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Patient with Lobular Carcinoma of the Breast and Activating AKT1 E17K Variant.

Author: AlexanderBrian, FoxMarshall, FrigaultMatthew J, HamdaniOmar, MadiganAudrey, RaskinaKira, RichardJames, ShahKunal, SrkalovicGordan, ThomasBrittani, TrivediHarsha, WanderSeth, ZhangLiang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Precision medicine tools, such as molecular tumor boards and real-world data sets, can provide more treatment options for patients with metastatic breast cancer.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To present the characteristics of the AKT1E117K gene variant and a description of the clinical application in a patient with metastatic breast cancer. RESULTS: 63 y/o woman with Stage IV Invasive lobular carcinoma at diagnosis was treated with Palbociclib and aromatase inhibitors (AI). A...See full text at original site
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引用元：
https://doi.org/10.5644/ama2006-124.336

データ提供：米国国立医学図書館（NLM）

A Personalized Approach to Treating Metastatic Breast Cancer

This research delves into the complex world of breast cancer treatment, focusing on the use of precision medicine. The study employs a comprehensive genomic profiling approach, uncovering a specific genetic mutation - AKT1E17K - in a patient with metastatic breast cancer. This approach, much like a skilled detective piecing together clues, helps identify the best course of treatment tailored to the individual patient.

AKT1E17K Mutation: A Potential Target for Treatment

The study reveals that the presence of the AKT1E17K mutation in a patient with metastatic breast cancer can be a valuable guide for treatment decisions. This discovery, like finding a hidden oasis in the desert, suggests new avenues for effective therapies. The patient in the study responded positively to a combination of everolimus, an mTOR inhibitor, and an aromatase inhibitor, highlighting the potential of targeted therapies for this specific mutation.

Precision Medicine: A Path to Personalized Cancer Care

The use of precision medicine tools such as molecular tumor boards and real-world data sets is a game-changer in the fight against cancer. Imagine a vast desert landscape where each sand dune represents a unique cancer case. Precision medicine acts as a compass, guiding doctors through this landscape, pinpointing the most effective treatment for each individual patient.

Dr. Camel's Conclusion

This study beautifully illustrates the power of precision medicine in tailoring treatment approaches to individual patients. By focusing on the specific molecular characteristics of each cancer, we can unlock new possibilities for effective and personalized therapies, making the fight against breast cancer a bit less daunting.
Date :
  1. Date Completed 2021-10-25
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34075774

DOI: Digital Object Identifier

10.5644/ama2006-124.336

Related Literature

Article Analysis
・Side Effects of everolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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