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A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders.

Author: BucsaCamelia, FarcasAndreea, HurubaMadalina, LeucutaDaniel Corneliu, MogosanCristina, SiposMariana

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fluoroquinolones are a class of antibiotics that can cause serious musculoskeletal side effects, such as tendonitis and arthralgia. This study analyzed reports of FQ-associated disabling musculoskeletal disorders from VigiBase and found that levofloxacin and ciprofloxacin were the most commonly reported drugs associated with these side effects.
Paper Details　
Original Abstract of the Article :
Recent drug safety concerns described fluoroquinolone (FQ)-induced serious musculoskeletal reactions. The objective of this study was to characterize reports with FQ-associated disabling musculoskeletal disorders, from VigiBase. The analysis included all FQ-induced musculoskeletal and connective tis...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277836/

データ提供：米国国立医学図書館（NLM）

Fluoroquinolones: A Closer Look at Musculoskeletal Risks

The use of [fluoroquinolones (FQs)] is widespread, but recent concerns have emerged regarding their potential to cause [disabling musculoskeletal and connective tissue disorders]. This research delves into a descriptive study of [VigiBase] reports, examining the nature and frequency of FQ-associated musculoskeletal adverse drug reactions. The analysis reveals a significant number of reports involving disabling musculoskeletal disorders, including [arthralgia, tendonitis, and pain in extremity]. The authors highlight the importance of recognizing and managing these potential risks, particularly for patients receiving FQ treatment.

Understanding the Risks: A Call for Vigilance

The study's findings serve as a valuable reminder of the potential risks associated with [FQ use]. The authors' analysis of [VigiBase] reports highlights the need for ongoing surveillance and vigilance in recognizing and managing these potential adverse drug reactions. This research underscores the importance of a balanced approach to FQ prescribing, carefully weighing the potential benefits against the risks.

Safety First: Navigating the Fluoroquinolone Landscape

This study provides a comprehensive overview of the potential [musculoskeletal risks] associated with [FQ use]. It emphasizes the importance of a careful evaluation of patient risk factors and a cautious approach to FQ prescribing. This research highlights the need for ongoing monitoring and vigilant management of potential adverse drug reactions in patients receiving FQ treatment.

Dr.Camel's Conclusion

This research is a reminder that even seemingly familiar medications can have unexpected side effects. It's like a desert mirage – what appears safe and beneficial might conceal hidden dangers. The authors' study underscores the need for vigilance, careful monitoring, and a thorough understanding of potential risks associated with FQ use.

Date :
  1. Date Completed 2021-12-06
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

34257376

DOI: Digital Object Identifier

PMC8277836

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Article Analysis
・Side Effects of ofloxacin
SNS
PICO Info
in preparation
Languages

English

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