[Neurophysiological and therapeutic evaluation of stiripentol in epilepsy. Preliminary results].

Author: DodrillC, LevyR H, LoiseauP, StrubeE, TorJ

Paper Details 
Original Abstract of the Article :
The main objective of this study was to determine whether stripentol (STP) alleviates side-effects commonly observed in treated epileptic patients, since preliminary data suggested a positive psychotropic effect. A secondary objective was an evaluation of drug efficacy. Eleven patients with either a...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/3368691

データ提供:米国国立医学図書館(NLM)

Stiripentol: A Potential Treatment for Epilepsy with Potential Psychotropic Benefits

Epilepsy is a neurological disorder that affects millions worldwide, a complex condition that can significantly impact a person's life. This research investigates the potential of stiripentol (STP), an anticonvulsant drug, as a treatment for epilepsy. The authors focus on evaluating STP's efficacy in reducing seizures and alleviating side effects commonly observed in epileptic patients.

Stiripentol's Promise: A Potential Solution for Challenging Epilepsy Cases

The study included 11 patients with drug-resistant epilepsy or toxic effects from antiepileptic drugs (AEDs). STP was added to their baseline therapy, and the dose of existing AEDs was reduced to maintain stable plasma levels. The researchers observed a trend of improvement in attention tasks and a decrease in drowsiness in several patients. Importantly, six out of nine uncontrolled patients experienced a reduction in seizure frequency of at least 50%.

Expanding Treatment Options for Epilepsy: A Pathway to Improved Care

This study suggests that stiripentol holds promise as a potential treatment option for epilepsy, especially for those with drug-resistant forms or who experience adverse effects from other AEDs. The results warrant further investigation through larger clinical trials to confirm its efficacy and safety in a wider patient population.

Dr.Camel's Conclusion

Navigating the desert of epilepsy treatment can be a challenging experience. This study offers a glimmer of hope, showcasing the potential of stiripentol as a promising treatment option. While more research is needed, the findings suggest that stiripentol could provide relief for those struggling with this complex condition, paving the way for improved quality of life and greater control over their seizures.

Date :
  1. Date Completed 1988-06-21
  2. Date Revised 2012-11-15
Further Info :

Pubmed ID

3368691

DOI: Digital Object Identifier

3368691

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SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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