Effective treatment of skin aging: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors. These include genetic factors, cellular metabolism, hormones, metabolic processes, and external factors like UV radiation, pollution, ionizing radiation, chemicals, and toxins. 16 , 21

Studies have explored various approaches to address skin aging. For instance, 11 showed that a combined treatment of human adipose tissue stem cell-derived exosome-containing solution and microneedling is effective in improving facial skin aging. 25 demonstrated the efficacy of mesotherapy formulations containing multiple components like vitamins, minerals, amino acids, nucleotides, coenzymes, antioxidants, and hyaluronic acid in slowing down and correcting skin aging changes.

Furthermore, 23 reported that LR2412-Cx, a plant-derived anti-aging compound belonging to the jasmonate class, reduced photoaging and wrinkles, while also stimulating collagen, hyaluronic acid, and fibrillin production.

Recent research has highlighted the potential of nanotechnology-based drug delivery systems for skin aging treatment. 26 investigated the effectiveness of a liquid crystalline system containing retinyl palmitate for treating skin aging.

Treatment Summary

11 found that combining human adipose tissue stem cell-derived exosome-containing solution with microneedling effectively improved facial skin aging.

25 highlighted the effectiveness of multi-component mesotherapy formulations in treating skin aging.

23 demonstrated the effectiveness of LR2412-Cx, a plant-derived anti-aging compound, for skin aging treatment.

26 explored the potential of a liquid crystalline system containing retinyl palmitate for treating skin aging.

Benefits and Risks

Benefits Summary

These studies suggest that various approaches can be effective in addressing skin aging. Combinations like human adipose tissue stem cell-derived exosome-containing solution and microneedling, multi-component mesotherapy formulations, plant-derived anti-aging compounds, and nanotechnology-based drug delivery systems hold promise for improving skin aging and restoring youthful appearance. However, it's important to note that not all treatments have been fully proven for their effectiveness and safety, and individual responses can vary.

Risks Summary

While generally considered safe, these treatments may have side effects. Microneedling, for instance, can cause pain, swelling, and redness. Mesotherapy formulations might trigger allergic reactions. Plant-derived anti-aging compounds and nanotechnology-based drug delivery systems are still under investigation, and their long-term effects are not fully understood.

Comparison Between Studies

Commonalities

These studies share the common goal of investigating diverse approaches to improve skin aging. They contribute to understanding the mechanisms of skin aging at the cellular and tissue level.

Differences

Direct comparisons between these studies are challenging due to variations in the investigated treatments, study design, and evaluation methods. For instance, 11 evaluated the combined efficacy of human adipose tissue stem cell-derived exosome-containing solution and microneedling, whereas 25 assessed the effectiveness of multi-component mesotherapy formulations. Comprehensive interpretation of these findings requires further research.

Consistency and Discrepancies in Results

While these studies suggest the potential effectiveness of various approaches for skin aging treatment, some inconsistencies and discrepancies exist. 11 demonstrated the efficacy of combining human adipose tissue stem cell-derived exosome-containing solution with microneedling, while other studies reported the effects of microneedling alone. A more comprehensive understanding of these findings requires further research.

Real-World Application Considerations

The effectiveness of skin aging treatments can vary between individuals. It's crucial to consult with a doctor or specialist before starting any treatment. If side effects occur during treatment, seek immediate medical attention.

Limitations of Current Research

These studies have limitations such as small sample sizes and short follow-up durations, hindering the generalization of findings. Further research with larger samples and longer follow-up periods is necessary. Long-term effects of these treatments have not been fully evaluated, requiring further investigation to assess their long-term safety.

Future Research Directions

Future research should focus on larger sample sizes, longer follow-up periods to assess long-term effects, and include diverse age groups and skin types for a more comprehensive understanding of treatment efficacy. Research is also needed to confirm the safety of these treatments.

Conclusion

These studies suggest the potential effectiveness of various approaches for treating skin aging, but further research is needed to establish their effectiveness and safety. If you're interested in skin aging treatments, consult with a doctor or specialist.

