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Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ.

Author: JiangLingyun, KangLin, LiangZhen, MaChuanrui, TaoXiuhua, WeiLingling, WuHan, XiangJiaqing, YangGuangyan, YangShu, ZhangWei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tectorigenin is a compound that activates the peroxisome proliferator-activated receptor gamma (PPARγ) in the liver. PPARγ activation is associated with improvements in liver health. This study investigated the effects of tectorigenin in mice with cholestasis, a condition that occurs when bile flow from the liver is blocked.
Paper Details　
Original Abstract of the Article :
Increasing evidence suggests that human cholestasis is closely associated with the accumulation and activation of hepatic macrophages. Research indicates that activation of PPARγ exerts liver protective effects in cholestatic liver disease (CLD), particularly by ameliorating inflammation and fibrosi...See full text at original site
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引用元：
https://doi.org/10.1111/bph.15429

データ提供：米国国立医学図書館（NLM）

Tectorigenin: A Natural Compound for Intrahepatic Cholestasis

Intrahepatic cholestasis, a condition characterized by [bile accumulation in the liver], can lead to [liver damage and inflammation]. While existing treatments for cholestasis have limitations, natural compounds are being investigated for their potential therapeutic benefits. This study explores the effects of [tectorigenin], a natural compound found in plants, on intrahepatic cholestasis in mice.

Tectorigenin's Promise: Combating Cholestasis Through PPARγ Activation

The study found that tectorigenin alleviated intrahepatic cholestasis in mice by [activating PPARγ], a nuclear receptor involved in regulating [inflammation, lipid metabolism, and bile acid homeostasis]. Tectorigenin demonstrated its effectiveness by reducing [liver inflammation] and [bile accumulation], offering a potential new treatment strategy for cholestatic liver disease.

Harnessing Nature's Power: Exploring Natural Compounds for Liver Health

This study highlights the exciting potential of tectorigenin as a natural therapeutic agent for intrahepatic cholestasis. The research encourages further investigation of natural compounds for treating liver diseases, emphasizing the importance of exploring alternative approaches to address unmet medical needs. As a wise camel, I always emphasize the importance of looking beyond traditional treatments and exploring the vast potential of natural remedies to address health challenges.

Dr. Camel's Conclusion

This study uncovers the promising potential of tectorigenin for combating intrahepatic cholestasis. The research highlights the importance of exploring natural compounds for liver health and encourages further investigation into their therapeutic applications. It's a reminder that nature holds a wealth of potential solutions for addressing health challenges, and we should continue to explore these natural resources for the benefit of human health.

Date :
  1. Date Completed 2021-07-05
  2. Date Revised 2021-07-05
Further Info :

Pubmed ID

33661551

DOI: Digital Object Identifier

10.1111/bph.15429

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Languages

English

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