Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review.

Author: BeijnenJos H, DorloThomas P C, HuitemaAlwin D R, VerrestLuka, WilthagenErica A

Paper Details 
Original Abstract of the Article :
BACKGROUND: Patients affected by poverty-related infectious diseases (PRDs) are disproportionally affected by malnutrition. To optimize treatment of patients affected by PRDs, we aimed to assess the influence of malnutrition associated with PRDs on drug pharmacokinetics, by way of a systematic revie...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545752/

データ提供:米国国立医学図書館(NLM)

Malnutrition's Impact on Drug Pharmacokinetics: A Critical Consideration for Poverty-Related Diseases

Poverty-related infectious diseases (PRDs) are a global challenge, often compounded by the devastating effects of malnutrition. This systematic review focuses on the influence of malnutrition on the pharmacokinetics of drugs used to treat PRDs, including HIV, tuberculosis, malaria, and neglected tropical diseases. The researchers are essentially investigating how malnutrition alters the way these drugs are absorbed, distributed, metabolized, and eliminated, ultimately influencing their effectiveness. This research, like a desert oasis providing essential resources, aims to optimize drug therapy in the face of malnutrition.

Navigating the Complexities of Malnutrition and Drug Therapy: A Guide for Effective Treatment

The systematic review, like a comprehensive desert map, reveals a complex and often unpredictable relationship between malnutrition and drug pharmacokinetics. The researchers found that malnutrition significantly affects the pharmacokinetics of many drugs used to treat PRDs, often reducing their effectiveness. This highlights the need for careful consideration of nutritional status in treating patients with PRDs, emphasizing the importance of tailored treatment approaches to optimize drug efficacy.

Understanding the Impact of Malnutrition: A Crucial Step in Global Health

Malnutrition, like a persistent desert drought, can have a devastating impact on health, particularly in the context of PRDs. This research underscores the importance of understanding the interplay between malnutrition and drug pharmacokinetics. By addressing nutritional deficiencies, like providing a vital source of water in a drought-stricken desert, we can improve the effectiveness of drug therapy and enhance the well-being of individuals suffering from PRDs.

Dr.Camel's Conclusion

This systematic review, like a wise desert elder sharing vital knowledge, highlights the critical influence of malnutrition on drug pharmacokinetics in the context of PRDs. Understanding these complex interactions, like navigating a treacherous desert landscape, is essential for optimizing treatment and improving the lives of those affected by these devastating diseases.

Date :
  1. Date Completed 2021-10-28
  2. Date Revised 2022-09-07
Further Info :

Pubmed ID

34060020

DOI: Digital Object Identifier

PMC8545752

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Languages

English

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