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Dose-response effects in immunizations with keyhole limpet haemocyanin and rabies vaccine: shift in some immunodeficiency states.

Author: BoeschotenE W, KorverK, KredietR T, SchellekensP T, van SteenisG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Patients with uraemic disease on chronic intermittent haemodialysis had a deficient primary antibody response to antigens, but this was reversed by using a supra-optimal antigen dose. This suggests that the dose-response curve of a particular antigen may be shifted towards higher doses of antigen in immunodeficiency states.
Paper Details　
Original Abstract of the Article :
We investigated the primary antibody response to the antigens keyhole limpet haemocyanin (KLH) and rabies vaccine (RV). Eighty-one healthy volunteers were injected with nine doses of KLH (ranging from 10 to 2500 micrograms) and 66 volunteers with six doses of RV (ranging from 17 to 680 micrograms pr...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542077/

データ提供：米国国立医学図書館（NLM）

Unraveling the Mystery of Immunodeficiency: A Dose-Response Journey

This research delves into the complex world of immunodeficiency, exploring the dose-response relationship in immunizations with keyhole limpet haemocyanin (KLH) and rabies vaccine (RV). The study, like a camel navigating the vast desert of immunology, investigates the antibody responses of healthy volunteers and patients with uraemic disease. The findings reveal that patients with uraemic disease exhibit a shifted dose-response curve, suggesting that a higher dose of antigen might be needed to elicit an effective immune response. This discovery is like finding a hidden oasis in the desert of immunodeficiency, offering a potential solution for optimizing immune responses in compromised individuals.

A New Perspective on Immunizations in Compromised Individuals

This research provides valuable insights into the immune responses of patients with uraemic disease. The findings suggest that a higher dose of antigen might be needed to elicit an effective immune response in these individuals, offering a new perspective on immunization strategies for compromised populations.

Navigating the Desert of Immunodeficiency

This research sheds light on the complex interplay between antigen dose and immune response in individuals with immunodeficiency. The findings emphasize the importance of personalized approaches to immunization, tailoring strategies to meet the specific needs of each patient. This discovery is like finding a new path through the desert of immunodeficiency, guiding healthcare professionals towards more effective treatment options.

Dr.Camel's Conclusion

This research delves into the intricate world of immunodeficiency, revealing the importance of adjusting antigen doses to optimize immune responses. The findings offer a potential new approach to immunization strategies for compromised individuals, providing a vital tool for improving their health and well-being. This discovery is like finding a hidden spring in the desert of immunodeficiency, offering a potential source of renewed vitality for individuals with weakened immune systems.

Date :
  1. Date Completed 1988-03-23
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

3427825

DOI: Digital Object Identifier

PMC1542077

Related Literature

Article Analysis
・Effects of rabies vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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