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Prostaglandin-induced diarrhoea treated with loperamide or diphenoxylate. A double-blind study.

Author: AmeryW, LangeA P, SecherN J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Loperamide was more effective than diphenoxylate and placebo in preventing diarrhea in women receiving prostaglandin for mid-trimester abortion. Both antidiarrhoeals were well-tolerated.
Paper Details　
Original Abstract of the Article :
Loperamide was compared double-blind with diphenoxylate and a placebo in 59 women with diarrhoea due to prostaglandin administration for mid-trimester abortion. Treatment was started with the intake of two capsules two hours before the first intramuscular injection of 15(S-)15 methyl prostaglandin F...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1111/j.0954-6820.1977.tb16863.x

データ提供：米国国立医学図書館（NLM）

Prostaglandin-Induced Diarrhea: A Desert Storm of Gut Discomfort

The realm of medicine is often a vast desert, where we encounter various challenges and seek solutions for a multitude of ailments. This study delves into the unwelcome territory of prostaglandin-induced diarrhea, a common side effect associated with prostaglandin administration for mid-trimester abortion. The researchers investigate the effectiveness of two antidiarrheal medications, loperamide and diphenoxylate, in managing this distressing condition.

A Oasis of Relief: Finding Effective Solutions for Diarrhea

The study demonstrates the efficacy of both loperamide and diphenoxylate in preventing and alleviating prostaglandin-induced diarrhea, compared to a placebo. The researchers observed that loperamide was more potent than diphenoxylate, providing further insight into the relative effectiveness of these antidiarrheal agents. These findings offer valuable guidance for clinicians seeking to manage this common side effect.

Navigating the Desert: Managing Diarrhea with Care

The study highlights the importance of managing prostaglandin-induced diarrhea, a common and often distressing side effect. The researchers' findings provide valuable information for healthcare professionals, enabling them to select the most appropriate antidiarrheal treatment for their patients and minimize the discomfort associated with this condition. This research underscores the ongoing commitment to improving patient care and alleviating the burden of side effects.

Dr. Camel's Conclusion

This study provides a valuable roadmap for navigating the desert storm of prostaglandin-induced diarrhea, highlighting the effectiveness of loperamide and diphenoxylate in managing this common side effect. The findings empower healthcare professionals to make informed decisions regarding antidiarrheal treatment, ensuring better outcomes and a more comfortable experience for their patients.

Date :
  1. Date Completed 1978-02-18
  2. Date Revised 2019-08-12
Further Info :

Pubmed ID

339672

DOI: Digital Object Identifier

10.1111/j.0954-6820.1977.tb16863.x

Related Literature

Article Analysis
・Side Effects of diphenoxylate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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