Treatment List

Human adipose tissue stem cell-derived exosome-containing solution and microneedling, multi-component mesotherapy formulations, plant-derived anti-aging compounds, nanotechnology-based drug delivery systems

Literature analysis of 27 papers
Positive Content
26
Neutral Content
0
Negative Content
1
Article Type
13
0
1
4
26
1.

Safety and efficacy of two anti-acne/anti-aging treatments in subjects with photodamaged skin and mild to moderate acne vulgaris.

Author: KircikLeon H, DahlAmanda, YatskayerMargarita, RaabSusana, OresajoChristian

Dual-action formulation
Targets acne and aging
Treatment of acne and skin aging
Not specified
Prevalence data lacking

While exact numbers are unknown, adult acne is common, and many people experience both acne and early signs of aging. A new treatment (Treatment A) has been developed for daily use to address both acne and signs of aging. This over-the-counter formulation includes ingredients that target the causes of acne while also addressing aging skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

A high-potency, multimechanism skin care regimen provides significant antiaging effects: results from a double-blind, vehicle-controlled clinical trial.

Author: FarrisPatricia K, EdisonBrenda L, BroudaIrina, WeinkaufRonni L, GreenBarbara A

Skin aging treatment

Skin aging involves wrinkles, uneven pigmentation, and loss of firmness. No single ingredient or non-invasive treatment can fully address all aspects of aging skin. A comprehensive approach using proven skincare products is recommended. This study examines a skincare regimen containing multiple active ingredients, aiming to improve signs of aging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Anti-aging and filling efficacy of six types hyaluronic acid based dermo-cosmetic treatment: double blind, randomized clinical trial of efficacy and safety.

Author: NobileVincenzo, BuonocoreDaniela, MichelottiAngela, MarzaticoFulvio

Skin aging treatment

Skin aging is a complex process involving multiple factors. While the exact mechanisms of skin aging are not fully understood, it's clear that the outer layer of skin loses a key molecule that helps retain moisture, leading to dryness and other noticeable changes in aging skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The Effect in Topical Use of Lycogen(TM) via Sonophoresis for Anti-aging on Facial Skin.

Author: Hsin-TiLai, Wen-ShengLiu, Yi-ChiaWu, Ya-WeiLai, WenZhi-Hong, DavidWang Hui-Min, Su-ShinLee

Skin anti-aging

Skin aging involves thinning, dryness, uneven pigmentation, and wrinkles. While various treatments exist, from creams to surgery, they vary in effectiveness and cost. Topical anti-aging products are a convenient and affordable option. Lycogen(TM) is an antioxidant that can help reduce wrinkles by preventing collagen breakdown and damage from free radicals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial.

Author: RattanawiwatpongPattarawan, WanitphakdeedechaRungsima, BumrungpertAkkarach, MaiprasertMart

Anti-aging effects
Hydrating skin
Moisturizing skin

Topical application of vitamins C and E combined with raspberry leaf extracts may offer improved anti-aging effects for the skin compared to individual ingredients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

A new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial.

Author: CaverzanJeanifer, MussiLilian, SufiBianca, PadovaniGiovana, NazatoLucas, CamargoFlavio B, MagalhãesWagner V, Di StasiLuiz C

Topical anti-aging products
Chronic reactions
Complications

Injections used to plump up skin and treat aging can be uncomfortable, invasive, and cause complications, especially with long-term use. Scientists are working to develop new anti-aging products that can be applied to the skin and have fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study.

Author: MakinoElizabeth T, KadoyaKuniko, ChungRobin, JiangLily, MikatiMouna, MehtaRahul C

NCC for neck aging

This study investigates the efficacy and tolerability of a novel topical cosmetic cream (NCC) specifically designed for the neck and décolletage, finding significant improvements in skin sagging, wrinkles, texture, and hyperpigmentation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Effects of a combination of botanical actives on skin health and antioxidant status in post-menopausal women: A randomized, double-blind, placebo-controlled clinical trial.

