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Development and evaluation studies of Corylin loaded nanostructured lipid carriers gel for topical treatment of UV-induced skin aging.

Author: GuoPan, LiNan, LiuTao, LiuZhidong, MaHongfei, PiJiaXin, QiDongli, TianBaoCheng, WangXiang, WangZijing, YangYi, ZhaoZhiyue, ZhuShan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential of nanostructured lipid carriers (NLC) to enhance the skin permeation of Corylin, a natural compound with photoaging benefits. Corylin-NLCs showed significant suppression of LDH release, reduced MDA content, increased antioxidant enzyme activity, and improved histopathological lesions in UVB-irradiated HaCaT cells and mice. The findings suggest that Corylin-NLCs are a promising strategy for improving the therapeutic efficacy of photoaging.
Paper Details　
Original Abstract of the Article :
We prepared nanostructured lipid carriers (NLC) to promote skin permeation of Corylin so that it can increase its effect on photoaging. Corylin-NLCs were prepared and characterized based on morphology, particle size, zeta potentials, FTIR and DSC. In vitro, we assess the cytotoxicity and lactate deh...See full text at original site
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引用元：
https://doi.org/10.1016/j.exger.2021.111499

データ提供：米国国立医学図書館（NLM）

Corylin for UV-Induced Skin Aging: A Novel Approach to Desert-Like Skin

Ultraviolet (UV) radiation, like the relentless sun beating down on a desert, can wreak havoc on our skin, causing premature aging and damage. This study, published in the field of [研究分野], investigates the potential benefits of Corylin, a natural compound, in treating UV-induced skin aging. The researchers formulated nanostructured lipid carriers (NLCs) to enhance Corylin's delivery and efficacy. They conducted in vitro and in vivo studies to evaluate Corylin-NLC's effects on skin cells and in a mouse model of UV-induced aging. They found that [主要な発見], suggesting that Corylin-NLC may offer a promising approach to combatting UV-induced skin aging. A key finding was that [特筆すべき結果や意義].

Corylin-NLC: A Potential Oasis in the Desert of Skin Aging

The study highlights the potential of Corylin-NLC as a novel approach to treating UV-induced skin aging. It's like finding a hidden oasis in the desert of aging skin, offering potential rejuvenation and protection from the harsh effects of UV radiation. Further research is needed to confirm its effectiveness and safety in human trials.

Navigating the Desert of Skin Aging: Seeking Natural Solutions

This study encourages the exploration of natural remedies for skin health. As with any desert journey, seeking natural solutions can lead to unexpected discoveries and benefits. While further research is essential, the potential of Corylin-NLC in combating UV-induced skin aging is promising.

Dr. Camel's Conclusion

This study offers a compelling case for the potential of Corylin-NLC as a novel approach to treating UV-induced skin aging. By enhancing Corylin's delivery and efficacy, this innovative formulation offers a promising solution for combating the damaging effects of UV radiation and preserving youthful skin.

Date :
  1. Date Completed 2021-09-15
  2. Date Revised 2021-09-15
Further Info :

Pubmed ID

34329721

DOI: Digital Object Identifier

10.1016/j.exger.2021.111499

Related Literature

Article Analysis
・Effective treatment of skin aging
SNS
PICO Info
in preparation
Languages

English

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