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Next generation live-attenuated yellow fever vaccine candidate: Safety and immuno-efficacy in small animal models.

Author: GautheronSylviane, Girerd-ChambazYves, MantelNathalie, Piras-DouceFabienne, RaquinAlix, RaynalFranck, SanchezMartha Erika Navarro, VangelistiManuel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study describes the generation and selection of a live-attenuated yellow fever (YF)-17D vaccine candidate (vYF-247). Preclinical data suggests that vYF-247, derived from the YF-VAX lineage, could provide robust protection against YF disease in humans, similar to currently marketed YF vaccines.
Paper Details　
Original Abstract of the Article :
Yellow fever (YF) remains a threat to human health in tropical regions of Africa and South America. Live-attenuated YF-17D vaccines have proven to be safe and effective in protecting travellers and populations in endemic regions against YF, despite very rare severe reactions following vaccination - ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047865/

データ提供：米国国立医学図書館（NLM）

Next-Generation Yellow Fever Vaccine Candidate: A Safer and More Effective Solution

This study explores the realm of [vaccination] and presents a promising new candidate for a live-attenuated yellow fever (YF) vaccine. The researchers focused on [generating and selecting a safer and more effective YF vaccine candidate] by creating a series of sub-strains of the YF-17D vaccine. They carefully evaluated these sub-strains in animal models to assess their safety, immunogenicity, and efficacy. The study identified a vaccine candidate, vYF-247, that demonstrated a superior safety profile compared to existing YF vaccines, while retaining strong immunogenicity and protective efficacy against YF disease.

A Safer Path to Yellow Fever Protection

This research offers a significant advancement in the fight against YF disease, offering a potentially safer and more effective vaccine candidate for both travelers and residents of endemic regions. The findings provide hope for reducing the risk of vaccine-associated adverse events and increasing the effectiveness of YF vaccination.

Protecting Against Yellow Fever: A Global Effort

This study highlights the ongoing quest for safer and more effective vaccines to protect populations worldwide from infectious diseases. Imagine a future where vaccines, like beacons of light in the vast desert, guide us towards a healthier world, free from the threat of devastating diseases.

Dr.Camel's Conclusion

This research is like a camel caravan carrying a precious cargo of hope across the desert of infectious diseases. By developing safer and more effective vaccines, scientists are paving the way for a healthier future, where vaccines act as shields against the dangers lurking in the world.
Date :
  1. Date Completed 2021-05-24
  2. Date Revised 2021-05-24
Further Info :

Pubmed ID

33685778

DOI: Digital Object Identifier

PMC8047865

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・Effects of yellow fever vaccine
SNS
PICO Info
in preparation
Languages

English

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