Author: TumsuttiPakagamon, MaiprasertMart, SugkraroekPansak, WanitphakdeedechaRungsima, BumrungpertAkkarach

Slow skin aging
Long-term outcomes

Skin aging is a concern for women after menopause. While hormonal therapy can be effective, concerns remain about long-term outcomes. Nutraceuticals with estrogenic and antioxidative effects are being explored as an alternative therapy to slow down skin age-related changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Skin measurement devices to assess skin quality: A systematic review on reliability and validity.

Author: LangeveldMirte, van de LandeLara S, O' SullivanEimear, van der LeiBerend, van DongenJoris A

Measurement devices for skin quality

This review investigates the reliability and validity of different measurement devices used to assess the effects of treatments aimed at improving skin quality. Various treatments are available to address visible signs of aging, but the accuracy of these devices in evaluating treatment effectiveness is unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Comparison of the effects of 2 frequencies of application of photobiomodulation on facial rejuvenation: Controlled, randomized, and double-blind clinical trial.

Author: BragatoErick Frank, PiresJefferson André, MomolliMarcos, GuerraMarina Bertoni, PaisanoAdriana Fernandes, FerrariRaquel Agnelli Mesquita, BussadoriSandra Kalil, MottaLara Jansiski, FernandesKristianne Porta Santos

Skin aging treatment

Skin aging is a natural process, but it can be accelerated by factors like sun exposure, smoking, and alcohol. While treatments are being explored to slow down skin aging, research on the use of light therapy (photobiomodulation or PBM) with red light, which has shown promise, needs to address the inconsistent ways it's used.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study.

Author: ParkGyeong-Hun, KwonHyuck Hoon, SeokJoon, YangSteven Hoseong, LeeJoon, ParkByung Chul, ShinEun, ParkKui Young

Skin aging treatment
Low engraftment
Tumorigenicity

Adipose tissue stem cell-derived exosomes (ASCEs) show promise as a cell-free therapeutic agent for skin aging, overcoming limitations of mesenchymal stem cell therapy.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

HA PEGylated Filler in Association with an Infrared Energy Device for the Treatment of Facial Skin Aging: 150 Day Follow-Up Data Report.

Author: KubikPaweł, JankauJerzy, RausoRaffaele, GaladariHassan, ProtasoniMarina, GruszczyńskiWojciech, GrzankaDariusz, SmolińskaMarta, AntosikPaulina, PiesiakówMaria-Luiza, KodłubańskaLidia, ZagajewskaAnna, ŁukasikBartłomiej, StabileGiorgio, ZerbinatiNicola

Improved skin elasticity
Increased angiogenesis
Increased fibroblasts

This study evaluated the cellular and clinical response of a therapeutic protocol aimed at countering facial skin aging. It finds that a combination of an infrared energy-based device treatment with both non-cross-linked hyaluronic acid and novel PEG-cross-linked hyaluronic acid leads to numerous positive cutaneous changes after histological, immunological, and biomechanical evaluations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Assessment of clinical efficacy of lidocaine/tetracaine 7%/7% peel cream in fractional microablative laser procedure-associated pain for facial skin aging treatment. A randomized, controlled, single-blind trial.

Author: CaprariElisabetta, ViciguerraMaria Teresa, MilaniMassimo

Reduced FLR pain

Lidocaine/tetracaine 7%/7% peel cream (L/T-pC) has proven effective in reducing pain during various dermatological procedures. This study aims to investigate its efficacy in reducing pain during full-facial microablative fractional laser resurfacing sessions for facial skin aging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Current Topical Strategies for Skin-Aging and Inflammaging Treatment: Science versus Fiction.

Author: EassaHeba A, EltokhyMohamed A, FayyazHeba A, KhalifaMaha K A, ShawkySeham, HelalNada A, EassaHadeer A, YoussefShams F, LatzIsabel K, NounouMohamed Ismail

Reduced skin aging
Antioxidant efficacy uncertain

This review discusses the role and pathways of inflammaging in skin aging, and reviews strategies and current topical approaches for skin-aging treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

tBHP treatment as a model for cellular senescence and pollution-induced skin aging.

