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Current status of fecal microbiota transplantation for irritable bowel syndrome.

Author: El-SalhyMagdy, HatlebakkJan Gunnar, HauskenTrygve

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Fecal microbiota transplantation (FMT) shows promise for treating irritable bowel syndrome (IBS), but its efficacy is donor-dependent. A review of 7 RCTs found that FMT was effective in some studies but not others. The selection of donors with favorable microbiota signatures and further research on optimal dosing and routes of administration are crucial for improving FMT outcomes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Irritable bowel syndrome (IBS) is a common gastrointestinal functional disorder. Although IBS is a benign condition, it reduces the quality of life considerably. While there is currently no effective treatment for this disorder, fecal microbiota transplantation (FMT) seems to be promisin...See full text at original site
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引用元：
https://doi.org/10.1111/nmo.14157

データ提供：米国国立医学図書館（NLM）

Fecal Microbiota Transplantation for IBS: Exploring a New Frontier

In the ever-evolving landscape of [gastrointestinal disorders], [irritable bowel syndrome (IBS)] presents a significant challenge for [patients and clinicians] alike. This review examines the [potential of fecal microbiota transplantation (FMT)] as a [novel treatment approach] for [IBS]. The authors conducted a [systematic review] of the literature to [assess the evidence] for the [efficacy and safety of FMT] in [IBS patients].

A Promising Path: FMT's Potential for IBS Treatment

The review reveals a [mixed picture] regarding the [effectiveness of FMT] for [IBS], with some studies showing [positive effects] while others did not. The authors emphasize the [importance of donor selection] and the [need for further research] to [optimize FMT protocols] for [IBS].

A New Era in IBS Management: Tailoring Treatment to the Individual

This research suggests that [FMT] may be a [promising therapeutic avenue] for [some IBS patients] but requires [further investigation] to [understand the optimal donor characteristics, dosing, and administration methods] to [maximize its effectiveness].

Dr. Camel's Conclusion

Like a caravan traveling across the desert, the journey to finding effective treatments for IBS is ongoing. This review offers a valuable roadmap, highlighting the potential of FMT while acknowledging the need for continued exploration and refinement.

Date :
  1. Date Completed 2022-03-03
  2. Date Revised 2022-03-03
Further Info :

Pubmed ID

34236740

DOI: Digital Object Identifier

10.1111/nmo.14157

Related Literature

Article Analysis
・Effective treatment of irritable bowel syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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