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Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies.

Author: AcostaEdward, AgaEvgenia, AnanworanichJintanat, BarrLiz, BoschRonald J, CoombsRobert, DeeksSteven, FoxLawrence, GandhiRajesh T, KeeferMichael, KroonEugène, LandayAlan L, LiJonathan Z, MacLarenLynsay, MacatangayBernard, MellorsJohn W, PilkintonMark, SmithDavey M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

A study of 45 participants who interrupted antiretroviral therapy (ART) after achieving viral suppression found that early ART initiation, regardless of the ART regimen used (older or newer), was associated with a significant delay in time to HIV rebound. This suggests that early ART initiation lowers the barrier for HIV remission.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Development of human immunodeficiency virus (HIV) remission strategies requires precise information on time to HIV rebound after treatment interruption, but there is uncertainty regarding whether modern antiretroviral therapy (ART) regimens and timing of ART initiation may affect this ou...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906742/

データ提供：米国国立医学図書館（NLM）

A New Horizon for HIV Remission: Investigating Time to Viral Rebound

The development of HIV remission strategies is a significant goal in the fight against HIV infection. This study delves into the complex world of HIV viral rebound, investigating the time to viral rebound after treatment interruption. The researchers carefully monitored participants who interrupted their antiretroviral therapy (ART), much like a camel navigating the shifting sands of the desert, seeking to understand the factors influencing viral rebound. Their findings provide valuable insights into the potential for HIV remission and the influence of factors like timing of ART initiation and regimen choice.

A Shifting Landscape: Factors Influencing Time to Viral Rebound

The study's findings suggest that early ART initiation, regardless of the specific regimen used, can significantly delay time to viral rebound after treatment interruption. This observation, much like a camel navigating a treacherous desert path, highlights the importance of timing and treatment approaches in managing HIV infection. The findings provide a glimmer of hope for achieving HIV remission and underscore the need to continue exploring new strategies for managing this complex disease.

Navigating the Desert of HIV: Towards a Horizon of Remission

The study's findings underscore the importance of early ART initiation in managing HIV infection. This approach, like a camel seeking a distant oasis, provides a pathway towards achieving HIV remission and improving long-term health outcomes. It is crucial to consult with an infectious disease specialist to discuss the most appropriate treatment options and develop a personalized management plan.

Dr.Camel's Conclusion

This study provides valuable insights into the factors influencing time to viral rebound after ART interruption in individuals with HIV. It's like learning the secrets of the desert, understanding the winds and the shifting sands. The findings highlight the potential for HIV remission and the importance of early ART initiation in achieving this goal. This research, much like a camel discovering a new oasis in the desert, offers hope for a brighter future for those living with HIV.

Date :
  1. Date Completed 2022-03-15
  2. Date Revised 2022-09-28
Further Info :

Pubmed ID

34117753

DOI: Digital Object Identifier

PMC8906742

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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