NishioS, HayashiS, YoshiharaH

Blood pressure control
No severe side effects
Reduced efficacy in long term patients

Guanabenz was effective in controlling hypertension in 65% of hemodialysis patients, with 90% achieving fair control. The drug's efficacy was higher in patients with shorter hemodialysis duration. Guanabenz was well-tolerated with no serious side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

11.

Guanfacine as monotherapy for systemic hypertension.

Author: FillingimJ M, BlackshearJ L, StraussA, StraussM

Hypertension treatment
Lipid safety

Guanfacine monotherapy was studied in three clinical trials of patients with mild essential hypertension. Guanfacine was found to be effective in lowering diastolic blood pressure without affecting plasma volume, plasma aldosterone, or serum lipids. No significant side effects were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Treatment of hypertension in the elderly.

Author: WeberM A, DrayerJ I

Lower blood pressure
Well tolerated
Drowsiness
Dry mouth

Guanabenz, a centrally acting antihypertensive agent, was effective in treating predominant systolic hypertension in elderly patients. Both guanabenz alone and in combination with hydrochlorothiazide significantly decreased systolic and diastolic blood pressures, with no evidence of orthostatic effects. The most common side effects were drowsiness and dry mouth.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Guanabenz therapy for opiate withdrawal.

Author: MulryJ T

Effective treatment
Well tolerated

Guanabenz, a clonidine-like alpha 2 agonist, effectively relieved opiate withdrawal symptoms in a patient who experienced dose-related clonidine side effects. Guanabenz shows promise as an opiate withdrawal agent, as it may provide a safer alternative to clonidine.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

[Use of presynaptic alpha-mimetics for withdrawal in heroin addicts].

Author: GorceixA, DugarinJ, PommierF

Effective for heroin addiction

Guanoxabenz and Guanfacine, presynaptic alpha-mimetic drugs, were used in the treatment of heroin addicts.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

18.

Treatment of the elderly hypertensive patient.

Author: ChobanianA V

Hypertension treatment
Cardiac arrhythmias
Drug sensitivity increase
Left ventricular dysfunction

Aging can lead to hypertension and its complications. Diuretics, beta blockers, and calcium channel blockers are effective treatments for hypertension in the elderly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Guanabenz acetate: a new, long-acting alpha-two adrenergic agonist for opioid withdrawal.

Author: TennantF S, RawsonR A

Opioid withdrawal suppression
Side effects

Guanabenz acetate effectively suppressed opioid withdrawal in 47 subjects, with fewer side effects than clonidine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Step-one antihypertensive therapy: a comparison of a centrally acting agent and a diuretic.

Author: McCarronD A

Blood pressure reduction
Lowered cholesterol
Side effects

Guanabenz and hydrochlorothiazide (HCTZ) both lowered blood pressure in 147 patients, but guanabenz had fewer side effects and a more favorable effect on serum cholesterol. HCTZ caused electrolyte and metabolic disturbances.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Natriuretic and water diuretic effects of central alpha 2-adrenoceptor agonists.

Author: GehrM, MacCarthyE P, GoldbergM

Blood pressure reduction
Improved sodium excretion
Edema
Sodium retention

Guanabenz, a centrally acting antihypertensive, may have a more favorable effect on sodium balance than other centrally acting agents. It may be useful for patients who develop edema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

24.

Natriuretic and water diuretic effects of guanabenz, a central alpha-2 agonist.

Author: GoldbergM, GehrM, MacCarthyE P

Natriuretic properties
Potential for treating hypertension
Sodium retaining side effects

Guanabenz, an antihypertensive drug, has natriuretic properties and may be a useful therapeutic agent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

25.

Guanabenz versus methyldopa in the therapy of mild-to-moderate hypertension.

Author: RosendorffC

Treats hypertension
Drowsiness
Dry mouth

Guanabenz and methyldopa were found to be equally effective in treating mild-to-moderate essential hypertension in 30 patients. However, guanabenz was associated with a significantly greater incidence of side effects, particularly dry mouth.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Evaluation of guanabenz added to hydrochlorothiazide therapy in hypertension.

Author: WalkerB R, DeitchM W, GoldJ A, LeveyB A

Enhances diuretic efficacy
Treats hypertension
Dizziness
Drowsiness
Dry mouth
Weakness

Guanabenz, a centrally acting alpha-adrenergic antihypertensive agent, was found to enhance the antihypertensive efficacy of hydrochlorothiazide in 204 hypertensive patients. The addition of guanabenz resulted in a significant decrease in blood pressure and an increase in the response rate without compromising the diuretic effects of hydrochlorothiazide. However, the combination therapy was associated with a greater incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Effect of guanabenz and hydrochlorothiazide on blood pressure and plasma renin activity.

Author: HollandO B, FairchildC, Gomez-SanchezC E

Blood pressure control
Effective antihypertensive
Dizziness
Drowsiness
Dry mouth

Guanabenz, a new antihypertensive drug, was found to be more effective when used with a diuretic.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

28.

Long-term therapy of hypertension with guanabenz.

Author: WalkerB R, DeitchM W, SchneiderB E, HareL E, GoldJ A

Lowers blood pressure
Treats hypertension
Dry mouth
Sedation

Guanabenz, a centrally acting antihypertensive, was safe and effective in treating hypertension. It reduced blood pressure and had minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

29.

Effects of placebo versus guanabenz on hypertensive out-patients.

Author: WalkerB R, SchneiderB E, RudnickM R, GoldJ A

Effective antihypertensive
Well-tolerated
Dry mouth
Sedation

Guanabenz acetate was effective in treating hypertension in outpatients. 70% of guanabenz-treated patients experienced a clinically significant decrease in blood pressure, compared with 41% of placebo-treated patients. The most common side effects were sedation and dry mouth.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Comparison of guanabenz and clonidine in hypertensive patients.

Author: KluyskensY, SnoeckJ

Reduced blood pressure
Dry mouth
Sedation

Guanabenz and clonidine are both effective in reducing blood pressure. The most common side effects are dry mouth and sedation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Preliminary clinical trial with a new hypotensive, guanabenz, in a group of hypertensive patients.

Author: De RidderJ H, MarchandiseP

Blood pressure control
Depression
Dry mouth
Nausea
Urticaria

Guanabenz is effective in controlling blood pressure in 64% of hypertensive patients. The most common side effects are dry mouth and nausea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

32.

Evaluation of the efficacy and safety of guanabenz versus clonidine.

Author: LearyW P, AsmalA C, WilliamsP C

Blood pressure reduction
Drowsiness
Dry mouth

Guanabenz and clonidine were both effective in reducing blood pressure in patients with uncomplicated essential hypertension. Both drugs had similar side effects, such as dry mouth and drowsiness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Guanabenz and methyldopa on hypertension and cardiac performance.

Author: WalkerB R, ShahR S, RamanathanK B, VanovS K, HelfantR H

Effective antihypertensive
No acute cardiac effects
Paucity of side effects
Safe antihypertensive
Positive Coombs' tests

Guanabenz was found to be as effective as methyldopa in reducing blood pressure, with similar side effects. Guanabenz had no adverse cardiac effects and showed a paucity of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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