Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues.

Author: CassarinoMaria Francesca, CastelliLuigi, Pecori GiraldiFrancesca, SestaAntonella, TapellaLaura

Paper Details 
Original Abstract of the Article :
Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting adenoma and indicated that retinoids might act also on the adre...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275666/

データ提供:米国国立医学図書館(NLM)

Decoding the Dual Nature of 9-cis Retinoic Acid in Cushing's Syndrome

The [endocrine system] plays a critical role in maintaining [hormonal balance], and imbalances can lead to various health complications. This research investigates the complex effects of [9-cis retinoic acid] on [ACTH-dependent hyperplastic adrenal tissues] in patients with [Cushing's syndrome]. The authors explore the [dual actions] of [9-cis retinoic acid], revealing its potential to both [stimulate] and [inhibit] [cortisol secretion] depending on the presence of [ACTH].

A Complex Dance of Hormones: Unraveling the Secrets of 9-cis Retinoic Acid

This study unveils the fascinating interplay between [9-cis retinoic acid] and [ACTH] in the context of [Cushing's syndrome]. The authors' findings demonstrate that [9-cis retinoic acid] can exert both [stimulatory] and [inhibitory] effects on [cortisol secretion], highlighting the complexity of [hormonal regulation] in this condition. Their research provides valuable insights into the potential [therapeutic] applications of [9-cis retinoic acid] in managing [Cushing's syndrome].

A New Approach to Cushing's Syndrome: Harnessing the Power of Retinoids

This research offers a potential new avenue for [Cushing's syndrome] treatment. The authors' exploration of [9-cis retinoic acid's] effects on [adrenal tissues] provides a foundation for developing [targeted therapies] that can effectively manage [cortisol levels] and improve patient outcomes. This study underscores the importance of [understanding the complex interactions] within the [endocrine system] in developing effective treatment strategies.

Dr. Camel's Conclusion

Just as a camel can adapt to the fluctuating temperatures and unpredictable conditions of the desert, researchers are exploring the complex actions of [9-cis retinoic acid] in the context of [Cushing's syndrome]. This research sheds light on the potential of [retinoids] to play a crucial role in managing this condition, offering hope for improved patient outcomes and a better quality of life.

Date :
  1. Date Completed 2021-11-05
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

34253781

DOI: Digital Object Identifier

PMC8275666

Related Literature

SNS
PICO Info
in preparation
Languages

English

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