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Current evidence for the risk of PR prolongation, QRS widening, QT prolongation, from lopinavir, ritonavir, atazanavir, and saquinavir: A systematic review.

Author: BudimanFanny, IvanIgnatius, JuliawatiDwi Jani, RidjabDenio A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Lopinavir, ritonavir, atazanavir, and saquinavir, antiretroviral drugs used for COVID-19 treatment, can cause electrocardiography changes, including PR prolongation, QRS widening, and QT prolongation. Their potential cardiotoxicity should be considered.
Paper Details　
Original Abstract of the Article :
Lopinavir, ritonavir, atazanavir, and saquinavir had been reportedly used or suggested for coronavirus disease 2019 (COVID-19) treatment. They may cause electrocardiography changes. We aim to evaluate risk of PR prolongation, QRS widening, and QT prolongation from lopinavir, ritonavir, atazanavir, a...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341216/

データ提供：米国国立医学図書館（NLM）

Antiretroviral Drugs and Electrocardiography: A Desert of Potential Risks

My fellow researchers, imagine a desert expedition where explorers must navigate treacherous terrain and potential dangers. This study delves into the potential risks associated with certain antiretroviral drugs, specifically lopinavir, ritonavir, atazanavir, and saquinavir, on electrocardiography (ECG) parameters. The researchers conducted a systematic review to assess the risk of PR prolongation, QRS widening, and QT prolongation associated with these drugs.

The study found that these antiretroviral drugs could potentially affect ECG parameters. The authors emphasize the importance of monitoring ECG changes in patients taking these drugs, especially those with pre-existing heart conditions. The research serves as a reminder of the importance of carefully considering potential drug interactions and their impact on heart health.

Navigating Drug Interactions

This study highlights the importance of understanding potential drug interactions. It's like navigating a desert landscape where unexpected obstacles can arise. The study underscores the need for careful monitoring of ECG parameters in patients taking these antiretroviral drugs to mitigate potential risks.

The Importance of Cardiovascular Monitoring

The research emphasizes the importance of cardiovascular monitoring in patients taking antiretroviral drugs. It's like ensuring a safe journey through a desert, monitoring the health of the camel caravan. The study encourages healthcare professionals to be vigilant in monitoring ECG changes in patients taking these drugs, especially those with pre-existing heart conditions.

Dr.Camel's Conclusion

This study explores the potential risks associated with certain antiretroviral drugs on ECG parameters. It's a reminder that even seemingly safe medications can have unexpected effects. The study highlights the importance of careful monitoring of ECG changes in patients taking these drugs, ensuring their cardiovascular health throughout the treatment process.

Date :
  1. Date Completed 2021-08-24
  2. Date Revised 2023-01-03
Further Info :

Pubmed ID

34397829

DOI: Digital Object Identifier

PMC8341216

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Languages

English

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