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Evidence that mCPP may have behavioural effects mediated by central 5-HT1C receptors.

Author: CurzonG, KennettG A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that the drug mCPP caused hypoactivity in rats and that this effect was reversed by antagonists that bind to 5-HT1C receptors. This suggests that mCPP is an agonist of 5-HT1C receptors. The study also found that antagonists of 5-HT1C receptors increased feeding in rats. This suggests that 5-HT1C receptors may play a role in the control of appetite.
Paper Details　
Original Abstract of the Article :
1. The effects of 1-(3-chlorophenyl)piperazine (mCPP) and 1-[3-(trifluoromethyl)phenyl] piperazine (TFMPP) on activity of rats in a novel cage, and on the rotorod and elevated bar co-ordination tests was examined. 2. Peripherally administered mCPP and TFMPP dose-dependently reduced locomotion, reari...See full text at original site
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引用元：
https://doi.org/10.1111/j.1476-5381.1988.tb11508.x

データ提供：米国国立医学図書館（NLM）

Unveiling the Secrets of 5-HT1C Receptors: A Journey into the Brain

The brain is a complex and fascinating landscape. Understanding how it works is like exploring a vast desert, filled with hidden pathways and secrets waiting to be discovered. This study investigates the role of a specific type of receptor in the brain, the 5-HT1C receptor, in response to certain chemicals. The authors examined the effects of two chemicals, mCPP and TFMPP, on rat behavior, focusing on their influence on activity, coordination, and appetite. Think of this study as a map guiding us through this complex brain region, unveiling how these chemicals interact with specific receptors.

5-HT1C Receptors: A Key to Understanding Behavior

This study suggests that the 5-HT1C receptor plays a significant role in regulating behavior, particularly in areas related to activity, coordination, and appetite. The findings demonstrate that mCPP, in particular, acts as an agonist of the 5-HT1C receptor, meaning it activates this receptor. This activation has profound effects on the behavior of the rats in the study. These findings provide valuable insights into the complex interplay between brain chemistry, receptors, and behavior.

Navigating the Desert of Brain Chemistry: Implications for Health

The research highlights the potential of targeting the 5-HT1C receptor for therapeutic purposes, particularly in areas related to appetite control and certain mental health conditions. It also underscores the need for further research to understand the full implications of 5-HT1C receptor activity in the brain. This journey into the brain's hidden depths is still ongoing, and each discovery offers a new perspective on the intricate network of chemical messengers that govern our behavior.

Dr. Camel's Conclusion

This study provides a fascinating glimpse into the intricate workings of the brain, specifically the role of the 5-HT1C receptor in regulating behavior. The findings suggest potential therapeutic applications for targeting this receptor, particularly in the areas of appetite control and mental health. This study serves as a reminder of the vast and complex landscape of the brain, with endless possibilities for discovery.

Date :
  1. Date Completed 1988-09-12
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

3401632

DOI: Digital Object Identifier

10.1111/j.1476-5381.1988.tb11508.x

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