Effects of Local Administration of Tranexamic Acid on Reducing Postoperative Blood Loss in Surgeries for Closed, Sanders III-IV Calcaneal Fractures: A Randomized Controlled Study.

Effects of Local Administration of Tranexamic Acid on Reducing Postoperative Blood Loss in Surgeries for Closed, Sanders III-IV Calcaneal Fractures: A Randomized Controlled Study

Calcaneal fractures, particularly those classified as Sanders III-IV, pose significant challenges for surgeons due to their complexity and the potential for substantial blood loss during surgery. This study investigates the efficacy of local administration of tranexamic acid (TXA), an antifibrinolytic agent, in reducing postoperative blood loss during surgical procedures for Sanders III-IV calcaneal fractures. The study randomly assigned patients to receive either 10 mg/ml or 20 mg/ml TXA solutions, or saline as a control, perfused into the surgical incision. The results demonstrated a significant reduction in postoperative drainage volume, hemoglobin, and hematocrit levels in the TXA groups compared to the control group. Importantly, no significant differences were observed in platelet counts, prothrombin time, activated partial prothrombin time, or wound complications between the groups.

Minimizing Blood Loss: A Promising Solution

The study's findings provide compelling evidence for the efficacy of local TXA administration in reducing postoperative blood loss during surgeries for Sanders III-IV calcaneal fractures. The authors demonstrate that TXA can effectively minimize blood loss without increasing the risk of adverse events, making it a valuable tool for improving patient outcomes.

Improving Patient Safety and Recovery

The use of local TXA offers a promising approach to improve patient safety and facilitate recovery following surgery for complex calcaneal fractures. By minimizing blood loss, TXA can reduce the risk of complications and accelerate the healing process. The study's findings are particularly relevant for patients with underlying medical conditions that may increase their risk of complications associated with blood loss.

Dr.Camel's Conclusion

This study is a shining oasis in the desert of surgical challenges, offering a practical and effective solution for reducing blood loss during complex calcaneal fracture surgery. The authors' findings highlight the potential of TXA to enhance patient safety and facilitate a smoother recovery journey.