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Tolerance and disposition of cefpimizole in normal human volunteers after intramuscular administration.
Author: LakingsD B, NovakE, PaxtonL M
Original Abstract of the Article :
Cefpimizole sodium (AC-1370, U-63196E) was administered intramuscularly in doses from 100 mg (0.5 ml) to 2,000 mg (two 3.5-ml doses) to healthy human volunteers in three double-blind placebo and positive-controlled (cefotaxime, cephalothin) single-dose studies and in two multiple-dose studies. Mild ...See full text at original site
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引用元:
https://doi.org/10.1128/AAC.31.11.1706
データ提供:米国国立医学図書館(NLM)
Cefpimizole: A Well-Tolerated Cephalosporin with Promising Pharmacokinetic Profile
Cefpimizole is a cephalosporin antibiotic with potential clinical applications. This study investigates the tolerance and pharmacokinetic profile of cefpimizole in healthy human volunteers after intramuscular administration. The authors administered various doses of cefpimizole intramuscularly and monitored the subjects for potential side effects, vital signs, and laboratory parameters. Their findings demonstrate that cefpimizole is well tolerated locally and systemically at all tested dose levels, with a favorable pharmacokinetic profile characterized by sustained serum concentrations and dose-proportional elimination. This information provides valuable insights into the safe and effective use of cefpimizole in clinical settings.
Cefpimizole: A Promising Antibiotic with Favorable Characteristics
The study's findings suggest that cefpimizole holds promise as a safe and effective antibiotic with a desirable pharmacokinetic profile. Its well-tolerated nature and sustained serum concentrations support its potential for treating bacterial infections. This information can guide healthcare providers in making informed decisions about using cefpimizole in their patients, ensuring optimal therapeutic outcomes. Further research is essential to fully explore its clinical potential and establish its place in the antibiotic armamentarium.
Navigating the Desert of Antibiotic Discovery: A New Oasis of Efficacy and Safety
The research highlights the importance of understanding the pharmacokinetic profile and tolerance of new antibiotics. Cefpimizole, with its favorable characteristics, emerges as a promising candidate for treating bacterial infections. This discovery is like finding a refreshing oasis in the vast desert of antibiotic research, offering a potential source of effective and safe treatment for patients battling bacterial infections. This underscores the ongoing quest for new and improved antibiotics to combat the ever-evolving threat of antimicrobial resistance.
Dr. Camel's Conclusion
The study demonstrates the promising potential of cefpimizole as a well-tolerated and effective cephalosporin antibiotic. Its favorable pharmacokinetic profile, characterized by sustained serum concentrations and dose-proportional elimination, supports its potential for treating bacterial infections. Further clinical research is needed to fully explore its therapeutic value and establish its role in the management of bacterial infections.
Date :
- Date Completed 1988-03-11
- Date Revised 2021-05-26
Further Info :
Related Literature
English
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