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Therapeutic effects of quinine in a mouse model of atopic dermatitis.

Author: ChenSi, HuangJingkai, JiangHongjing, LiXinchen, LiuMiao, LyuYansi, WangLi, ZhangQian, ZhouMurong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the therapeutic effects of quinine, a bitter taste receptor agonist, in atopic dermatitis (AD)-like mice. Quinine was found to reduce skin damage, IgE expression, cytokine secretion, and scratching frequency, while increasing filaggrin expression and repairing the skin barrier. These findings suggest that quinine may have therapeutic potential for the treatment of AD.
Paper Details　
Original Abstract of the Article :
Atopic dermatitis (AD) is a chronic inflammatory skin disease that seriously affects quality of life. Quinine is a bitter taste receptor agonist that exhibits antimalarial effects. The aim of the present study was to examine the therapeutic effects of quinine in AD‑like mice. AD was induced with 2,4...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974254/

データ提供：米国国立医学図書館（NLM）

Quinine: A Potential Oasis in the Desert of Atopic Dermatitis

Atopic dermatitis, a chronic inflammatory skin condition, can feel like a relentless desert storm for those affected. This study explores the therapeutic potential of quinine, a bitter-tasting compound known for its antimalarial properties, in treating atopic dermatitis in a mouse model.

Quinine's Journey: From Malaria to Atopic Dermatitis

Researchers observed that quinine significantly ameliorated skin damage in the mice, reducing IgE expression and inhibiting the inflammatory cascade. This intriguing discovery suggests that quinine might offer a novel approach to managing atopic dermatitis.

Hope on the Horizon

While further research is necessary to confirm the effectiveness of quinine in humans, these findings provide a glimmer of hope in the fight against atopic dermatitis. The potential of repurposing existing medications like quinine for new therapeutic applications is a promising area of research.

Dr. Camel's Conclusion

This study is like finding a hidden spring in the middle of a scorching desert. Quinine, a compound known for its antimalarial effects, shows promise for treating atopic dermatitis. It’s a reminder that nature holds many secrets, and with further investigation, these secrets could offer solutions to challenging health conditions.

Date :
  1. Date Completed 2021-09-13
  2. Date Revised 2021-09-13
Further Info :

Pubmed ID

34240224

DOI: Digital Object Identifier

PMC7974254

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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