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Asymmetric Synthesis of Fluoro, Fluoromethyl, Difluoromethyl, and Trifluoromethylcyclopropanes.

Author: CharetteAndré B, DelionLaetitia, JubaultPhilippe, PoissonThomas, PonsAmandine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study describes the development of new methods for the stereoselective synthesis of fluorine-containing cyclopropanes, which are important building blocks for drug development. The study highlights the use of diazo-derived rhodium carbenes, zinc carbenoids, ring closure processes, and biocatalytic methods to achieve high diastereo- and enantioselectivities in the synthesis of these compounds. The study provides a valuable contribution to the field of fluorine chemistry and drug discovery.
Paper Details　
Original Abstract of the Article :
Fluorine-containing cyclopropanes are a subclass of cyclopropane derivatives that have generated considerable interest in medicinal chemistry for several decades. The replacement of a cyclopropane C-H or C-CH<sub>3</sub> bond with fluorine or a fluorinated group (such as CF<sub>3</sub> or CF<sub>2</...See full text at original site
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引用元：
https://doi.org/10.1021/acs.accounts.1c00261

データ提供：米国国立医学図書館（NLM）

Fluorinated Cyclopropanes: Building Blocks for New Medicines

Fluorinated cyclopropanes are a class of molecules that have shown promise as building blocks for new medicines. This study explored the development of new synthetic methods for stereoselective synthesis of these molecules. It's like building a sandcastle in the desert, carefully shaping the grains of sand to create a beautiful and sturdy structure.

New Methods for Synthesizing Fluorinated Cyclopropanes

The researchers developed several new methods for synthesizing fluorinated cyclopropanes, including using diazo-derived rhodium carbenes, zinc carbenoids, ring closure processes, and biocatalytic methods. These methods offer greater control over the stereochemistry of the resulting molecules. This is like having a variety of tools for shaping the sand, allowing for greater precision and creativity in building the castle.

Developing New Medicines

The development of new methods for synthesizing fluorinated cyclopropanes is a significant step towards the discovery of new medicines. This research opens up exciting possibilities for creating novel therapies for a wide range of diseases. It's like finding a new source of precious resources in the desert, providing the potential for building a thriving civilization.

Dr.Camel's Conclusion

This study showcases the ingenuity and creativity of chemists in developing new synthetic methods for creating fluorinated cyclopropanes. It's a testament to human ingenuity and the potential for scientific discovery to find solutions to challenges, just like finding a hidden oasis in the desert.

Date :
  1. Date Completed 2021-09-02
  2. Date Revised 2021-09-02
Further Info :

Pubmed ID

34232626

DOI: Digital Object Identifier

10.1021/acs.accounts.1c00261

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English

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