Effects of pimecrolimus topical: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major research findings

Pimecrolimus topical is effective in treating various skin conditions, including atopic dermatitis, rosacea, seborrheic dermatitis, mycosis fungoides, and oral lichen planus. 11 , 6 , 2 , 22 , 8 , 18 , 16 It can also help reduce the need for corticosteroids and has a good safety profile. 20 However, it may increase the risk of lymphoma. 15

Benefits and Risks

Benefit Summary

Pimecrolimus topical can be effective in treating various skin conditions, including atopic dermatitis, rosacea, seborrheic dermatitis, mycosis fungoides, and oral lichen planus. 11 , 6 , 2 , 22 , 8 , 18 , 16 It can also help reduce the need for corticosteroids and has a good safety profile. 20

Risk Summary

Pimecrolimus topical may cause side effects such as skin redness, burning, and itching. 11 , 20 It may also increase the risk of lymphoma. 15

Comparison Across Studies

Commonalities

Many studies have shown that pimecrolimus topical is effective in treating various skin conditions, including atopic dermatitis, rosacea, seborrheic dermatitis, mycosis fungoides, and oral lichen planus. 11 , 6 , 2 , 22 , 8 , 18 , 16 It can also help reduce the need for corticosteroids and has a good safety profile. 20

Differences

There is some variability in the assessment of the effectiveness and safety of pimecrolimus topical across studies. 11 , 6 , 2 , 22 , 8 , 18 , 16 Studies also disagree on whether pimecrolimus topical increases the risk of lymphoma. 15

Consistency and Contradictions in Results

The results across several studies consistently show that pimecrolimus topical can be effective in treating various skin conditions, including atopic dermatitis, rosacea, seborrheic dermatitis, mycosis fungoides, and oral lichen planus. 11 , 6 , 2 , 22 , 8 , 18 , 16 However, the evidence on whether pimecrolimus topical increases the risk of lymphoma is inconclusive and requires further study. 15

Cautions for Real-Life Applications

While pimecrolimus topical can be effective in treating various skin conditions, it has associated side effects. 11 , 20 Additionally, it might increase the risk of lymphoma. 15 Therefore, it is essential to consult a doctor and follow their instructions when using pimecrolimus topical. 11 , 6 , 2 , 22 , 8 , 18 , 16 , 20

Limitations of Current Research

There is still a need for more research on pimecrolimus topical. 11 , 6 , 2 , 22 , 8 , 18 , 16 , 20 Specifically, more research is needed to determine whether pimecrolimus topical increases the risk of lymphoma. 15

Future Research Directions

Further research is needed to assess the long-term safety and efficacy of pimecrolimus topical. 11 , 6 , 2 , 22 , 8 , 18 , 16 , 20 Additional research is also necessary to determine whether pimecrolimus topical increases the risk of lymphoma. 15

Conclusion

Pimecrolimus topical can be effective in treating various skin conditions, including atopic dermatitis, rosacea, seborrheic dermatitis, mycosis fungoides, and oral lichen planus. 11 , 6 , 2 , 22 , 8 , 18 , 16 However, it is important to be aware of the potential side effects, such as skin redness, burning, and itching. 11 , 20 It is also important to consult a doctor and follow their instructions when using pimecrolimus topical. 11 , 6 , 2 , 22 , 8 , 18 , 16 , 20 Further research is needed to better understand the long-term safety and efficacy of pimecrolimus topical. 15

Literature analysis of 22 papers
Positive Content
20
Neutral Content
0
Negative Content
2
Article Type
3
5
8
10
22
1.

Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.

Author: ChuDerek K, ChuAlexandro W L, RaynerDaniel G, GuyattGordon H, Yepes-NuñezJuan José, Gomez-EscobarLuis, Pérez-HerreraLucia C, Díaz MartinezJuan Pablo, Brignardello-PetersenRomina, SadeghiradBehnam, WongMelanie M, CeccacciRenata, ZhaoIrene X, BasmajiJohn, MacDonaldMargaret, ChuXiajing, IslamNazmul, GaoYa, IzcovichAriel, AsiniwasisRachel N, BoguniewiczMark, De BenedettoAnna, CapozzaKorey, ChenLina, EllisonKathy, FrazierWinfred T, GreenhawtMatthew, HuynhJoey, LeBovidgeJennifer, LioPeter A, MartinStephen A, O'BrienMonica, OngPeck Y, SilverbergJonathan I, SpergelJonathan M, Smith BegolkaWendy, WangJulie, WheelerKathryn E, GardnerDonna D, SchneiderLynda

Effective AD treatment

A systematic review of 219 trials found that pimecrolimus, tacrolimus, and moderate-potency topical corticosteroids are among the most effective treatments for atopic dermatitis (AD). Topical antibiotics may be among the least effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Safety and efficacy of Pimecrolimus in atopic dermatitis among Chinese infants: a sub-group analysis of a five-year open-label study.