Author: WedelSophia, MarticInes, HrapovicNina, FabreSusanne, Madreiter-SokolowskiCorina T, HallerThomas, PiererGerhard, PlonerChristian, Jansen-DürrPidder, CavinatoMaria

Skin aging
Tissue damage

Senescent cells accumulate with age and contribute to age-related pathologies. This study explores the use of tert-butyl hydroperoxide (tBHP) as a model to study the effects of extrinsic skin aging, specifically focusing on the influence of environmental pollution.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Fractional radiofrequency in the treatment of skin aging: an evidence-based treatment protocol.

Author: KleidonaIleana Afroditi, KarypidisDimitrios, LoweNicholas, MyersSimon, GhanemAli

Rhytides improvement
Skin rejuvenation
Skin tightening
Edema
Erythema
Hyperpigmentation
Mild pain

This systematic review found that fractional radiofrequency (FRF) is effective for skin rejuvenation, but there is a need for large-scale, well-designed trials to better investigate its efficacy and safety and produce clear guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Aesthetic aspects of skin aging, prevention, and local treatment.

Author: ZouboulisChristos C, GancevicieneRuta, LiakouAikaterini I, TheodoridisAthanasios, ElewaRana, MakrantonakiEugenia

Anti-aging
Skin health

This review discusses the complex biological process of skin aging, influenced by both intrinsic and extrinsic factors. The review explores preventive measures, cosmetological strategies, and the mechanisms of action and effectiveness of topical pharmaceutical agents for anti-aging purposes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

A cosmetic treatment based on the secretion of Cryptomphalus aspersa 40% improves the clinical results after the use of nonablative fractional laser in skin aging.

Author: TruchueloM Teresa, VitaleMaria

Enhanced skin regeneration
Improved clinical results

A cosmetic product with Cryptomphalus aspersa (SCA) 40% applied after laser treatment for moderate photoaging was found to significantly enhance and accelerate skin regeneration, reduce adverse effects, and improve clinical results compared to a vehicle-treated side.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Dermapen in the treatment of wrinkles in cigarette smokers and skin aging effectively.

Author: AmerMohamed, FaragFawzeya, AmerAmin, ElKotRiham, MahmoudRana

Wrinkle Reduction

This paper discusses the benefits of microneedling for facial wrinkles, highlighting its effectiveness, affordability, and safety.

EditorialAn article in which the editor or publisher expresses their opinion or perspective on a particular topic or issue. Its purpose is to convey a specific message or idea to the reader.

Language : English

23.

Clinical Assessment of a Novel Jasmonate Cosmeceutical, LR2412-Cx, for the Treatment of Skin Aging.

Author: AlexiadesMacrene

Skin aging treatment
None reported

A novel jasmonate complex, LR2412-Cx, was found to be safe and effective for the cosmetic treatment of fine wrinkle appearance, texture, and pores. This suggests a potential new approach to reducing visible signs of skin aging.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Randomized, Double-Blind, Split-Face Study Evaluating Fractional Ablative Erbium:YAG Laser-Mediated Trans-Epidermal Delivery of Cosmetic Actives and a Novel Acoustic Pressure Wave Ultrasound Technology for the Treatment of Skin Aging, Melasma, and Acne Scars.

Author: AlexiadesMacrene

Acne scar improvement
Improved rhytids
Melasma improvement
Moderate erythema

Combining fractional ablative Er:YAG 2940-nm laser (FELR) with acoustic pressure wave ultrasound treatment for rhytids, melasma, and acne scars is safe and effective. Ultrasound enhances trans-epidermal delivery of topical agents, leading to greater improvement in pigment levels compared to FELR and topicals alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging.

Author: OliveiraMarcela B, do PradoAlice Haddad, BernegossiJéssica, SatoClaudia S, Lourenço BrunettiIguatemy, ScarpaMaria Virgínia, LeonardiGislaine Ricci, FribergStig E, ChorilliMarlus

Skin aging treatment

This study characterized and evaluated the in vitro safety and antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). The incorporation of RP in LCS improved the drug's safety profile and maintained its antioxidant activity. This suggests PFS-based LCS could be a promising platform for topical application of RP in treating skin aging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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