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A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.

Author: BanconeGermana, CarraraVerena I, ChuCindy, DuanguppamaJureeporn, GilderMary Ellen, HaohankhunnathamWarat, ImwongMallika, KonghahongKamonchanok, LeeSue J, McGreadyRose, MinAung Myat, NostenFrançois, PawMoo Kho, PhyoAung Pyae, PimanpanarakMupawjay, ProuxStephane, SaitoMakoto, SinghasivanonPratap, TunNay Win, TurnerClaudia, Viladpai-NguenJacher, WhiteNicholas J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Malaria, a life-threatening disease, is becoming increasingly difficult to treat due to drug resistance. This review discusses the challenges posed by drug resistance in the Greater Mekong Subregion, particularly in pregnant women. The review highlights the need for effective treatments, especially for pregnant women, and emphasizes the importance of further research into artemisinin-based combination therapies for Plasmodium vivax malaria.
Paper Details　
Original Abstract of the Article :
Artemisinin and artemisinin-based combination therapy (ACT) partner drug resistance in Plasmodium falciparum have spread across the Greater Mekong Subregion compromising antimalarial treatment. The current 3-day artemether-lumefantrine regimen has been associated with high treatment failure rates in...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191049/

データ提供：米国国立医学図書館（NLM）

Malaria in Pregnancy: A Battle Against Drug Resistance in the Mekong

The battle against malaria, like navigating the ever-shifting sands of the Mekong Delta, requires vigilance and adaptability. This research delves into the complex world of malaria treatment, focusing on the challenges of drug resistance in pregnant women. The study explores the effectiveness of various artemisinin-based combination therapies (ACTs) against Plasmodium falciparum, a particularly troublesome type of malaria parasite. The research team conducted a randomized controlled trial to assess the efficacy of different ACT regimens, including dihydroartemisinin-piperaquine, artesunate-mefloquine, and extended artemether-lumefantrine.

The Evolving Landscape of Malaria Treatment

The study revealed that the current 3-day artemether-lumefantrine regimen, once a reliable beacon in the desert of malaria treatment, has exhibited high treatment failure rates in pregnant women. This underscores the urgent need for new and effective treatment strategies to address the evolving landscape of drug resistance. The research team's findings provide valuable insights into the challenges of treating malaria in pregnancy and highlight the importance of ongoing research and development of novel therapies.

Navigating the Desert of Drug Resistance

The study suggests that navigating the desert of drug resistance requires a multi-pronged approach. This includes ongoing research to develop new drugs and therapies, improved surveillance to monitor drug resistance patterns, and effective public health strategies to prevent malaria transmission. By working together, we can create a more stable and sustainable oasis in the fight against malaria.

Dr.Camel's Conclusion

The fight against malaria requires constant adaptation, like navigating the shifting sands of the Mekong Delta. The rise of drug resistance poses a formidable challenge, but with continued research and a collaborative approach, we can build a more resilient oasis in the fight against this ancient disease. By understanding the ever-evolving landscape of malaria, we can better protect pregnant women and their children from its devastating effects.

Date :
  1. Date Completed 2021-10-15
  2. Date Revised 2023-08-16
Further Info :

Pubmed ID

34107963

DOI: Digital Object Identifier

PMC8191049

Related Literature

Article Analysis
・Effects of artemether and lumefantrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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