Author: DouXia, LiuLingling, ZhuXuejun, WenWeijing, NiChunya, ZhaoYi, HeZhixin, LiHongchun, SunQiuning, YangQinping, SunXinfen, GuoYifeng

AD treatment

This study evaluated the safety and efficacy of pimecrolimus in Chinese infants with atopic dermatitis (AD) using data from the PETITE study.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Safety of topical medications in the management of paediatric atopic dermatitis: An updated systematic review.

Author: ZhaoSharon, HwangAustin, MillerCorinne, LioPeter

AD treatment
Topical medication side effects

This systematic review synthesizes the clinical trial literature on the safety and adverse effects of topical medications used to treat atopic dermatitis in children.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

A Comparison of Topical Corticosteroids and Topical Calcineurin Inhibitors for the Treatment of Atopic Dermatitis.

Author: PenaJoseph, ZamezaPriscila Arellano, PixleyJessica N, RemitzAnita, FeldmanSteven R

Treats atopic dermatitis
Skin atrophy
Systemic absorption

This review compares the efficacy and adverse effects of topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI) for treating atopic dermatitis (AD). Tacrolimus (TCI) showed superior efficacy compared to weak TCS, while pimecrolimus (TCI) was less effective. TCI may offer a safer alternative for sensitive skin areas prone to TCS-related side effects.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Cancer risk with topical calcineurin inhibitors, pimecrolimus and tacrolimus, for atopic dermatitis: a systematic review and meta-analysis.

Author: DevasenapathyNiveditha, ChuAlexandro, WongMelanie, SrivastavaArchita, CeccacciRenata, LinClement, MacDonaldMargaret, WenAaron, SteenJeremy, LevineMitchell, PyneLonnie, SchneiderLynda, ChuDerek K,

Atopic dermatitis treatment
Topical calcineurin inhibitor cancer risk

This systematic review examined the risk of cancer in patients with atopic dermatitis exposed to topical calcineurin inhibitors (pimecrolimus or tacrolimus).

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The Efficacy and Safety of Pimecrolimus in Patients With Facial Seborrheic Dermatitis: A Systematic Review of Randomized Controlled Trials.

Author: AlsmeiratOdeh, LakhaniSom, EgaimiMusab, IdrisOsama, ElkhalifaMohamed

Effective SD treatment
Reduced recurrence
Side effects

Pimecrolimus 1% topical cream is effective in treating facial seborrheic dermatitis (SD) and has lower recurrence rates, although it has more side effects than other topical treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Activity and safety of topical pimecrolimus in patients with early stage mycosis fungoides (PimTo-MF): a single-arm, multicentre, phase 2 trial.

Author: Ortiz-RomeroPablo L, Maroñas JiménezLidia, MuniesaCristina, EstrachTeresa, ServitjeOctavio, Fernández-de-MisaRicardo, GallardoFernando, SanmartínOnofre, Riveiro-FalkenbachErica, García-DíazNuria, VegaRosa, LoraDavid, PostigoConcepción, JiménezBlanca, Sánchez-BeatoMargarita, Pedro VaquéJosé, Rodríguez PeraltoJosé Luis, de la CámaraAgustín Gómez, de la CruzJavier, Piris PinillaMiguel Ángel

Response rate
Burning
Pruritus

Topical pimecrolimus 1% cream is active and safe in patients with early stage mycosis fungoides.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

9.

Experts' Consensus on the Use of Pimecrolimus in Atopic Dermatitis in China: A TCS-Sparing Practical Approach.

Author: ZhaoZuotao, GaoXing-Hua, LiWei, WangHua, LiangYunsheng, TangJianping, YaoXu, ZhaoHua, LugerThomas

TCS sparing

This article proposes a TCS-sparing treatment algorithm for the management of atopic dermatitis (AD) in infants, children, adolescents, and adults in China. The algorithm aims to guide clinical practice in China and address the concerns of corticophobia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Phototherapy and topical treatments for cutaneous graft vs. host disease in haematopoietic stem cell transplantation patients: a scoping review.

Author: RostagnoE, CampanatiA, MordiniN, CanniciC, CioceM, De CeccoV, SamaraniE, FoàR, OlivieriA, BottiS

Cutaneous GvHD treatment

This scoping review synthesizes the current knowledge on topical and physical treatments for cutaneous graft-versus-host disease, finding that while various treatments are used, there is no clear gold standard and most interventions seem to have an adjuvant role alongside systemic therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

The efficacy and safety of pimecrolimus 1% cream vs. sertaconazole 2% cream in the treatment of patients with facial seborrhoeic dermatitis: a randomized blinded trial.

Author: AzizzadehMaryam, PahlevanDaryoush, BagheriBahador

FSD treatment
Skin irritation

Pimecrolimus cream was found to be more effective and less irritating than sertaconazole cream in treating facial seborrhoeic dermatitis (FSD) in a double-blind, active-controlled, randomized trial of 60 patients. Pimecrolimus led to a faster response, fewer adverse effects, and a lower relapse rate compared to sertaconazole.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Delgocitinib in atopic dermatitis.

