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Efficacy of topical non-steroidal immunomodulators in the treatment of oral lichen planus: a systematic review and meta-analysis.

Author: RadosPantelis Varvaki, VisioliFernanda, da SilvaEduardo Liberato, de LimaTaiane Berguemaier

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Topical non-steroidal immunomodulators (TNSIs), such as tacrolimus and pimecrolimus, are safe and effective alternatives for oral lichen planus (OLP) treatment. A meta-analysis of 28 studies found that TNSIs showed similar benefits in clinical response and symptom resolution compared to topical steroids.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The aim of this systematic review was to assess the efficacy and safety of topical non-steroidal immunomodulators (TNSIs) for oral lichen planus (OLP) treatment. MATERIALS AND METHODS: A search strategy designed for this purpose retrieved 1156 references. After analysis of titles and ab...See full text at original site
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引用元：
https://doi.org/10.1007/s00784-021-04072-7

データ提供：米国国立医学図書館（NLM）

Topical Non-Steroidal Immunomodulators: A Promising Approach for Oral Lichen Planus

The field of dermatology is constantly seeking safer and more effective treatments for chronic inflammatory conditions, such as oral lichen planus (OLP). This research investigates the efficacy and safety of topical non-steroidal immunomodulators (TNSIs) for the treatment of OLP. The authors conducted a systematic review and meta-analysis of clinical trials, examining the effectiveness of various TNSIs compared to topical steroids (TS) and placebo. This comprehensive analysis provides valuable insights into the potential of TNSIs as alternatives to traditional treatments for OLP.

Exploring New Horizons in OLP Treatment

This meta-analysis provides compelling evidence for the efficacy and safety of TNSIs, particularly tacrolimus and pimecrolimus, as alternatives to TS in the treatment of OLP. The findings demonstrate that TNSIs can effectively reduce symptoms, improve clinical response, and prevent relapses. This study highlights the importance of exploring new treatment modalities to address the needs of patients with chronic inflammatory conditions like OLP.

Managing Oral Lichen Planus

The development of TNSIs offers a promising new avenue for treating OLP, a debilitating condition that can significantly impact quality of life. By understanding the effectiveness and safety of these agents, healthcare providers can tailor treatment plans to meet the individual needs of patients with OLP, minimizing the use of systemic steroids and maximizing the benefits of targeted therapies.

Dr.Camel's Conclusion

Just as a desert plant adapts to harsh conditions, patients with OLP often seek relief from the persistent inflammation. This research provides a glimmer of hope, like a shimmering oasis in the desert, by demonstrating the effectiveness of TNSIs as alternative treatments for this challenging condition. By embracing a holistic approach to patient care, we can create a more comfortable and fulfilling life for individuals living with OLP.

Date :
  1. Date Completed 2021-08-19
  2. Date Revised 2021-08-19
Further Info :

Pubmed ID

34342763

DOI: Digital Object Identifier

10.1007/s00784-021-04072-7

Related Literature

Article Analysis
・Effects of pimecrolimus topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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