Effective treatment of dandelion: A Synthesis of Findings from 7 Studies

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Original Abstract of the Article

Major Research Findings

Several studies suggest that dandelion may have various health benefits. For example, a study ( 1 ) showed that vardenafil, a component of dandelion, increased the accumulation of a mutated protein responsible for cystic fibrosis in lung cells. Another study ( 3 ) suggested that dandelion components might be beneficial in preventing osteoporosis. Furthermore, a study ( 5 ) indicated that dandelion could potentially help treat multisystem inflammatory syndrome in children (MIS-C), a serious condition associated with severe acute respiratory syndrome coronavirus 2 infection.

Benefits and Risks

Benefit Summary

Dandelion has the potential to contribute to lung health, bone health, immune system strengthening, and even treatment for MIS-C.

Risk Summary

While dandelion is widely used as a common herb, it's crucial to consult a doctor before consumption due to potential interactions with certain medications and potential allergic reactions.

Comparison Across Studies

Commonalities in Studies

These studies point toward the possibility of dandelion having positive effects on various health issues.

Differences in Studies

These studies utilized different methodologies to investigate dandelion's effects. For example, 1 employed cell cultures, while 3 focused on human bone cells.

Consistency and Discrepancies in Results

While these studies indicate the potential for dandelion to benefit health, they primarily focus on specific components of dandelion, making it challenging to draw conclusions about the overall effects of the plant. Additionally, these studies are relatively small in scale, necessitating further research.

Cautions for Real-Life Application

Further research is necessary to determine how these findings can be applied to everyday life. It's essential to consume dandelion under the guidance of a healthcare professional.

Limitations of Current Research

Research on the effects of dandelion is still in its early stages and requires further investigation. Key areas for future research include the effects of specific dandelion components, the long-term effects of dandelion, and its safety.

Future Research Directions

Future research should delve into the effects of specific components of dandelion, its long-term effects, and its safety. Additionally, studies investigating how dandelion affects various diseases and symptoms are needed.

Conclusion

While dandelion might offer various health benefits, its effects are not yet fully understood. It's crucial to consult a healthcare professional before consuming dandelion.

Literature analysis of 7 papers
Positive Content
7
Neutral Content
0
Negative Content
0
Article Type
1
1
1
1
7
1.

Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells.

Author: DhoogheBarbara, BouzinCaroline, MottaisAngélique, HermansEmmanuel, DelionMartial, PaninNadtha, NoelSabrina, LealTeresinha

CFTR-dependent chloride transport

This study investigated the effects of vardenafil, a PDE5 inhibitor, on CFTR function in cystic fibrosis (CF) cells. Vardenafil partially rescued F508del CFTR function through mechanisms independent of cGMP/PKG pathways, suggesting its potential as a therapeutic agent for CF.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Bone demineralization is improved by ivacaftor in patients with cystic fibrosis carrying the p.Gly551Asp mutation.

Author: Sermet-GaudelusIsabelle, DelionMartial, DurieuIsabelle, JacquotJacky, HubertDominique

Ivacaftor for BMD

Ivacaftor was found to improve bone mineral density in cystic fibrosis patients carrying the p.Gly551Asp mutation. In vitro experiments showed that correcting p.Phe508del-CFTR significantly reduced RANKL protein production, which plays a major role in bone resorption. These findings suggest that restoring mutated CFTR protein enhances bone remodeling and highlights the link between CFTR and bone cell function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Overexpression of RANKL in osteoblasts: a possible mechanism of susceptibility to bone disease in cystic fibrosis.

Author: DelionMartial, BrauxJulien, JourdainMarie-Laure, GuillaumeChristine, BourCamille, GangloffSophie, Pimpec-BarthesFrançoise Le, Sermet-GaudelusIsabelle, JacquotJacky, VelardFrédéric

CFBD treatment

This study investigated the involvement of defective CFTR in the production of RANKL and OPG in CF primary human osteoblasts. The study found that defective CFTR is related to the overexpression of RANKL and high membranous RANKL localization in osteoblasts, which may worsen bone resorption and lead to bone loss in patients with CF.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children.

Author: OuldaliNaïm, ToubianaJulie, AntonaDenise, JavouheyEtienne, MadhiFouad, LorrotMathie, LégerPierre-Louis, GaleottiCaroline, ClaudeCaroline, WiedemannArnaud, LachaumeNoémie, OvaertCaroline, DumortierMorgane, KahnJean-Emmanuel, MandelcwajgAlexis, PercheronLucas, BiotBlandine, BordetJeanne, GirardinMarie-Laure, YangDavid Dawei, GrimaudMarion, OualhaMehdi, AllaliSlimane, BajolleFanny, BeylerConstance, MeinzerUlrich, LevyMichael, PauletAna-Maria, LevyCorinne, CohenRobert, BelotAlexandre, AngoulvantFrançois,

Fever course improvement
Reduced PICU stay
Reduced acute left ventricular dysfunction
Reduced hemodynamic support
Reduced second-line therapy

Among children with multisystem inflammatory syndrome in children (MIS-C), treatment with intravenous immunoglobulins (IVIG) and methylprednisolone was associated with a more favorable fever course than IVIG alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Developmental and sequenced one-to-one educational intervention (DS1-EI) for autism spectrum disorder and intellectual disability: a two-year interim report of a randomized single-blind multicenter controlled trial.

Author: TanetAntoine, Hubert-BarthelemyAnnick, ClémentMarie-Noëlle, SoumilleFrançois, CrespinGraciela C, PellerinHugues, AllaertFrançois-André, CohenDavid, Saint-GeorgesCatherine,

Improve education

This study assessed the feasibility and efficacy of a new intervention model using an individualized educational approach for children with autism spectrum disorder (ASD) and moderate to severe intellectual disability (ID).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effect of dance therapy on blood pressure and exercise capacity of individuals with hypertension: A systematic review and meta-analysis.

Author: ConceiçãoLino Sergio Rocha, NetoMansueto Gomes, do AmaralMayra Alves Soares, Martins-FilhoPaulo Ricardo Saquete, Oliveira CarvalhoVitor

Improved exercise capacity
Reduced DBP
Reduced SBP

Dance therapy was found to be effective in reducing systolic blood pressure (SBP) by 12.01 mmHg and diastolic blood pressure (DBP) by 3.38 mmHg in hypertensive patients. Exercise capacity also showed a significant improvement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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