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Implications of dopaminergic medication withdrawal in Parkinson's disease.

Author: JostW H, KoschelJ, RaederV, Ray ChaudhuriK, ThielM, TöngesL

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Tapering off dopamine replacement therapy (DRT) in Parkinson's disease (PD) requires careful consideration due to the risk of severe withdrawal symptoms. Abrupt discontinuation or rapid reduction of dopamine agonists or amantadine can lead to life-threatening consequences. Further research is needed to establish evidence-based recommendations for tapering off DRT.
Paper Details　
Original Abstract of the Article :
The trajectory of the use of dopamine replacement therapy (DRT) in Parkinson's disease (PD) is variable and doses may need to be increased, but also tapered. The plan for dose adjustment is usually done as per drug information recommendations from the licensing bodies, but there are no clear guideli...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319886/

データ提供：米国国立医学図書館（NLM）

Navigating the Complexities of Dopamine Replacement Therapy in Parkinson's Disease

Parkinson's disease, like a sandstorm sweeping across the desert, disrupts the delicate balance of movement and control. This study examines the complexities of dopamine replacement therapy (DRT), a common treatment for this debilitating condition.

The Challenge of Dosage Adjustment: A Balancing Act

The researchers highlight the variability in DRT dosage requirements, often necessitating both increases and reductions to manage symptoms effectively. This is like a camel caravan adjusting its route to avoid obstacles and find the best path through the desert.

The Risks of Abrupt Withdrawal: A Critical Concern

The study emphasizes the importance of careful tapering off of DRT medications, as sudden reductions can lead to serious adverse consequences. This is akin to a traveler who must gradually acclimate to the changing climate and terrain to avoid exhaustion or illness.

Dr. Camel's Conclusion

The management of Parkinson's disease with dopamine replacement therapy requires careful attention to dosage adjustments. This study underscores the importance of a gradual and systematic approach to tapering off medications, emphasizing the need for personalized care to ensure a smooth and safe journey through the desert of Parkinson's disease.
Date :
  1. Date Completed 2022-09-13
  2. Date Revised 2022-11-20
Further Info :

Pubmed ID

34324057

DOI: Digital Object Identifier

PMC8319886

SNS
PICO Info
in preparation
Languages

English

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