Tolerance and disposition of cefpimizole in normal human volunteers after intramuscular administration.

Author: LakingsD B, NovakE, PaxtonL M

Paper Details 
Original Abstract of the Article :
Cefpimizole sodium (AC-1370, U-63196E) was administered intramuscularly in doses from 100 mg (0.5 ml) to 2,000 mg (two 3.5-ml doses) to healthy human volunteers in three double-blind placebo and positive-controlled (cefotaxime, cephalothin) single-dose studies and in two multiple-dose studies. Mild ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1128/AAC.31.11.1706

データ提供:米国国立医学図書館(NLM)

Cefpimizole: A Well-Tolerated Cephalosporin with Promising Pharmacokinetic Profile

Cefpimizole is a cephalosporin antibiotic with potential clinical applications. This study investigates the tolerance and pharmacokinetic profile of cefpimizole in healthy human volunteers after intramuscular administration. The authors administered various doses of cefpimizole intramuscularly and monitored the subjects for potential side effects, vital signs, and laboratory parameters. Their findings demonstrate that cefpimizole is well tolerated locally and systemically at all tested dose levels, with a favorable pharmacokinetic profile characterized by sustained serum concentrations and dose-proportional elimination. This information provides valuable insights into the safe and effective use of cefpimizole in clinical settings.

Cefpimizole: A Promising Antibiotic with Favorable Characteristics

The study's findings suggest that cefpimizole holds promise as a safe and effective antibiotic with a desirable pharmacokinetic profile. Its well-tolerated nature and sustained serum concentrations support its potential for treating bacterial infections. This information can guide healthcare providers in making informed decisions about using cefpimizole in their patients, ensuring optimal therapeutic outcomes. Further research is essential to fully explore its clinical potential and establish its place in the antibiotic armamentarium.

Navigating the Desert of Antibiotic Discovery: A New Oasis of Efficacy and Safety

The research highlights the importance of understanding the pharmacokinetic profile and tolerance of new antibiotics. Cefpimizole, with its favorable characteristics, emerges as a promising candidate for treating bacterial infections. This discovery is like finding a refreshing oasis in the vast desert of antibiotic research, offering a potential source of effective and safe treatment for patients battling bacterial infections. This underscores the ongoing quest for new and improved antibiotics to combat the ever-evolving threat of antimicrobial resistance.

Dr. Camel's Conclusion

The study demonstrates the promising potential of cefpimizole as a well-tolerated and effective cephalosporin antibiotic. Its favorable pharmacokinetic profile, characterized by sustained serum concentrations and dose-proportional elimination, supports its potential for treating bacterial infections. Further clinical research is needed to fully explore its therapeutic value and establish its role in the management of bacterial infections.

Date :
  1. Date Completed 1988-03-11
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

3435119

DOI: Digital Object Identifier

10.1128/AAC.31.11.1706

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.