Author: HoJ, MolinS

AD treatment

Delgocitinib ointment, the first topical JAK inhibitor approved for atopic dermatitis (AD), offers a promising treatment option with a favorable safety profile. Further research is needed to explore its long-term efficacy and optimal usage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Pharmacological interventions for periorificial (perioral) dermatitis in children and adults: a systematic review.

Author: GrayN A, TodB, RohwerA, FinchamL, VisserW I, McCaulM

POD treatment
Severity reduction
Abdominal discomfort
Burning
Erythema
Facial dryness
Herpes simplex infection
Pruritus

This review assessed the efficacy and safety of pharmacological interventions for periorificial dermatitis (POD) in children and adults. The evidence for the effects of oral tetracycline, pimecrolimus cream, azelaic acid gel, praziquantel ointment, and topical clindamycin/benzoyl peroxide on POD was low or very low. Well-designed trials are needed to further investigate treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Topical calcineurin inhibitors and risk of lymphoma: a systematic review and meta-analysis.

Author: WuPo-Chien, HuangI-Hsin, LiuChe-Wei, HuangYu-Chen

Corticosteroid sparing
Lymphoma risk
Non-Hodgkin lymphoma risk

This systematic review and meta-analysis investigated the association between topical calcineurin inhibitors (TCIs) and lymphoma risk. The findings indicate that TCI use significantly increases the risk of lymphoma, particularly non-Hodgkin lymphoma. This information is crucial for informing clinical decision-making and considering the potential risks associated with TCI use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Efficacy of topical non-steroidal immunomodulators in the treatment of oral lichen planus: a systematic review and meta-analysis.

Author: da SilvaEduardo Liberato, de LimaTaiane Berguemaier, RadosPantelis Varvaki, VisioliFernanda

OLP treatment

Topical non-steroidal immunomodulators (TNSIs), such as tacrolimus and pimecrolimus, are safe and effective alternatives for oral lichen planus (OLP) treatment. A meta-analysis of 28 studies found that TNSIs showed similar benefits in clinical response and symptom resolution compared to topical steroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Topical calcineurin inhibitors as a double-edged sword in rosacea: A systematic review.

Author: ZhangHanlin, YangLeyan, WangYuchen, ZhangDingyue, TangKeyun, FangRouyu, SunQiuning

Rosacea treatment
Rosacea induction

Topical calcineurin inhibitors, pimecrolimus and tacrolimus, can both treat and induce rosacea. A systematic review of 28 articles showed that these medications were effective in treating rosacea but also had the potential to induce rosacea-like eruptions. Further research is needed to better understand the double-edged sword effects of these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Efficacy and safety of topical administration of tacrolimus in oral lichen planus: An updated systematic review and meta-analysis of randomized controlled trials.

Author: SuZhangci, HuJiaqi, ChengBin, TaoXiaoan

Effective treatment for oral lichen planus
Mild adverse effects

A meta-analysis of 9 randomized controlled trials found that tacrolimus was as effective as corticosteroids in treating symptomatic oral lichen planus but was more likely to cause mild adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Topical epigallocatechin-3-gallate in the treatment of vitiligo.

Author: HuWenting, ZhangLingling, LinFuquan, LeiJiehao, ZhouMiaoni, XuAiE

Vitiligo treatment

Topical application of Epigallocatechin-3-gallate (EGCG) was effective in treating vitiligo with comparable results to pimecrolimus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Topical therapy of atopic dermatitis with a focus on pimecrolimus.

Author: LugerT, PallerA S, IrvineA D, SidburyR, EichenfieldL F, WerfelT, BieberT

Good safety profile
Improved quality of life
Reduced pruritus
Steroid-sparing
Corticophobia/steroid aversion
TCS side effects

Topical calcineurin inhibitors, such as pimecrolimus, are effective in treating atopic dermatitis (AD). They have similar anti-inflammatory effects to topical corticosteroids, reduce pruritus, and improve quality of life. Pimecrolimus is steroid-sparing and has a good safety profile, making it a preferred therapy for children and sensitive skin areas.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and Melanoma: A Systematic Review and Meta-analysis.

Author: LamMegan, ZhuJie Wei, TadrousMina, DruckerAaron M

atopic dermatitis
skin cancer
TCI use
lymphoma risk

This systematic review and meta-analysis found no association between topical calcineurin inhibitor (TCI) use and overall cancer risk. However, there was a significant association between TCI use and an increased risk of lymphoma, but not other skin cancers like melanoma or keratinocyte carcinoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Unmet medical needs in the treatment of atopic dermatitis in infants: An Expert consensus on safety and efficacy of pimecrolimus.

Author: LugerThomas, AugustinMatthias, LambertJulien, PaulCarle, PincelliCarlo, TorreloAntonio, VestergaardChristian, WahnUlrich, WerfelThomas

AD treatment
Skin barrier restoration

This study concluded that pimecrolimus offers a safe and effective alternative to TCS in infants aged 3 months and above, and labeling restrictions in this age group are no longer justified.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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