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Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome.

Author: BoboWilliam V, BrodyBenjamin, GaoKeming, JanosJessica A, KamaliMasoud, KetterTerence A, McElroySusan L, McInnisMelvin G, NierenbergAndrew, PeggSamantha, RabideauDustin J, Reilly-HarringtonNoreen A, SheltonRichard C, SylviaLouisa G, TohenMauricio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Bipolar disorder can be divided into stages, with more advanced stages linked to worse outcomes. People with bipolar disorder also tend to have more depressive or manic episodes. This study found that the stage of the disorder and whether someone has more depressive or manic episodes were related to several factors, such as childhood abuse, anxiety, and past treatments. However, these factors didn't influence how well two medications, lithium and quetiapine, worked. The number of depressive episodes in the past year was linked to poorer treatment outcomes overall. This suggests that early intervention is key for better outcomes in bipolar disorder.
Paper Details　
Original Abstract of the Article :
Bipolar disorder often follows a set progression best described in stages where advanced stages are associated with poorer outcomes. Bipolar disorder is also often characterized by a predominance of episode polarity, where some individuals experience more depressive episodes (termed predominant depr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34118638

データ提供：米国国立医学図書館（NLM）

Illness Stage and Predominant Polarity in Bipolar Disorder: Impact on Burden and Treatment

Navigating the [complexities of bipolar disorder] requires understanding the [progression and characteristics] of this multifaceted condition. This study delves into the relationship between [illness stage, predominant polarity, burden of illness, and treatment outcome] in bipolar disorder. The researchers analyzed data from a [six-month comparative effectiveness trial] of [lithium and quetiapine], examining how [staging and polarity] influenced [measures of illness burden and treatment response]. Their findings highlight the importance of [early intervention] and provide valuable insights into the [impact of illness stage and polarity] on [treatment effectiveness] in bipolar disorder.

The Significance of Illness Stage and Predominant Polarity in Bipolar Disorder

The study revealed a [strong correlation] between [illness stage, predominant polarity, and various measures of illness burden], including [past trials of psychotropics, anxiety disorder comorbidity, and childhood abuse]. These findings highlight the [crucial role of early identification and intervention] to [mitigate the impact of bipolar disorder] on individuals' lives. While [staging and polarity] did not directly moderate the treatment effect of [lithium vs. quetiapine], the study identified [number of depressive episodes in the past year] as a potential predictor of [overall worse treatment outcome].

Prioritizing Early Intervention in Bipolar Disorder

This study underscores the importance of [early intervention and personalized treatment approaches] for [managing bipolar disorder]. By recognizing the [impact of illness stage and predominant polarity] on [treatment effectiveness], healthcare providers can tailor treatment strategies to [individual patient needs and optimize treatment outcomes].

Dr.Camel's Conclusion

Just as a camel adapts to the changing desert conditions, individuals with bipolar disorder must navigate the complexities of their condition. This study emphasizes the importance of early intervention and personalized treatment approaches to manage bipolar disorder effectively. By understanding the impact of illness stage and predominant polarity, we can empower individuals with bipolar disorder to achieve greater stability and improve their overall well-being.

Date :
  1. Date Completed 2021-08-05
  2. Date Revised 2022-08-02
Further Info :

Pubmed ID

34118638

DOI: Digital Object Identifier

NIHMS1711013

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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